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Study on trinpanchmool kwath for essential hypertension treatment.

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Journal name: Ayushdhara
Original article title: A clinical study to evaluate the antihypertensive effect of trinpanchmool kwath in management of essential hypertension
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Original source:

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Author(s):

Prerna
Research Scholar, P.G. Dept of Kayachitiksa, RGGPG Ayurvedic College, Paprola, Himachal Pradesh, India.
Vijay Chaudhary
Professor and H.O.D, P.G. Dept of Kayachitiksa, RGGPG Ayurvedic College, Paprola, Himachal Pradesh, India.
B.L. Mehra
Professor and Former H.O.D., P.G. Dept of Kayachitiksa, RGGPG Ayurvedic College, Paprola, Himachal Pradesh, India.


Ayushdhara:

(A peer-reviewed, bi-monthly open-access journal)

Full text available for: A clinical study to evaluate the antihypertensive effect of trinpanchmool kwath in management of essential hypertension

Year: 2020 | Doi: 10.47070/ayushdhara.v7iSupply1.598

Copyright (license): CC BY-NC-SA 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study investigates the antihypertensive effects of Trinpanchmool Kwath, an Ayurvedic formulation, on essential hypertension. Conducted at R.G.G. P.G.A.C. and Hospital in Himachal Pradesh, India, thirty patients with newly diagnosed stage-I hypertension were selected for the trial. They were divided into three groups to receive varying treatments: Trinpanchmool Kwath alone, the conventional antihypertensive drug Chlorthalidone, and a combination of both. The study aimed to evaluate the efficacy and safety of Trinpanchmool Kwath in managing essential hypertension.

Efficacy of Trinpanchmool Kwath

The results demonstrated significant reductions in both systolic and diastolic blood pressure across all groups after 45 days of treatment. In Group I, patients receiving Trinpanchmool Kwath alone experienced a 9.37% reduction in systolic blood pressure, whereas Group II, treated with Chlorthalidone, showed a 15.46% decrease. Remarkably, Group III, which combined both treatments, observed the greatest reduction in systolic blood pressure at 16.86%. The comparative analysis highlighted that while all three groups showed significant improvements, the combination therapy yielded the most pronounced results, reinforcing the potential effectiveness of Trinpanchmool Kwath in hypertension management.

Safety and Acceptability

In terms of safety, the study reported no adverse effects from the Trinpanchmool Kwath during the trial period, signifying its good tolerability among patients. Additionally, subjective parameters, including headache, giddiness, palpitation, and breathlessness, showed improvement across all groups. The statistical significance of these improvements suggests that Trinpanchmool Kwath not only effectively lowers blood pressure but also lessens associated symptoms, thereby enhancing patient quality of life. This supports the traditional use of Ayurvedic formulations alongside conventional treatments in managing essential hypertension safely.

Conclusion

The clinical evaluation affirmed the effectiveness and safety of Trinpanchmool Kwath in the management of essential hypertension. Particularly, the combination of Trinpanchmool Kwath with Chlorthalidone was found to deliver superior results compared to either treatment alone. Given the ongoing challenges with conventional antihypertensive medications, which often come with adverse effects, Trinpanchmool Kwath presents a promising alternative. This study advocates for further research on Ayurvedic treatments and their integration into standard hypertension care protocols.

FAQ section (important questions/answers):

What was the primary aim of the study on Trinpanchmool Kwath?

The primary aim was to evaluate the efficacy of Trinpanchmool Kwath in managing essential hypertension, focusing on its antihypertensive effects compared to the standard medication, Chlorthalidone.

How were patients grouped in the antihypertensive study?

Thirty patients were randomly divided into three groups: Group-I received Trinpanchmool Kwath, Group-II was treated with Chlorthalidone, and Group-III received both treatments to assess their respective effects on blood pressure.

What were the findings regarding blood pressure reduction in the study?

The study found significant reductions in both systolic and diastolic blood pressure across all groups. Group-III, combining Trinpanchmool Kwath with Chlorthalidone, showed the most effective results.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study on trinpanchmool kwath for essential hypertension treatment.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Blood:
Blood is crucial for monitoring hypertension, as changes in systolic and diastolic blood pressure were key criteria in evaluating the antihypertensive effect of Trinpanchmool Kwath. Blood pressure readings were central to the study's objectives and assessments.

2) Pulse:
Pulse rate was measured as an objective criterion in this study to evaluate the effects of Trinpanchmool Kwath on patients with essential hypertension. It helps assess cardiovascular efficiency and detect irregularities in heart functioning.

3) Bhrama:
Bhrama, or giddiness, is one of the subjective criteria used to evaluate the effect of the therapy. The reduction in Bhrama scores indicated improvements in patient symptoms due to the antihypertensive treatment.

4) Drug:
The study involved two main drugs: Trinpanchmool Kwath, an Ayurvedic formulation, and Tab. Chlorthalidone, a conventional antihypertensive drug. Both were evaluated for their efficacy in reducing blood pressure among patients with essential hypertension.

5) India:
India is mentioned as a country with high incidences of lifestyle diseases such as hypertension. The study was conducted in Rajiv Gandhi Govt. Post Graduate Ayurvedic College & Hospital Paprola, Himachal Pradesh, India.

6) Disease:
Hypertension is the specific disease studied here, referred to as a significant health issue that increases risks for various cardiovascular and renal diseases. The study aims to find effective treatment options for this widespread condition.

7) Shakti (Sakti):
Shakti refers to strength or power, and in this context, it denotes physical capabilities like Vyayama Shakti (exercise capability) and the strength of the body functions (Madhyama Vyayama Shakti). It helps gauge the physical well-being of patients in the study.

8) Vata:
Vata is one of the three doshas in Ayurveda associated with movement and physiological functionalities. The study acknowledges that hypertension is predominantly a Vata disorder, which the Trinpanchmool Kwath aims to balance.

9) Diet:
Diet plays a crucial role in managing hypertension, with the study indicating vegetarians generally have lower blood pressure than non-vegetarians. Dietary habits were part of the patient assessments in the study.

10) Madhura:
Madhura refers to a sweet taste in Ayurvedic terminology, and in this study, it is noted that Trinpanchmool Kwath has Madhura Rasa, making it effective in balancing the doshas and helping manage hypertension.

11) Rasa (Rasha):
Rasa refers to taste, one of the properties used to describe Ayurvedic medicines. The Trinpanchmool Kwath has Madhura (sweet) and Kashaya (astringent) Rasa, which contribute to its therapeutic effects.

12) Vyayamashakti (Vyayamasakti, Vyayama-shakti):
Vyayama-shakti denotes the physical capacity for exercise. It was assessed in patients to understand their baseline physical fitness and its improvement through the treatment of hypertension in the study.

13) Madhurarasa (Madhura-rasa):
Madhura-rasa is the sweet taste attribute in Ayurvedic medicine, which helps in balancing Vata and Pitta doshas. This property of Trinpanchmool Kwath contributed to its antihypertensive effects in the clinical study.

14) Tridosha (Tridosa, Tri-dosha):
Tridosha refers to the three fundamental bodily humors in Ayurveda: Vata, Pitta, and Kapha. Hypertension is considered a Tridosha Vyadhi, predominantly involving Vata, which Trinpanchmool Kwath aims to balance.

15) Madhyama:
Madhyama refers to a moderate level. In the study, it is used in various contexts, such as Madhyama Vyayama Shakti (moderate exercise capacity) and Madhyama Aahara Shakti (moderate digestive power).

16) Prakriti (Prakrti):
Prakriti refers to the natural constitution or body type in Ayurveda. This study considered patients' Prakriti, such as Vata-Pittaj Deha Prakriti, to tailor the treatment and assess its effects accurately.

17) Vyayama:
Vyayama stands for exercise, significant in managing hypertension. The study notes the importance of Vyayama in increasing blood circulation and reducing blood lipids, contributing to the overall treatment efficacy.

18) Samaka (Shamaka):
Shamaka refers to pacifying or balancing. The Trinpanchmool Kwath in the study is described to have Tridosha Shamaka properties, helping to balance Vata, Pitta, and Kapha, which are crucial in managing hypertension.

19) Vipaka:
Vipaka refers to the post-digestive effect of food and drugs in Ayurveda. The study mentions the Madhura Vipaka (sweet post-digestive effect) of Trinpanchmool Kwath, which aids in balancing doshas and managing hypertension.

20) Pitta:
Pitta is one of the three doshas in Ayurveda governing metabolic processes. The study evaluates how Trinpanchmool Kwath, having a Pitta-Shamaka effect, helps in reducing hypertension through dosha balance.

21) Discussion:
The Discussion section of the study interprets the collected data, analyzing the antihypertensive effects of Trinpanchmool Kwath compared to conventional treatments, and discusses lifestyle factors influencing hypertension.

22) Samhanana:
Samhanana refers to the body’s build or compactness. The study assessed Samhanana to understand the physical constitution of the patients, which influences how they respond to treatments for hypertension.

23) Education:
[see source text or glossary: Education]

24) Pramana:
Pramana means measure or dimension. This term indicates the assessment of physical and physiological attributes in patients, considered while diagnosing and evaluating the effectiveness of the treatment for hypertension.

25) Snigdha:
Snigdha means oily or unctuous. This quality of the Trinpanchmool Kwath helps pacify Vata, one of the doshas responsible for hypertension, thus aiding in the treatment process.

26) Kashaya (Kasaya):
Kashaya refers to an astringent taste in Ayurvedic medicine, one of the therapeutic tastes of Trinpanchmool Kwath. It helps balance the Kapha dosha and contributes to the formulation’s antihypertensive properties.

27) Madura:
[see source text or glossary: Madura]

28) Kangra:
Kangra is a district in Himachal Pradesh, India, where the study was conducted at Rajiv Gandhi Govt. Post Graduate Ayurvedic College & Hospital Paprola, providing a geographical and institutional context for the research.

29) Vyadhin (Vyadhi):
Vyadhi translates to disease. The study focuses on managing hypertension, a complex Vyadhi influenced by multiple factors like lifestyle, diet, and stress, which the Ayurvedic formulation aimed to address.

30) Family:
Family here refers to the botanical family of the plants used in Trinpanchmool Kwath. For instance, Poaceae is the family to which various Trinpanchmool ingredients belong, significant for standardizing the herbal formulation.

31) Cancer:
[see source text or glossary: Cancer]

32) Manas (Mano, Manash):
Manas refers to the mind or mental constitution in Ayurveda. The study patients had Rajsik Manas Prakriti, indicating their mental disposition, which influences how they experience and manage stress contributing to hypertension.

33) Kapha:
Kapha is one of the three doshas in Ayurveda linked to body structure and fluid balance. The study’s formulation, Trinpanchmool Kwath, targets balancing Kapha to help manage hypertension effectively.

34) Satva (Shatva):
Satva is a term that denotes mental strength or the quality of the mind. The patients' satva level, which was predominantly Madhyama, indicates their mental resilience affecting how they manage hypertension.

35) Ikshu (Iksu):
Ikshu, or Saccharum officinarum, is one of the ingredients of Trinpanchmool Kwath. Its root is used in the Ayurvedic formulation to manage hypertension, contributing to the remedy's therapeutic properties.

36) Mamsa (Mamsha):
Mamsa refers to muscle tissue in Ayurveda. In this study, many patients had Mamsa Sara (predominance of muscle tissue) that helped assess their physical health status alongside hypertension management.

37) Avara:
Avara refers to less. In this document, it is used to describe Avara Vyayama Shakti (less exercise capacity), which affects how effectively the body can manage conditions like hypertension.

38) Munja (Mumja):
Munja, or Saccharum Munja, is an ingredient in Trinpanchmool Kwath. Its root is included for its health benefits, contributing to the formulation's efficacy in managing essential hypertension.

39) Sara (Shara):
Sara refers to the essence or superior quality of tissues. In the context of Hematological assessments in the study, it helps in understanding how well-nourished and resilient the tissues are.

40) Ayus (Ayush):
[see source text or glossary: Ayush]

41) Death:
Death here refers to the severe outcomes of unmanaged hypertension, as it is linked to a higher risk of cardiovascular diseases leading to mortality. Managing hypertension is crucial to preventing such outcomes.

42) House:
House or household activities are referred to in assessing patients' daily routines, particularly those involved in housework. These activities could impact the physical exertion levels relevant to managing hypertension.

43) Cina:
China is mentioned as an example alongside India, representing regions with a high number of hypertension cases, a global health issue addressed in the study.

44) Deha:
Deha refers to the body, and Deha Prakriti denotes the physical constitution (body type) in Ayurveda. The study uses concepts like Vata-Pittaj Deha Prakriti for a comprehensive patient assessment.

45) Guna:
Guna means quality or attribute. In the study, various Gunas (like Snigdha, Sheeta) of Trinpanchmool Kwath are noted for their roles in balancing doshas and improving the treatment of hypertension.

46) Mana:
[see source text or glossary: Mana]

47) Salt (Salty):
Salt intake is a known factor contributing to hypertension mentioned in the document. Managing diet, including reducing salt intake, is a crucial aspect of controlling blood pressure levels.

Other Science Concepts:

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Discover the significance of concepts within the article: �Study on trinpanchmool kwath for essential hypertension treatment.�. Further sources in the context of Science might help you critically compare this page with similair documents:

Who, Clinical trial, Statistically significant reduction, Antihypertensive effect, Systolic blood pressure, Diastolic blood pressure, Sphygmomanometer, Combination therapy, Subjective Criteria, Objective Criteria, Statistical assessment, Essential hypertension, Randomized control group, Randomly divided, Hematological Profile, Biochemical profile, Madhyama Vyayama Shakti, Aetiological factor.

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