Protein fiber in drug delivery system
Journal name: World Journal of Pharmaceutical Research
Original article title: Protein fiber in drug delivery system
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Vaishnavi Mohanrao Sonawane, Pranali Hatwar and Dr. Gajanan Sanap
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Protein fiber in drug delivery system
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202322-30680
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
With the emergence of novel drug therapies, the demand for advanced drug delivery systems has significantly increased. Traditional methods often fall short due to the inherent instability and rapid clearance of biomolecular drugs such as proteins and oligonucleotides. These drugs frequently degrade in circulation or are lost via enzymatic action in the gastrointestinal tract, necessitating the need for controlled, non-toxic, and long-term delivery systems. The recent interest in protein-based polymers as drug delivery carriers arises from their biocompatibility, biodegradability, and ability to reform into various structures like films, gels, and nanoparticles. This review elucidates the potential of these natural protein biopolymers, focusing on sources, structural properties, applications, and their capability to enhance targeted drug delivery.
Protein-Based Polymers in Drug Delivery
Protein-based polymers present several advantages over synthetic alternatives in drug delivery applications. They exhibit excellent biocompatibility and biodegradability, making them more suitable for medical use. Notable proteins such as keratin, collagen, elastin, and silk have distinct structural and functional attributes that enable their application in various biomedical fields. For example, collagen's structural integrity supports tissue engineering and drug delivery, while elastin's elastic properties offer potential for controlled drug release through responsive mechanisms. These proteins can be developed into targeted drug delivery systems that not only improve drug stability but also enhance the controlled release rates, which are critical for effective treatment strategies.
Importance of Silk in Biomedical Applications
Silk proteins, primarily derived from silkworms and spiders, stand out in the drug delivery systems due to their unique structural characteristics and processing advantages. They can be engineered into various forms like films, hydrogels, and nanoparticles, allowing for controlled and sustained release of drugs. The mild processing conditions used in silk-based materials minimize the risk of denaturing sensitive drugs. Additionally, the adjustable solubility of silk can be tailored to regulate the release of therapeutic agents, exemplifying its role as an ideal candidate for long-term drug delivery applications. The continuous development of silk-based materials fosters new avenues for acute and chronic treatment regimens.
Keratin and Collagen as Drug Carriers
Keratin and collagen are animal-derived proteins frequently researched for their applications in drug delivery and tissue repair. Keratin, which can be sourced from animal by-products such as feathers and hair, is both cost-effective and versatile. Its biocompatibility and tunable properties make it ideal for various biomedical applications, including wound healing and drug delivery systems. Similarly, collagen, which is a primary component of connective tissues, is extensively used in therapy due to its excellent mechanical properties and biocompatibility. However, challenges such as degradation through enzymatic activity can be mitigated through chemical crosslinking techniques, enhancing its stability for drug delivery applications.
Conclusion
The prospective applications of protein-based polymers in drug delivery are immense, driven by their inherent advantages in biocompatibility and biodegradability. Natural proteins like silk, collagen, elastin, and keratin each bring unique properties that enable their use in varied therapeutic contexts. The capacity to fabricate these proteins into multiple forms and tailor their properties is paving the way for innovative controlled release systems. As research progresses, the refinement of these protein materials and the development of methods to overcome their limitations may unlock new therapeutic applications, offering hope for improved treatment outcomes across a range of medical conditions.
FAQ section (important questions/answers):
What is the significance of protein-based polymers in drug delivery?
Protein-based polymers offer excellent biocompatibility, biodegradability, and sustainability, making them superior to synthetic polymers for targeted and controlled drug delivery systems.
How do protein materials enhance the effectiveness of drug delivery systems?
Protein materials, such as collagen and keratin, can protect drugs from degradation and control their release rates, improving overall therapeutic effectiveness and patient compliance.
What roles do animal and plant proteins play in drug delivery?
Both animal proteins like collagen and plant proteins like zein provide unique advantages, including better drug encapsulation, controlled release characteristics, and reduced risk of side effects.
What are advanced applications of protein materials in medicine?
Protein materials are used in bone healing, antibiotic release, cancer treatment, and wound healing due to their ability to deliver drugs effectively to specific sites.
Why is targeted drug delivery important for chronic conditions?
Targeted drug delivery allows for the administration of therapeutic agents directly to the affected area, reducing systemic side effects and increasing treatment efficacy.
What types of formulations can be created from protein materials?
Protein materials can be processed into various formulations such as films, nanoparticles, hydrogels, and microparticles, which are useful for different drug delivery applications.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淧rotein fiber in drug delivery system鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Medicine:
Medicines encompass a broad range of substances that aid in treatment, prevention, or diagnosis of health disorders. The therapeutic effectiveness of medicines is often challenged by issues like bioavailability and stability, which have led to the exploration of innovative delivery systems to improve patient outcomes.
2) Silk:
Silk is a natural protein fiber produced by silkworms and certain spiders. It has gained attention in biomedical applications for its favorable properties, including biocompatibility and biodegradability. Silk can be engineered into various forms for drug delivery systems, promoting controlled and sustained release of therapeutic agents.
3) Drug:
Drugs are substances that cause physiological changes for therapeutic purposes. The advancement of drug delivery technologies is crucial for enhancing the efficacy and safety of drugs, providing targeted therapies that minimize side effects while maximizing therapeutic benefits.
4) Cancer:
Cancer is a disease characterized by uncontrolled cell division, leading to the formation of tumors. Treatment strategies often require targeted drug delivery systems to minimize side effects and enhance therapeutic efficacy, directing medicines specifically to cancerous tissues while sparing healthy cells.
5) Beast:
The term 'beast' generally refers to animals, and in a biomedical context, animal-derived proteins are often explored for their potential in drug delivery systems. Proteins from animal sources can exhibit high biocompatibility, enhancing the effectiveness of drug delivery while offering sustainable options.
6) Hair:
Hairs, as sources of keratin, can be processed for biomedical applications. Keratin derived from animal hair is biodegradable, biocompatible, and can be utilized in drug delivery systems, offering sustainable and effective solutions for therapeutic interventions.
7) Substance:
Substances refer to compounds or materials that undergo changes in interactions, particularly in drug formulations. Understanding how different substances interact is critical for developing effective drug delivery systems, ensuring stability, targeted delivery, and release kinetics in therapeutic applications.
8) Nature:
Nature refers to the natural world and the inherent characteristics of organisms, including proteins. In drug delivery research, harnessing natural materials such as proteins and polysaccharides for biomedical applications is gaining momentum, focusing on sustainability and biocompatibility to improve patient care.
9) Blood:
Blood serves as a vital bodily fluid transporting nutrients, gases, and waste products. In drug delivery systems, understanding blood circulation is essential for developing effective therapies, particularly for targeted drug delivery that minimizes impact on non-target tissues and enhances drug bioavailability.
10) Antibiotic (Antibacterial):
Antibacterial refers to substances that inhibit bacterial growth. Incorporating antibacterial properties in drug delivery systems can enhance healing and effectiveness, particularly in treating infections, making this a crucial area in the design of therapeutic interventions.
11) Surface:
Surfaces are key in determining interactions at the interface of drug delivery systems and biological environments. Engineering surfaces of delivery vehicles can significantly impact how drugs are released and absorbed, enhancing treatment efficacy and safety.
12) Animal:
In the context of drug delivery, 'animal' refers to protein sources derived from animals, which can be integral for developing biocompatible carriers. These proteins, such as collagen and gelatin, offer favorable structural and functional properties for various medical applications.
13) Study (Studying):
Studying refers to the systematic exploration of topics, essential in research. In drug delivery, studying various materials, interactions, and effects helps advance knowledge, leading to the development of more effective therapeutic strategies and formulations.
14) Biodegradable:
Biodegradable materials are those that can break down naturally in the environment through biological processes. In drug delivery, biodegradable polymers are essential for developing systems that reduce environmental impact while safely delivering therapeutic agents, promoting sustainability in pharmaceutical applications.
15) Composite:
Composites are materials composed of two or more distinct components, providing improved properties over individual materials. In drug delivery, composites often enhance stability, biocompatibility, and performance of drug formulations, facilitating more effective therapeutic strategies for diverse medical applications.
16) Science (Scientific):
Sciences encompass diverse fields of study that contribute to our understanding of the natural world. In pharmaceuticals, various sciences integrate to focus on drug development, delivery, and efficacy, pushing the boundaries of medical research and application.
17) Water:
Water is a universal solvent and plays a critical role in biological systems and drug formulation. The solubility of many drugs is influenced by their interactions with water, impacting their bioavailability and the design of delivery systems that facilitate effective administration.
18) Rich (Rch):
Rich, in this context, refers to a significant abundance or concentration of substances, often highlighting the nutritional or bioactive content. In drug formulation, rich protein sources can improve the effectiveness and delivery of therapeutic agents, particularly in natural protein-based carriers.
19) Gold (Golden):
Gold nanoparticles are utilized in various biomedical applications, including drug delivery, due to their unique optical and electronic properties. Their stability and ease of modification make them promising candidates for targeted therapies and imaging applications in medical sciences.
20) Performance:
Performance in drug delivery systems relates to the efficacy and consistency of releasing therapeutic agents. Variables such as material properties, environmental factors, and drug characteristics significantly influence the performance of drug delivery formulations, determining their therapeutic success.
21) Commerce:
Commerce in pharmaceuticals involves the trade of drugs and related products. Effective drug delivery systems can drive market demand, affecting the economic viability of pharmaceutical companies and influencing their investments in research and development of innovative therapies.
22) Dressing:
Dressing refers to the materials applied to wounds. In biomedical applications, protein-based dressings can be developed for drug delivery, providing controlled-release mechanisms that promote healing while offering antimicrobial protection, crucial for treating infections and supporting tissue regeneration.
23) Account:
Accounts refer to detailed descriptions or narratives documenting scientific research, methodologies, and outcomes. Accurate accounts are vital in disseminating knowledge in the fields of drug delivery and biomedical research, enabling assessments and advancements in therapeutic strategies.
24) Food:
Food is any substance consumed to sustain life, providing essential nutrients. Plant-derived proteins are utilized in drug delivery systems, aligning with food science to explore how edible substances can contribute to health, wellness, and therapeutic interventions.
25) Inflammation:
Inflammation is the body's response to injury or infection, often requiring targeted drug delivery for effective treatment. Developing delivery systems that focus on inflamed tissues can optimize therapeutic outcomes and reduce systemic side effects in various medical conditions.
26) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India known for its contributions to education and healthcare. Research institutions in Maharashtra may drive advancements in pharmaceutical sciences, focusing on innovative drug delivery systems utilizing local resources and expertise in biopolymers and medicinal chemistry.
27) Vaishnavi (Vaisnavi):
Vaishnavi Mohanrao Sonawane is a researcher associated with studies on protein-based drug delivery systems. Her contributions help advance understanding in the fields of pharmaceutical sciences and biomaterials, focusing on the development of effective therapies for various health challenges.
28) Disease:
Disease refers to any deviation from normal physiological functioning, often requiring medical interventions. The effective delivery of drugs is critical for managing diseases, necessitating innovations in drug delivery systems to ensure accurate dosing and targeted therapeutic effects.
29) Wisdom:
Wisdom in the context of scientific research refers to the accumulated knowledge and understanding gained through study and experimentation. Applying wisdom to the development of drug delivery systems enables researchers to create innovative therapies that effectively address medical challenges.
30) Repair:
Repair pertains to the biological processes that restore damaged tissues or organs. In drug delivery, systems engineered using biodegradable materials can enhance repair mechanisms, providing localized treatment essential for promoting healing and regeneration following injury or surgery.
31) Spider:
Spider silk, produced by spiders, is known for its exceptional strength and biocompatibility. The unique properties of spider silk have led to its exploration in drug delivery applications, offering potential for developing sustainable and effective therapeutic systems in biomedicine.
32) Visit:
Visit refers to the act of going to see or consult professionals, often in healthcare settings. Patient visits are essential for evaluating treatment effectiveness, reinforcing the importance of developing reliable drug delivery systems for improved therapeutic experiences.
33) India:
India is a country with a rich history of medicinal practices and advancements in pharmaceuticals. The ongoing research and development in drug delivery systems within India is critical for improving healthcare access and outcomes, particularly with the utilization of local resources like plant proteins.
34) Table:
A table is a systematic arrangement of data. In the context of scientific research, tables often summarize findings and comparisons between different formulations or materials used in drug delivery systems, facilitating clearer communication of complex information.
35) Field:
Fields encompass various areas of study or expertise. In pharmaceutical research, fields such as biotechnology, medicinal chemistry, and materials science play crucial roles in the development of innovative drug delivery systems and therapeutic strategies.
36) Wall:
Wall refers to barriers present in biological systems, such as cellular membranes. A comprehensive understanding of these walls is critical for designing effective drug delivery systems that target specific tissues and enhance therapeutic efficacy.
37) Beta:
Beta refers to a type of protein structure, such as beta-keratin, which influences various properties in drug delivery applications. Understanding beta structures is integral in engineering proteins that fulfill specific functional requirements when designed for biomedical uses.
38) Meat:
Meat refers to animal flesh consumed in diets and serves as a source of protein. Animal proteins derived from meat can be utilized in drug delivery systems, offering not only nutritional value but potential therapeutic applications in medicine.
39) Milk:
Milk, as a source of casein, provides high-quality proteins essential for various nutritional and therapeutic applications. Casein-based drug delivery systems can exploit the unique properties of milk proteins to enhance drug stability and release profiles in biomedical applications.
40) Chemotherapy:
Chemotherapy is a treatment technique using drugs to kill or slow the growth of cancer cells. Developing effective drug delivery systems specifically for chemotherapy drugs is essential for targeting tumors while minimizing systemic side effects, improving overall treatment outcomes.
41) Surrounding:
Surrounding denotes the environment around specific biological tissues or areas where drug delivery occurs. Understanding the surrounding conditions is paramount in engineering systems that effectively target and release therapeutic agents where needed.
42) Arrangement:
Arrangement in drug delivery systems refers to how substances are organized to optimize effectiveness. The strategic arrangement of drugs or biomaterials influences release kinetics, stability, and interactions with the biological environment, critical to successful therapy.
43) Similarity:
Similarity pertains to the common characteristics shared between materials or biological entities. In drug delivery, assessing the similarity between different polymers can guide researchers in selecting appropriate materials for developing effective and biocompatible drug carriers.
44) Evolution:
Evolution, in a scientific sense, refers to the gradual development and adaptation of organisms or materials over time. In pharmaceuticals, the evolution of materials science contributes to innovative drug delivery systems, enhancing treatment efficacy and safety.
45) Blindness:
Blindness is a visual impairment that may result from various medical conditions. Targeted drug delivery systems focusing on ocular regions aim to combat blindness effectively, developing therapies to address underlying issues, thereby improving visual health.
46) Stiffness:
Stiffness refers to the rigidity of materials, which can play a significant role in tissue engineering and drug delivery. Understanding the stiffness of biomaterials can help tailor them for specific applications by optimizing interactions with biological tissues.
47) Affection:
Affection in a medical context can refer to diseases or conditions impacting health. Understanding different affections drives the need for innovative drug delivery systems that effectively target therapies to those conditions, improving patient outcomes.
48) Pranali:
Pranali Hatwar is a co-author in the discussed research on protein-based drug delivery systems. Her contributions reflect the collaborative efforts in advancing pharmaceutical sciences and enhancing the understanding of biodegradable materials for effective therapeutic applications.
49) Quality:
Quality signifies the standard of materials and formulations used in drug delivery. Maintaining high quality in drug preparations is essential for ensuring their efficacy, safety, and overall therapeutic effectiveness in various medical applications.
50) Gelatin:
Gelatin is a gelling agent derived from collagen, widely used in pharmaceuticals and food. In drug delivery, gelatin can provide a biocompatible and biodegradable matrix for sustaining drug release, assisting in targeted therapy and improving patient adherence.
51) Balaji:
Balaji Srinivasan is a researcher noted for contributions to biomaterials in drug delivery systems. His work enhances understanding of how natural and biodegradable materials can improve therapies for various health conditions, promoting advancements in the field.
52) Huayan:
Huayan Yang is cited in the context of protein corona studies. Research involving Huayan contributes to understanding how proteins interact with nanoparticles, which is vital for optimizing drug delivery systems and enhancing therapeutic performance.
53) Karin (Kari):
Karin Nienhaus is recognized for her work on protein interactions with nanoparticles. Research attributed to Karin helps elucidate factors influencing the protein corona's impact on drug delivery efficiency, promoting advancements in medical applications and nano-research.
54) Rishi (Rsi, Risi):
Rishi Paliwal is noted for his research into zein proteins for drug delivery applications. His contributions aid in understanding how plant-based proteins can be utilized to develop novel systems for controlled substance release.
55) Death:
Death refers to the permanent cessation of biological functions that sustain life. Understanding diseases leading to death emphasizes the need for effective treatments and therapies, driving research in drug delivery systems that can combat terminal illnesses like cancer.
56) Birth:
Birth refers to the beginning of life or the initiation of processes. In a medical context, ensuring that effective drug delivery systems are available from birth can play a vital role in addressing healthcare challenges and enhancing survival rates in neonatal care.
57) Fight:
Fight pertains to efforts to overcome health challenges and diseases. In biomedical research, the fight against diseases drives the innovation of targeted drug delivery systems, enhancing the effectiveness of treatments and improving patient quality of life.
58) Cina:
China has made significant advancements in pharmaceuticals and biotechnology. Research initiatives and industrial developments in China contribute to the global understanding of drug delivery systems, driving innovations in therapies and materials for health improvement.
59) Jacob:
Jacob Zhang is cited in connection with research in the field of drug delivery involving nanoparticles. His contributions help understand nanoparticle behavior in biological systems, enhancing the design of effective drug delivery formulations.
60) Zhili:
Zhili Peng is recognized for his research contributions in pharmacological applications. His studies provide insights into the characterization of drug delivery systems, particularly focusing on protein interactions and efficacy in therapeutic interventions.
61) Shang:
Shang Li is a researcher associated with the study of protein interactions with nanoparticles. Insights gained from Shang's research highlight the importance of the protein corona in optimizing the performance of drug delivery systems in clinical applications.
62) Naga (Nag):
Naga is often associated with biocompatible systems in research. Understanding materials named after this term can inform the design of drug delivery systems that effectively target therapeutic agents for enhanced treatment outcomes.
63) Musha (Musa, Mus谩):
Musa Ozboyaci's research focuses on studying protein interactions in drug delivery systems. His work is valuable in determining how proteins influence the behavior of drug particles, optimizing therapeutic applications for better patient care.
64) Peng:
Zhili Peng is noteworthy for contributions to the study of protein-based drug delivery systems. His research aids in advancing the characterization and performance of novel therapeutic formulations aimed at improving patient outcomes.
65) Fish:
Fish proteins are being explored as sustainable resources for drug delivery applications. Extracting proteins from fish can provide biodegradable and biocompatible materials, enhancing the development of effective therapies for various medical conditions.
66) Hand:
Hand in this context may represent manual skills or interventions in medical procedures. Understanding the physical dynamics of hand interactions with patients is important for implementing effective therapies and enhancing human factors in drug delivery systems.
67) Post:
Post often refers to follow-up work or communication within medical and research contexts. Following up on findings from studies is crucial for refining drug delivery systems and ensuring they are safely and effectively integrated into clinical practice.
68) Rat:
Rats are frequently used in biomedical research as model organisms for studying drug effects and testing delivery systems. Their physiological similarities to humans make them relevant for understanding drug pharmacokinetics and pharmacodynamics in therapeutic applications.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Protein fiber in drug delivery system鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Biocompatibility, Controlled release, Bone healing, Cancer treatment, Drug delivery, Hydrogel, Biomedical application, Animal protein.