Efficacy of Madhyama Panchamoola Churna in Oligospermia: Case Report
Journal name: Ayushdhara
Original article title: Efficacy of madhyama panchamoola churna in ksheenashukra (oligospermia) - a case report
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Nagendra Chary.M
Ph.D Scholar, Department of Dravyaguna, Government Ayurveda Medical College, Bengaluru, Karnataka.
Lalitha B.R
Professor and HOD, Department of Dravyaguna, Government Ayurveda Medical College, Bengaluru, Karnataka.
T.Anil Kumar
Professor and HOD, Department of Medicine, M.S Ramaiah Medical College, Bengaluru, Karnataka.
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: Efficacy of madhyama panchamoola churna in ksheenashukra (oligospermia) - a case report
Year: 2021 | Doi: 10.47070/ayushdhara.v8i2.722
Copyright (license): CC BY-NC-SA 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Male infertility is a condition characterized by the inability of a male to conceive with a fertile partner, responsible for 40-50% of infertility cases globally. The classical Ayurvedic texts describe male fertility issues under eight types of "Shukradusti," with "Ksheenashukra" signifying a reduced sperm concentration, which aligns with the modern medical understanding of Oligospermia. This study investigates the efficacy of "Madhyamapanchamoola Churna," a combination of Ayurvedic herbs, in improving seminal parameters in a case of Oligospermia.
Madhyamapanchamoola Churna: A Promising Solution
"Madhyamapanchamoola," composed of herbs such as Bala, Punarnava, Eranda, Mudgaparni, and Mashaparni, possesses properties that enhance reproductive health. The study documented a 32-year-old male with a history of infertility, presenting with low sperm count and motility. After a treatment regimen of "Madhyamapanchamoola Churna" for three months, significant improvements were recorded: sperm concentration increased from 12 million/ml to 60 million/ml, and sperm morphology improved from 65% to 80%. These results underscore the potential of this Ayurvedic formulation in addressing Oligospermia.
Hormonal and Sexual Function Improvements
In addition to improving seminal parameters, the treatment also yielded a notable increase in hormonal levels and sexual function. Total testosterone levels rose from 2.77 ng/ml to 3.04 ng/ml. The comprehensive assessment, using the International Index of Erectile Function (IIEF) questionnaire, indicated an enhancement in sexual performance, with the overall score rising from 29 to 58 over the treatment duration. This highlights that the benefits of "Madhyamapanchamoola Churna" extend beyond just reproductive metrics, positively impacting general sexual health and activity.
Conclusion
The study concludes that "Madhyamapanchamoola Churna" demonstrates significant efficacy in treating Oligospermia, contributing to improvements in seminal quality, hormonal balance, and sexual function without adverse effects. This emphasizes the valuable role of Ayurvedic medicine in managing male infertility disorders, suggesting that herbal remedies could be a fruitful approach for enhancing reproductive health in men.
FAQ section (important questions/answers):
What is the primary focus of the case report?
The case report focuses on the efficacy of Madhyamapanchamoola Churna in treating a 32-year-old male with Oligospermia, highlighting improvements in sperm parameters and successful conception.
What are the main findings related to sperm parameters?
After treatment with Madhyamapanchamoola Churna, sperm concentration improved from 12 million/ml to 60 million/ml, while sperm morphology increased from 65% to 80%, indicating significant enhancement in overall sperm quality.
What are the potential benefits of Madhyamapanchamoola Churna?
Madhyamapanchamoola Churna potentially enhances sperm count, motility, morphology, and testosterone levels while also improving sexual function without adverse effects, making it a valuable treatment for male infertility.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Efficacy of Madhyama Panchamoola Churna in Oligospermia: Case Report�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
A drug refers to any substance used in the treatment, diagnosis, prevention, or cure of diseases. In this study, Madhyamapanchamoola Churna is the drug utilized to treat Ksheenashukra (Oligospermia), showcasing its effect on improving seminal parameters and male fertility.
2) Madhura:
Madhura is one of the six primary tastes in Ayurveda, meaning sweet. It is associated with qualities such as nourishment and rejuvenation. For instance, ingredients like Bala and Eranda have Madhura properties, which contribute to their Shukrala (spermatogenic) activities.
3) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine from India that focuses on balancing bodily systems using diet, herbal treatment, and yogic breathing. This case report demonstrates the efficacy of Ayurveda in treating male infertility through the administration of specific medicinal herbs.
4) Medicine:
Medicine in the context of Ayurveda includes formulations made from natural ingredients to treat various health conditions. Madhyamapanchamoola Churna is an example of such medicine, used to enhance sperm quality and count in the treatment of oligospermia in this study.
5) Shukra (Sukra):
Shukra is the Sanskrit term for semen or sperm, considered crucial for reproduction. In this study, the term is frequently mentioned, particularly in the context of enhancing Shukra quality, concentration, and motility through Ayurvedic treatment.
6) Mudgaparni (Mudga-parni):
Mudgaparni is one of the ingredients in Madhyamapanchamoola Churna. It has properties like Tikta (bitter), Madhura (sweet), Laghu (light), and Rooksha (dry), and contributes to Shukrala (spermatogenic) and Vrushya (aphrodisiac) activities.
7) Mashaparni (Masaparni, Masha-parni):
Mashaparni is another component in Madhyamapanchamoola Churna characterized by Tikta (bitter) and Madhura (sweet) tastes. It is known for its Balya (strengthening) and Shukrajanana (spermatogenic) properties, aiding in the treatment of Ksheenashukra.
8) Punarnava (Punar-nava):
Punarnava is a plant included in the Madhyamapanchamoola Churna formulation. It holds properties like Madhura (sweet) and Tikta (bitter) taste and is known for its Tridoshahara, Deepana, Anulomana, Vrushya, and Rasayana activities, contributing to overall reproductive health.
9) Madhyama:
Madhyama refers to the combination of five herbs (Madhyamapanchamoola) used in this study. It comprises Bala, Punarnava, Eranda, Mudgaparni, and Mashaparni, known for enhancing Shukra quality and aiding in the treatment of oligospermia.
10) Eranda (Eramda):
Eranda (Ricinus communis) is known for its Vatahara, Balya, Vrushya, and Shukrashodhana properties. It is one of the components of Madhyamapanchamoola Churna, which helps in improving sperm volume, count, and motility, as noted in this case report.
11) Bala:
Bala (Sida cordifolia) is a crucial herb in the Madhyamapanchamoola Churna. It has Madhura rasa, Snigdha and Picchila guna, Sheeta veerya, and Madhura vipaka, which contribute to its Vatapittashamaka, Brumhana, Balya, Shukrala, and Ojovardhana properties.
12) Rasayana (Rasa-ayana):
Rasayana refers to the rejuvenation and anti-aging therapies in Ayurveda. Ingredients in Madhyamapanchamoola Churna, like Punarnava, exhibit Rasayana properties, thereby supporting overall vitality and enhancing reproductive health.
13) Ushna (Usna):
Ushna means hot in Ayurveda and describes the heating effect of a substance on the body. For instance, Eranda in the Madhyamapanchamoola Churna has Ushna veerya, contributing to its Vatahara and Shukra-improving properties.
14) Balya:
Balya refers to strength-enhancing properties of a substance. In the context of Madhyamapanchamoola Churna, herbs like Bala and Eranda possess Balya properties, contributing to improved physical strength and semen quality.
15) Food:
In Ayurveda, diet plays a significant role in health. The patient in this study consumed foods classified as Ushna (hot), Katu (pungent), and Amla (sour) rasa, which are identified as contributory factors for Ksheenashukra.
16) Pharmacological:
Pharmacological refers to the properties and effects of drugs. The pharmacological profile of Madhyamapanchamoola Churna's ingredients—such as Bala, Punarnava, and Eranda—demonstrates actions like Shukrala (spermatogenic) and Rasayana (rejuvenative).
17) Dravyaguna (Dravya-guna):
Dravyaguna is a branch of Ayurveda focusing on the properties and actions of medicinal plants. This study on Madhyamapanchamoola Churna was conducted by scholars and professors from the Department of Dravyaguna at the Government Ayurveda Medical College.
18) Karnataka:
Karnataka is an Indian state where the study was conducted. Researchers from Bengaluru, Karnataka, assessed the efficacy of Madhyamapanchamoola Churna in treating oligospermia, contributing valuable insights into Ayurvedic medicine.
19) Anulomana:
Anulomana refers to the regulation of bodily functions, especially digestive and excretory processes. Ingredients like Punarnava and Mudgaparni in Madhyamapanchamoola Churna exhibit Anulomana properties, contributing to overall health and reproductive function.
20) Nagendra (Naga-indra):
Nagendra Chary.M is one of the authors and a Ph.D. Scholar involved in the study assessing the efficacy of Madhyamapanchamoola Churna in treating Ksheenashukra (oligospermia). Contact details are provided for correspondence in the published case report.
21) Vatahara (Vata-ahara):
Vatahara refers to the property of balancing the Vata dosha. Ingredients in Madhyamapanchamoola Churna, such as Eranda, help mitigate Vata-related imbalances, which are essential in treating conditions like Ksheenashukra (oligospermia).
22) Snigdha:
Snigdha means oily or unctuous. It describes the qualities of some ingredients in the Madhyamapanchamoola Churna, like Bala, which possess Snigdha guna, contributing to nourishment and improving Shukra quality.
23) Laghu:
Laghu means light and is a property attributed to certain ingredients in Madhyamapanchamoola Churna, like Mudgaparni, which has Laghu guna, facilitating better digestion and absorption, enhancing overall reproductive health.
24) Tikta:
Tikta means bitter, one of the primary tastes in Ayurveda. Ingredients like Mudgaparni and Mashaparni in Madhyamapanchamoola Churna have Tikta rasa, contributing to their Deepana (enhancing digestion) and Shukrala (spermatogenic) properties.
25) Chary:
Chary refers to Nagendra Chary.M, a Ph.D. scholar who co-authored the study on Madhyamapanchamoola Churna's efficacy in treating Ksheenashukra (oligospermia), showing significant improvements in seminal parameters and overall reproductive health.
26) Rasa (Rasha):
Rasa in Ayurveda refers to the taste of a substance, impacting its effect on the body. Different ingredients in the Madhyamapanchamoola Churna exhibit various Rasa like Madhura (sweet) and Tikta (bitter), each contributing uniquely to its therapeutic effects.
27) Shukrajanana (Shukra-janana, Sukrajanana):
Shukrajanana refers to substances that promote the formation of Shukra (sperm/semen). Ingredients like Mashaparni and Mudgaparni in Madhyamapanchamoola Churna have Shukrajanana properties, aiding in the treatment of oligospermia.
28) Tridoshahara (Tridosahara, Tridosha-hara):
Tridoshahara refers to balancing all three doshas—Vata, Pitta, and Kapha. Punarnava in Madhyamapanchamoola Churna has Tridoshahara properties, providing a holistic approach to enhancing overall health and treating Ksheenashukra.
29) Vitiation (Vitiated):
Vitiation refers to the imbalance or disturbance of doshas in Ayurveda, leading to disease. In the context of this study, vitiation of Vata-pitta dosha is identified as a cause for Ksheenashukra, treated with Madhyamapanchamoola Churna.
30) Desire:
Sexual desire is an essential aspect of reproductive health. The case study highlights that alongside seminal improvements, the patient's sexual desire significantly increased after being treated with Madhyamapanchamoola Churna.
31) India:
India is the country where Ayurveda originated and where this study was conducted. The research on Madhyamapanchamoola Churna's effectiveness in treating oligospermia highlights the potential of traditional Indian medicine in addressing modern health issues.
32) Guna:
Guna refers to the qualities or properties of a substance in Ayurveda. Ingredients in Madhyamapanchamoola Churna have specific guna, like Snigdha (unctuous) and Laghu (light), which contribute to their therapeutic effects on reproductive health.
33) Ricinus communis:
Ricinus communis, or Eranda, is one of the ingredients of Madhyamapanchamoola Churna. It has Vatahara, Balya, Vrushya, and Shukrashodhana properties, which are vital in addressing Ksheenashukra by improving sperm quality and count.
34) Shukrashodhana (Sukrasodhana, Shukra-shodhana):
Shukrashodhana refers to purifying or detoxifying the semen. Eranda, one of the herbs in Madhyamapanchamoola Churna, possesses Shukrashodhana properties, contributing to better sperm health and overall reproductive function.
35) Prajasthapana (Praja-sthapana):
Prajasthapana refers to substances that promote conception and sustain pregnancy. Bala in Madhyamapanchamoola Churna is described as having Prajasthapana properties, aiding in the treatment of infertility and improving reproductive outcomes.
36) Garbhadharana (Garbha-dharana):
Garbhadharana means conception in Ayurveda. The case study discusses how Madhyamapanchamoola Churna improved the patient's semen parameters, ultimately aiding in Garbhadharana and resulting in a successful pregnancy.
37) Dhanvantari (Dhanvamtari):
Dhanvantari is the Hindu god of medicine and an incarnation associated with Ayurveda. The study took place at the Government Ayurveda Medical College, located on Dhanvantari Road, reflecting the rich tradition and continued practice of Ayurvedic medicine.
38) Garbhashaya (Garbhasaya, Garbha-ashaya):
Garbhashaya is the Sanskrit term for the uterus. The study mentions that any impairments related to the uterus (Kshetra) are among the contributing factors to infertility, highlighting Ayurveda's holistic approach to reproductive health.
39) Vatapitta (Vata-pitta):
Vata-pitta refers to two of the three doshas in Ayurveda. The study identifies Ksheenashukra (oligospermia) as being caused by the vitiation of Vata-pitta dosha, which is balanced through the administration of Madhyamapanchamoola Churna.
40) Discussion:
The discussion section of the study elaborates on the traditional Ayurvedic understanding of male infertility and the efficacy of Madhyamapanchamoola Churna in treating Ksheenashukra, outlining the pharmacological properties and observed results.
41) Picchila:
Picchila means slimy or sticky in Ayurveda. Bala in the Madhyamapanchamoola Churna has Picchila guna, which contributes to its nourishing and strengthening properties, beneficial for enhancing Shukra quality in the treatment of Ksheenashukra.
42) Toxicity:
[see source text or glossary: Toxicity]
43) Katurasa (Katu-rasa):
Katurasa means pungent taste in Ayurveda. The patient in the study consumed foods with Katurasa, which are contributory factors for Ksheenashukra, highlighting the importance of dietary considerations in Ayurvedic treatment.
44) Kshetra (Ksetra):
Kshetra refers to the uterus, considered one of the principal factors for conception in Ayurveda. Any impairments in Kshetra can lead to infertility, and addressing these through holistic Ayurvedic treatments like Madhyamapanchamoola Churna is crucial.
45) Sukshma (Suksma, Shukshma):
Sukshma means subtle or penetrative. Eranda in Madhyamapanchamoola Churna has Sukshma guna, which helps in penetrating and treating deep-seated issues like Shukradushti (semen disorder), contributing to improved sperm health.
46) Vyayama:
Vyayama means physical exercise in Ayurveda. The lack of Vyayama in the patient's daily regimen was identified as a contributory factor for Ksheenashukra, underlying the holistic approach Ayurveda takes by considering lifestyle factors in treatment.
47) Anupana:
Anupana refers to the vehicle or medium taken along with the main medication. In this study, Madhyamapanchamoola Churna was administered with cow’s milk as Anupana, highlighting the synergistic role of Anupana in enhancing the drug’s efficacy.
48) Samaka (Shamaka):
Shamaka means pacifying or balancing. Bala and Mashaparni in Madhyamapanchamoola Churna have Vata-pittashamaka properties, which help in balancing the vitiated doshas, crucial for treating conditions like Ksheenashukra (oligospermia).
49) Disease:
Disease in Ayurveda is understood as an imbalance of doshas, dhatus, and malas. In the study, Ksheenashukra (oligospermia) is described as a disease caused by the vitiation of Vatapittadosha, treated effectively with Ayurvedic medicine.
50) Artava:
Artava refers to the ovum or menstrual blood. The study mentions Artava with Shukra (sperm) as one of the essential factors for conception in Ayurveda, emphasizing the holistic approach to treating infertility by addressing multiple reproductive factors.
51) Vipaka:
Vipaka means post-digestive effect in Ayurveda. Ingredients like Bala, Punarnava, and Eranda in Madhyamapanchamoola Churna have Madhura Vipaka, contributing to their nourishing and Shukrala (spermatogenic) properties, crucial for treating Ksheenashukra.
52) Chinta:
Chinta means stress or anxiety in Ayurveda. The study notes that a lack of daily exercise and an increase in Chinta can contribute to conditions like Ksheenashukra, stressing the importance of holistic lifestyle management in Ayurveda.
53) Nature:
Nature refers to the inherent properties of substances or beings. The case report demonstrates the natural therapeutic potential of Ayurvedic herbs like those in Madhyamapanchamoola Churna, highlighting their use in treating reproductive health issues.
54) Kriya:
Kriya refers to actions or therapies in Ayurveda. The treatment line for Ksheenashukra includes Shukrakara-Kriya (actions that enhance Shukra), which Madhyamapanchamoola Churna effectively performs, improving the seminal parameters in the study.
55) Pitta:
Pitta is one of the three doshas in Ayurveda, responsible for metabolism and transformation. The vitiation of Pitta dosha, along with Vata, is identified as a cause of Ksheenashukra (oligospermia), which is balanced through Ayurvedic treatments.
56) Karma (Karman):
Karma in Ayurveda refers to the action or effect of a drug. The study discusses the pharmacological Karma of Madhyamapanchamoola Churna ingredients like Bala, Eranda, and Mudgaparni, which exhibit Shukrala (spermatogenic) activities.
57) Dushta (Dusta):
Dusta refers to impurities or deficiencies. In the context of this study, Dusta Shukra means impure or defective semen, which is addressed using Shukrashodhana and Shukravardhaka properties of herbs in Madhyamapanchamoola Churna.
58) Kumar:
Kumar is part of the name of T. Anil Kumar, one of the co-authors and Professor and HOD at M.S Ramaiah Medical College involved in this study on the efficacy of Madhyamapanchamoola Churna in treating Ksheenashukra (oligospermia).
59) Ayus (Ayush):
[see source text or glossary: Ayush]
60) Blood:
Blood tests were part of the assessment parameters in the study. Hormonal assays including FSH, LH, and total testosterone levels were measured before and after treatment with Madhyamapanchamoola Churna, indicating improvements in reproductive health.
61) Sida (Shida):
Sida cordifolia, commonly known as Bala, is a herb used in Madhyamapanchamoola Churna. It has numerous beneficial properties such as Balya (strengthening), Rasayana (rejuvenative), and Shukrala (spermatogenic), essential for treating Ksheenashukra.
62) Bahu:
Bahu means large quantity in Ayurveda. Bahu guna is associated with Shukra, implying good semen volume and concentration, which were notably increased in the patient after treatment with Madhyamapanchamoola Churna.
63) Katu:
Katu means pungent, one of the six tastes in Ayurveda. The patient's regular dietary intake of Katu Rasa (pungent foods) was identified as a factor contributing to Ksheenashukra, demonstrating the role of diet in Ayurvedic diagnosis and treatment.
64) Amla:
Amla means sour, another key taste in Ayurveda. The patient's dietary habit of consuming Amla Rasa (sour foods) was cited as a contributory factor to Ksheenashukra, highlighting the necessity of dietary modifications in Ayurvedic treatment.
65) Vata:
Vata is one of the three doshas in Ayurveda, responsible for movement and communication. The vitiation of Vata dosha is one of the causes of Ksheenashukra (oligospermia), which Madhyamapanchamoola Churna aids in balancing through its Vatahara properties.
66) Alpa:
[see source text or glossary: Alpa]
67) Ambu:
Ambu refers to the nutritional factors in Ayurveda, providing the necessary nourishment to the tissues including Shukra (semen). Ensuring adequate Ambu is crucial for treating conditions like Ksheenashukra, which respond well to therapy with Madhyamapanchamoola Churna.
68) Milk:
Milk is used as Anupana (vehicle) in the administration of Madhyamapanchamoola Churna. Cow’s milk was taken before food twice daily, enhancing the efficacy of the treatment in improving seminal parameters and overall reproductive health.
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