Efficacy and safety of AmpuCare for various wound types.
Journal name: World Journal of Pharmaceutical Research
Original article title: Clinical efficacy and safety of ampucare in treatment of different kinds of wounds
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Rama Krishna Gupta and Hemlata Gupta
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Clinical efficacy and safety of ampucare in treatment of different kinds of wounds
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201717-10307
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Chronic wounds are categorized as wounds that fail to heal within a predictable timeframe, often not improving after four weeks and not healing in eight weeks. Common wound types include surgical, traumatic, diabetic, venous, arterial, and pressure ulcers. Wound management aims to avoid infection and achieve functional and cosmetically acceptable scars. This study evaluates the clinical efficacy and safety of Ampucare, an AYUSH-approved polyherbal formulation, in treating various types of wounds, analyzing data from 1328 patients treated between April 2013 and March 2017. The study highlights the significant reduction in wound size and the safety of Ampucare.
Efficacy of Ampucare in Healing Various Wounds
The retrospective study demonstrates that Ampucare is highly effective in managing different types of wounds, with varying degrees of success across wound categories. Specifically, burn patients showed the most significant recovery, with a 95.1% reduction in wound size within an average treatment duration of 38 days. Bedsore (pressure ulcers) followed closely with a 93.8% reduction seen over 60 days. Diabetic wounds showed an 88.4% reduction after 47 days, while traumatic wounds exhibited an 86.1% reduction in size over 28 days. These results indicate that Ampucare significantly enhances the healing process, particularly in severe cases.
Safety and Tolerance of the Treatment
Ampucare was assessed for its safety and tolerance among patients with various wounds. The formulation is derived from natural ingredients, which reduces the likelihood of adverse side effects typically associated with chemical treatments. The study included patients with conditions of low immunity, such as cancer, indicating its suitability for a wider demographic. The authors emphasized that no hypersensitivity reactions were recorded during the treatment, which strengthens the recommendation for its use in clinical settings.
Role of Antioxidants and Herbal Ingredients in Wound Healing
The study highlights the importance of antioxidants and anti-inflammatory properties present in the components of Ampucare. Key ingredients include Curcuma longa, Azadirachta indica, and Trichosanthes dioica, which collectively contribute to antimicrobial activity, promote cellular proliferation, and enhance collagen synthesis at the wound site. These herbal constituents have been shown to facilitate essential physiological processes like inflammation, granulation, and re-epithelialization which are vital for effective wound healing.
Conclusion
The findings of this study strongly support the use of Ampucare as an effective, safe, and well-tolerated treatment option for various types of wounds. Unlike traditional wound management strategies that rely on chemical agents, Ampucare offers a cost-effective solution with minimal side effects. The retrospective analysis of patient outcomes increases confidence in recommending this herbal formulation in clinical practices, especially in settings where conventional treatments may be inadequate or unsafe for patients with complex medical histories. This positions Ampucare as a valuable adjunct in modern wound care management.
FAQ section (important questions/answers):
What is the purpose of the study on Ampucare?
The study aimed to analyze the efficacy and safety of Ampucare in treating various acute and chronic non-healing wounds, including those from surgery, trauma, diabetes, burns, and cancer.
What types of wounds were evaluated in the study?
The study evaluated traumatic wounds, bedsores (pressure ulcers), diabetic wounds, burn wounds, gangrene, and cancer-related wounds among 1328 patients treated between April 2013 and March 2017.
How effective is Ampucare in wound healing?
Ampucare showed significant effectiveness with highest recovery rates in burn patients (95.1%) followed by bedsores (93.8%) and gangrene (92.8%), demonstrating its strong wound healing capabilities across various conditions.
What are the main ingredients of Ampucare?
Ampucare contains active ingredients such as Azadirachta indica, Curcuma longa, and Trichosanthes dioica, which offer antimicrobial, antioxidant, and anti-inflammatory properties crucial for effective wound healing.
What was the gender distribution of patients in the study?
Among the 1328 patients, 69.95% were male and 30.04% were female, indicating a higher incidence of moderate to severe wounds in males.
What were the key findings regarding wound treatment duration?
The study found that the duration of treatment varied. Burn patients required an average of 38 days, while diabetic wounds took 47 days, demonstrating varying healing times based on wound type.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Efficacy and safety of AmpuCare for various wound types.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Burning (Burn, Burned, Burnt):
Burns are traumatic injuries caused by exposure to thermal, electrical, chemical, or electromagnetic energy. The severity of burns can vary, but they often require specialized treatment to prevent infection and promote healing. In the context of the study, burn patients benefited significantly from the herbal formulation Ampucare, showcasing its efficacy in wound healing.
2) Ulcer:
An ulcer is a sore that develops on the skin or mucous membranes, often due to underlying health conditions. Diabetic ulcers, for example, result from prolonged high blood sugar levels affecting blood flow and healing. The study evaluated Ampucare's effectiveness specifically in diabetic wound management, emphasizing its therapeutic potential.
3) Study (Studying):
The study documented herein was a retrospective analysis concerning the efficacy and safety of Ampucare in treating various types of wounds among patients. Such studies collect and evaluate existing data to understand treatment outcomes better, guiding future medical practices and therapeutic applications for diverse patient populations.
4) Activity:
The term 'activity' in this context refers to the functional actions or effects of Ampucare on wound healing processes. It implies the biochemical and physiological responses elicited by the powder, leading to various positive healing outcomes when utilized in treating different types of wounds in patients.
5) Krishna (Krsna):
Rama Krishna Gupta is the principal author and researcher behind the study evaluating Ampucare. His work represents a significant contribution to traditional and herbal medicine, exploring how indigenous formulations can enhance treatment for complex conditions like chronic wounds, leading to efficient healing without adverse effects.
6) Cancer:
Cancer patients frequently experience wounds resulting from various treatment modalities and low immunity. The study included such patients to gauge the effectiveness of Ampucare in promoting wound healing while they underwent therapies. Successful wound management is crucial for maintaining quality of life in cancer care.
7) Table:
Tables in the report present structured data, making complex information more accessible. For instance, they summarize patient demographics, types of wounds, and healing outcomes, enabling readers to quickly comprehend vital statistics and findings of the study, facilitating better understanding of Ampucare's efficacy.
8) Gwalior:
The research was conducted in hospitals located in Gwalior, India, a city known for its medical facilities. The geographical aspect is significant as it reflects the local health challenges and the specific population dynamics, influencing the types of wounds addressed and the outcomes of herbal treatments.
9) Male:
A significant portion of the study's participants were male, accounting for approximately 69.95% of the total patient cohort. The male population faced various wound types, with specific injury patterns observed. Gender-specific data help tailor treatment strategies to enhance healing outcomes effectively.
10) Trichosanthes dioica:
Trichosanthes dioica, included in the Ampucare formulation, possesses notable wound healing properties. This herb is recognized for its ability to promote collagen synthesis and cellular proliferation at the wound site, making it a vital component in improving recovery rates in patients undergoing treatment.
11) Drug:
Ampucare is classified as a drug (herbal formulation) aimed at enhancing wound healing. Unlike conventional medicines with potential side effects, this formulation reflects a shift towards using natural compounds, emphasizing its role in holistic and safer treatment approaches for various types of wounds.
12) Azadirachta indica:
Commonly known as neem, Azadirachta indica contributes antibacterial and anti-inflammatory properties to Ampucare. Its inclusion in the wound treatment formulation signals the importance of herbal agents in modern medicine, combining traditional knowledge with contemporary therapeutic practices to address infections effectively.
13) Post:
The term 'post' relates to the evaluation phase of the study, particularly emphasizing post-treatment assessments of wounds after application of Ampucare. Evaluative measures ensured that outcomes were quantified, aiding in the validation of the formulation's effectiveness and its clinical implications for future therapies.
14) Curcuma longa:
Curcuma longa, or turmeric, is celebrated for its anti-inflammatory and healing properties. In the context of Ampucare, it acts synergistically to support wound recovery processes, minimizing inflammation while promoting healing, essential for patients suffering from various types of wounds as shown in the study.
15) Aureus:
Staphylococcus aureus is a commonly found bacterium involved in wound infections. Its presence can complicate healing processes. The study highlights how Ampucare's formulation combats such infections, underscoring the importance of effective antimicrobial action in treating different wound types.
16) Indian:
The study focuses on Indian patients and their unique health challenges, particularly regarding wound healing. It reflects the integration of traditional herbal formulations like Ampucare within the healthcare system, aiming to utilize local resources and historical knowledge in modern clinical practice for better health outcomes.
17) Antibiotic (Antibacterial):
Recent advances underscore the importance of appropriate antibiotic use in managing traumatic wounds. The study indicates that while patients received antibiotic treatment, Ampucare served as a comprehensive solution for infection control and healing, minimizing the need for extensive antibiotic therapies.
18) Inflammation:
Inflammation is a natural response to injury or infection but can hinder the healing process if uncontrolled. Ampucare includes anti-inflammatory agents that help regulate this response, thus facilitating quicker recovery while minimizing discomfort for patients dealing with various types of wounds.
19) Chauhan:
Chauhan is referenced within the study as an author or significant contributor to the body of research surrounding pressure ulcers and their management. Citing previous studies provides a foundation for understanding the ongoing challenges and advancements in wound treatment approaches.
20) Gupta:
Rama Krishna Gupta, as the principal author of the study, is a significant figure in exploring and validating herbal treatments for wounds in clinical settings. His contributions highlight the effectiveness of traditional medicines, thereby supporting their inclusion in contemporary healthcare practices.
21) Suffering:
Patients suffering from various types of wounds were the focus of the study, illustrating the lived experiences of individuals facing chronic health issues. Their responses to treatment were analyzed to determine the efficacy of Ampucare, signifying the human aspect of medical research.
22) Medicine:
The role of medicine, particularly herbal medicine, is critically evaluated in the study. Ampucare showcases how herbal formulations can serve as effective alternatives or complements to conventional drugs in wound management, thus promoting a broader understanding of therapeutic options available in healthcare.
23) Species:
References to species, such as those affected by S. aureus and other pathogens in the study, illustrate the variability and complexity of wound infections. Understanding these biological entities helps healthcare providers tailor treatments to target specific infections effectively, enhancing recovery rates.
24) Wounded:
Wounded individuals, particularly those with non-healing injuries, are the central subjects of this study. Their experiences and treatment outcomes inform the research on Ampucare, demonstrating the product's relevance in addressing the needs of this demographic within healthcare.
25) Surface:
Surface area of wounds is a critical factor in determining healing outcomes and treatment efficacy. By measuring the surface area, the study could quantify the effectiveness of Ampucare in promoting healing, enabling healthcare professionals to assess and compare therapeutic strategies effectively.
26) Repair:
Repair mechanisms are crucial in wound healing, encompassing various biological processes involved in tissue regeneration. The study emphasized how Ampucare facilitated these processes, showcasing its ability to enhance skin repair and restore function, a vital aspect of effective wound management.
27) Sidhu (Shidhu):
Sidhu is referenced regarding earlier studies that explored the healing properties of components in Ampucare. His findings contribute to understanding the scientific basis for the formulas used and strengthen the rationale for employing herbal treatments in modern medicine.
28) India:
The focus on India as a backdrop for the study highlights the region's unique healthcare challenges and the significance of using indigenous herbal formulations like Ampucare to address specific wound-related issues faced by the local population.
29) Rama:
Rama Krishna Gupta, the lead researcher, plays a pivotal role in advancing knowledge of herbal treatment modalities, further emphasizing the importance of innovative approaches in wound management, particularly within the context of Indian traditional medicine integrating with modern healthcare practices.
30) Accumulation (Accumulating, Accumulate):
Accumulation of cells such as neutrophils and other inflammatory markers occurs during the wound healing process. Excessive accumulation can lead to chronic inflammation and delayed healing; hence, reducing this accumulation is a key function of formulations like Ampucare to achieve optimal recovery.
31) Transformation (Transform, Transforming):
The term 'transforming' refers to vital growth factors involved in tissue repair. Ampucare acts on transforming processes within the body to enhance healing, illustrating the importance of supporting cellular mechanisms that contribute to effective recovery in wound management.
32) Discussion:
The discussion section of the study is crucial in interpreting data results and exploring the implications of findings. It helps readers understand how Ampucare operates at multiple healing levels and contextualizes its role within broader medical and herbal treatment practices.
33) Collecting:
Collecting data is an essential part of conducting retrospective studies, enabling researchers to analyze patient outcomes systematically. This study involved collecting data from multiple hospitals to assess the safety and efficacy of Ampucare, emphasizing the importance of comprehensive data in validating treatments.
34) Substance:
The term 'substance' here refers to the ingredients within Ampucare, emphasizing the importance of their individual and collective contributions to the formulation's efficacy in wound healing. Understanding various substances helps in advancing medical research and developing effective therapeutic agents.
35) Toxicity:
Toxicity is a crucial consideration when assessing any treatment's safety profile. In the context of the study, it highlights the importance of herbal formulations like Ampucare, which offer effective wound care solutions with reduced toxicity compared to conventional chemical treatments.
36) Dressing:
Dressing refers to the method of applying a topical treatment to a wound. In the study, Ampucare was used as a dressing for various types of wounds, showcasing its relevance in facilitating healing while providing a protective barrier against infection.
37) Incision:
Incisions are surgical cuts made during procedures. Understanding the nature of incisions is vital as they can lead to surgical wounds requiring careful management. The study highlights how Ampucare can aid in healing post-incisional wounds, reinforcing the need for effective treatment applications.
38) Lakshmi (Laksmi):
Lakshmi is mentioned in the context of prior studies addressing herbal contributions to wound healing. By integrating previous research findings, the work increases the credibility of using herbal treatments, showcasing the need for a comprehensive understanding of their roles in modern healthcare.
39) Disease:
Disease often predisposes individuals to wounds or affects healing times. The study accounts for background diseases like diabetes when evaluating treatment effects of Ampucare, underlining the need for customized wound care that factors in patients' overall health conditions.
40) Thomas:
Thomas is referenced to validate previous findings related to pressure sores, reinforcing the ongoing challenges in wound management. Recognizing past research helps contextualize the current study's findings on Ampucare, emphasizing the importance of continuing research on effective treatments.
41) Killing (Killed):
Killed refers to the detrimental effects of excessive inflammation or infection during wound healing, potentially leading to tissue destruction. The study emphasizes how Ampucare mitigates these risks, hence promoting a healthier healing environment and improving recovery outcomes for patients.
42) Kumar:
Kumar is cited within the study to support claims regarding the efficacy of herbal treatments like Ampucare. His reference aligns with a broader narrative about the benefits of traditional medicine, fostering a greater acceptance and understanding of such remedies within contemporary healthcare.
43) Ayus (Ayush):
Ayush represents a system of traditional medicine in India that encompasses alternative therapies, including herbal medicine. The support from Ayush regulatory bodies enhances the credibility of treatments like Ampucare, promoting their adoption within mainstream medical practices in India.
44) Visit:
The term 'visit' suggests patient interactions within healthcare settings, particularly relating to wound care services. It emphasizes the importance of medical visits for ongoing assessments and treatments, underpinning the patient-centered approach fundamental to effective healthcare delivery.
45) Blood:
Blood is integral to the wound healing process, providing oxygen and essential nutrients to tissues. The study highlights the importance of maintaining adequate blood supply in healing wounds, showcasing the interplay between systemic health and effective wound management.
46) Beta:
Beta refers to transforming growth factors involved in tissue repair and regeneration. The action of such factors is enhanced by the herbal ingredients in Ampucare, leveraging their properties to optimize wound healing processes as explored in the study.
47) Sign:
Sign relates to clinical indicators of wound healing progress. By tracking signs of improvement, the study could quantify the efficacy of Ampucare, validating its role in facilitating recovery and establishing benchmarks for future wound care methodologies.
48) Line:
Line indicates the essential boundaries within which the study operates, defining the scope of the research regarding Ampucare and its applications. Establishing a clear line helps focus the investigation and delineates areas for future inquiry in wound healing.
49) Pain:
Pain management is a critical component of wound care, significantly affecting patient experiences and healing outcomes. Addressing pain effectively is paramount, and the study suggests that Ampucare also contributes to pain relief, enhancing overall patient satisfaction during the recovery process.
50) Pur:
Poor wound healing outcomes present a significant challenge in clinical settings. The study addresses this challenge by evaluating Ampucare's effectiveness in improving healing rates, aiming to provide solutions for patients suffering from non-healing wounds and enhancing overall quality of care.
Other Science Concepts:
Discover the significance of concepts within the article: �Efficacy and safety of AmpuCare for various wound types.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Acute and chronic, Topical application, Wound healing, Historical data, Dosage schedule, Clinical efficacy, Active ingredient, Pressure Ulcer, Retrospective study, Ayush approved, Evaluation of efficacy, Healing potential, Synergistic activity, Poly Herbal Formulation, Diabetic wound, Gangrene, Non healing wound, Male Female Ratio.