365betÓéÀÖ

Phytochemical screening and bioactivity of Trichodesma indicum shoots.

| Posted in: Science

Journal name: Ancient Science of Life
Original article title: Phytochemical screening and antioxidant, antimitotic, and antiproliferative activities of Trichodesma indicum shoot
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Shweta S. Saboo, Ganesh G. Tapadiya, Jasvant J. Lamale, Somshekhar S. Khadabadi


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Phytochemical screening and antioxidant, antimitotic, and antiproliferative activities of Trichodesma indicum shoot

Year: 2014

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study investigates the phytochemical properties and potential therapeutic effects of Trichodesma indicum, a plant traditionally utilized in folk medicine for its anti-inflammatory, analgesic, and anticancer activities. Despite its historical use, there has been limited scientific validation of its anticancer potential. The research aimed to examine the antioxidant, antimitotic, and antiproliferative activities of various extracts from the aerial parts of T. indicum to establish its viability as a candidate for cancer treatment.

Antioxidant and Anticancer Activities

The extracts of T. indicum—obtained through sequential extraction methods—were found to possess significant antioxidant properties, with varying levels of total phenolics and flavonoids across the extracts. A crucial aspect of the study was the evaluation of the extracts' antimitotic and antiproliferative effects. Using various bioassays, including the Allium cepa root mitotic assay and tests on several human cancer cell lines (MCF-7, HOP-62, MOLT-4, HCT-15, and PRO), the researchers discovered that the successive ethanol extract exhibited the strongest inhibitory activities against breast cancer (MCF-7) and leukemia (MOLT-4) cell lines. This suggests that the presence of phytochemicals such as gallic acid, catechin, and β-sitosterol may be responsible for the observed anticancer effects, supporting claims of the plant’s traditional usage.

Conclusion

The findings of this research substantiate the traditional application of Trichodesma indicum in cancer treatment by demonstrating its significant antioxidant, antimitotic, and antiproliferative activities, particularly against certain cancer cell lines. The study highlights the therapeutic potential of this plant as a new anticancer agent, indicating that further investigations—both in vitro and in vivo—are imperative to elucidate the precise mechanisms of action and to assess its practical applications in modern medicine.

FAQ section (important questions/answers):

What traditional uses are associated with Trichodesma indicum?

Trichodesma indicum has been traditionally used for its anti-inflammatory, analgesic, and anticancer properties in folk medicine. It's Particularly known for treating joint swelling and has been utilized for cancer treatment.

What methods were used for evaluating the plant's activities?

The study used several methods to assess Trichodesma indicum's activities, including in vitro antioxidant assays, antimitotic activity in Allium cepa roots, and antiproliferative assays using yeast and five human cancer cell lines.

What were the key findings regarding its anticancer potential?

The extracts showed significant antimitotic and antiproliferative activities, with the ethanol extract demonstrating strong inhibition against MCF-7 and MOLT-4 cell lines. Phytochemical analysis revealed the presence of compounds like β-sitosterol, gallic acid, and catechin.

What further research is recommended based on the findings?

Further experiments are needed to explore the detailed mechanisms of action both in vitro and in vivo. These would help validate Trichodesma indicum as a potential new anticancer drug.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Phytochemical screening and bioactivity of Trichodesma indicum shoots.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Cancer:
Cancer is a major health issue characterized by the uncontrolled growth of abnormal cells. The text emphasizes the urgent need for new treatments, including botanical remedies. Understanding cancer's nature is vital for developing effective therapeutic strategies, highlighting a key focus in the study of psychopharmacology and medicinal plants.

2) Activity:
Activity refers to the biological effects or responses observed from the extracts of Trichodesma indicum in various assays, including antimitotic and antiproliferative effects. The study measures these activities quantitatively, aiming to validate traditional uses of the plant and its potential as a therapeutic agent against cancer.

3) Water:
In the context of the study, water refers to the solvent used for extracting beneficial compounds from Trichodesma indicum. The aqueous extract is vital for assessing the plant's broad spectrum of phytochemicals, which may contribute to its pharmacological properties and efficacy in traditional medicine applications.

4) Phytochemical:
Phytochemicals are bioactive compounds derived from plants that offer various health benefits. In this research, the presence of phytochemicals like flavonoids and alkaloids in Trichodesma indicum is essential for understanding its therapeutic potential, particularly antioxidant and anticancer properties that can serve as a basis for new treatments.

5) Drug:
Drug refers to any substance used for medical treatment. In the context of this study, the extracts from Trichodesma indicum are analyzed for their potential as a new anticancer drug, which could lead to safer and more effective therapeutic options by utilizing natural plant-derived compounds for cancer treatment.

6) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing disease. This study explores the traditional usage of Trichodesma indicum in folk medicine, validating its applications with scientific evidence, which signifies a bridge between traditional knowledge and modern medical practices in the realm of cancer treatment.

7) Flavonoid:
Flavonoids are a class of phytochemicals known for their health benefits, including antioxidant and anti-inflammatory properties. The study highlights the presence of flavonoids in Trichodesma indicum, suggesting their potential role in inhibiting cancer cell growth and reinforcing the need for further exploration of these compounds in therapeutic contexts.

8) Surana (Shurana):
Surana refers to a method or protocol developed by researchers, specifically mentioned in the antioxidant assays conducted in the study. The reference to Surana emphasizes the importance of established scientific techniques in validating experimental results, enhancing the reliability of findings regarding the medicinal efficacy of Trichodesma indicum.

9) Chemotherapy:
Chemotherapy is a common cancer treatment involving the use of drugs to kill or slow the growth of cancer cells. The text discusses the limitations of conventional chemotherapy, making a case for exploring alternative treatments, like those derived from natural sources, to improve patient outcomes and reduce side effects.

10) Radiotherapy:
Radiotherapy is another primary modality for cancer treatment that uses high doses of radiation to kill cancer cells. Alongside chemotherapy, its mention in the study underscores the ongoing search for more effective and accessible treatment options, as current therapies often come with significant costs and side effects.

11) Discussion:
Discussion in scientific research pertains to the interpretation of results, implications of findings, and suggestions for future research. In this study, the discussion emphasizes the validation of Trichodesma indicum's traditional uses and suggests further exploration into its mechanisms and potential as a viable alternative cancer treatment.

12) Swelling:
Swelling typically refers to the enlargement of body parts usually due to inflammation. In the context of Trichodesma indicum's traditional uses, its role in reducing swelling showcases its therapeutic relevance in folk medicine, which the study aims to confirm scientifically for broader applications in treating inflammatory conditions.

13) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world. In this context, the study exemplifies how scientific methodologies are applied to validate traditional medicinal practices, highlighting the critical role of scientific inquiry in unlocking the therapeutic potential of herbal medicine.

14) Reason:
Reason refers to the underlying logic or rationale behind exploring Trichodesma indicum for its medicinal properties. The study's reason centers on addressing the high incidence of cancer and the need for more accessible and affordable treatment options, thus triggering research into plant-based alternatives that align with traditional uses.

15) Botany:
Botany is the branch of biology that studies plants, their structure, properties, and biochemical processes. The research significantly relies on botanical knowledge to authenticate Trichodesma indicum and understand its phytochemistry, thereby integrating botany with pharmacognosy in the pursuit of developing effective natural medicines.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: �Phytochemical screening and bioactivity of Trichodesma indicum shoots.�. Further sources in the context of Science might help you critically compare this page with similair documents:

Antioxidant activity, Phytochemical analysis, Traditional System of Medicine, Cytotoxic activity, IC50 value, Gallic acid, Free Radical, Catechin, Natural product chemistry, Antiproliferative activity, Antimitotic activity, Beta-Sitosterol, In vitro assay, Therapeutic utilities, Cell line, Microtubules.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: