Significance of Cytotoxic activity
Cytotoxic activity refers to a substance's ability to kill or inhibit the growth of cells, particularly cancer cells. This capability is assessed through various methods such as MTT assays and bioassays using model organisms like brine shrimp. Numerous studies have highlighted specific substances, including extracts from plants like Basella alba and Curculigo orchioides, exhibiting significant cytotoxic properties against cancer cells. Understanding cytotoxic activity is crucial for evaluating potential anticancer agents and their therapeutic efficacy.
Synonyms: Cytotoxicity, Cytolytic activity, Cell toxicity, Cytopathic effect
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The concept of Cytotoxic activity in scientific sources
Cytotoxic activity encompasses a substance's ability to induce cancer cell death and demonstrate toxicity to cells through bioassays, exemplified by studies on the aqueous extract of Phanera vahlii against PC-3 cells.
From: The Malaysian Journal of Medical Sciences
(1) Di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives possess this specific effect, and they also have the potential to induce apoptosis.[1] (2) The capability of a substance to cause harm or damage to cells was demonstrated in studies involving pulegone and its metabolic byproducts, showing its effect on specific cell types.[2] (3) This refers to the ability of the tamarillo extracts to kill or inhibit the growth of cells, particularly cancer cells, indicating their potential anticancer properties.[3] (4) The ability to kill cells, particularly cancer cells, as exhibited by NDV-activated macrophages and natural killer cells in the context of anti-tumor actions.[4] (5) The ability of substances to kill or inhibit the growth of cells, particularly cancer cells, often assessed in treatments.[5]