Hepatoprotective effect of Gumma against CCl4-induced liver damage
Journal name: Ancient Science of Life
Original article title: Hepatoprotective activity of Gumma (Leucas cephalotes Spreng.) against Carbon tetrachloride induced hepatotoxicity in wistar rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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G. Sofi, Mohd. Yasir Khan, M. A. Jafri
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Hepatoprotective activity of Gumma (Leucas cephalotes Spreng.) against Carbon tetrachloride induced hepatotoxicity in wistar rats
Year: 2011
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study focuses on the hepatoprotective effects of Gumma (Leucas cephalotes Spreng.) against hepatotoxicity induced by carbon tetrachloride (CCl�) in Wistar rats. Given its historical usage in Unani medicine for liver ailments, the research aims to objectively evaluate its protective potential when faced with chemically induced liver damage. The study employed a hydro-alcoholic extract of Gumma administered at a dosage of 583 mg/kg, examining its efficacy through biochemical markers of liver function and histopathological assessments.
Hepatoprotective Efficacy of Gumma
The findings reveal that Gumma significantly mitigates the damage caused by CCl�, as evidenced by normalized levels of liver function markers including serum bilirubin, AST, ALT, and ALKP in the treated rats compared to control groups. Histological evaluations demonstrated that pre-treatment with Gumma preserved liver architecture, showing no significant damage, while the negative control group exhibited extensive hepatocellular injury. The study also indicated that the prophylactic administration of the extract provided better protection than therapeutic intervention after damage was induced, suggesting the extract's potent preventive qualities against oxidative stress and hepatotoxicity.
Conclusion
In conclusion, the research establishes that Gumma (LCS) offers significant hepatoprotective benefits against CCl� induced hepatotoxicity. These protective effects are attributed to the extract's potential antioxidant properties, which help counteract oxidative stress associated with liver damage. The results endorse the use of Gumma as a preventive agent in managing liver diseases and underline the necessity for further studies to explore the specific chemical constituents responsible for its hepatoprotective activity.
FAQ section (important questions/answers):
What is the objective of the hepatoprotective study on Gumma?
The study aimed to evaluate the hepatoprotective activity of Gumma (Leucas cephalotes) against carbon tetrachloride (CCl4) induced hepatotoxicity in Wistar rats.
How was the hepatotoxicity induced in the study?
Hepatic damage was induced in Wistar rats by administering carbon tetrachloride (CCl4) at a dosage of 0.7ml/kg daily through intraperitoneal injection.
What were the findings regarding liver function markers?
The hydro alcoholic extract of Gumma significantly lowered serum markers like Bilirubin, AST, ALT, and ALKP in chemically challenged animals, suggesting effective hepatoprotection.
Was there a difference in results between pre-treated and post-treated groups?
Yes, the pre-treated group showed more significant hepatoprotection compared to the post-treated group, indicating that preventative treatment was more effective than treatment after damage occurred.
Other Science Concepts:
Discover the significance of concepts within the article: �Hepatoprotective effect of Gumma against CCl4-induced liver damage�. Further sources in the context of Science might help you critically compare this page with similair documents:
Hepatotoxicity, Hepatoprotective activity, One-way ANOVA, Hydro alcoholic extract, Histopathological examination, Liver function test, Serum markers, Negative control group, Wistar rat, Pre-treated group, Post-treated group, Significant pathology, Dunnett's Multiple Comparison Test, Carbon tetrachloride (CCl4), Plain control group.