Significance of Hepatotoxicity
Hepatotoxicity refers to the potential for substances to cause damage to the liver, often identified by increased liver enzyme levels. It encompasses liver damage resulting from exposure to various chemicals, medications, or toxins. This condition can arise from prolonged use of certain drugs, such as DMARDs and paracetamol, and can have serious health implications. Toxic substances like carbon tetrachloride, chemotherapy agents, and even plant extracts can lead to hepatotoxicity, necessitating protective measures to mitigate liver injury.
Synonyms: Liver toxicity, Liver damage, Hepatocellular injury, Hepatic toxicity, Liver impairment
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Hepatotoxicity in scientific sources
Hepatotoxicity involves liver damage from chemicals, drugs, or toxins, indicated by elevated liver enzymes. It is particularly significant in medication side effects, such as with DOTS and long-term DMARD use, leading to various health complications.
From: The Malaysian Journal of Medical Sciences
(1) This is the damage to the liver, which tannins may help prevent.[1] (2) This refers to the damage to the liver, and the treatment with P. betle extract showed hepatotoxicity based on the liver enzymes and endogenous antioxidant level.[2] (3) This is a condition that is induced by paracetamol, and it is studied in Sprague-Dawley rats, and also caused by oral acetaminophen administration in rats.[3] (4) Liver damage caused by certain dietary supplements, especially noted with products containing camellia sinensis (green tea).[4] (5) Liver toxicity that can occur with certain substances, including some components derived from plants.[5]