Uterine changes in rats: effect of Moringa oleifera extract.
Journal name: Ancient Science of Life
Original article title: Pre and post-implantation changes in the uteus of rats: response to moringa oleifera lam. extract
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Anand O. Prakash, Sandhya Pathak, Sangeeta Shukla, R. Mathur
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Pre and post-implantation changes in the uteus of rats: response to moringa oleifera lam. extract
Year: 1988
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigates the effects of the aqueous extract of Moringa oleifera Lam. on the biochemical changes in the uterus of pregnant rats during the pre and post-implantation stages. Moringa oleifera, known as drumstick or Sahajana, has been categorized as an abortifacient based on various reports of its antifertility activity. Despite some conflicting evidence regarding its efficacy, this research aims to elucidate the mechanisms by which Moringa oleifera may induce antifertility effects in laboratory animals by examining its impact on crucial biochemical constituents in the uterus.
Impact on Biochemical Constituents
One critical finding of the study is the significant reduction of total proteins, glycogen content, and the activities of acid and alkaline phosphatase in the uteri of treated rats when compared to control groups. The research shows that while biochemical concentrations in the uteri of control pregnant rats increased progressively during early pregnancy stages, the levels remained significantly lower in rats administered with the aqueous extract of Moringa oleifera. These reductions indicate that the extract interferes with essential biochemical transformations required for successful implantation and nourishment of the developing blastocysts. The diminished levels of proteins and glycogen, along with reduced enzyme activities, suggest a non-receptive uterine environment that impedes the proper implantation and development of fertilized eggs, thereby contributing to infertility.
Conclusion
The findings highlight the antifertility potential of Moringa oleifera through its inability to induce necessary biochemical changes in the uterus for accommodating fertilized eggs. The study demonstrates that the aqueous extract compromises the uterine conditions by lowering key biochemical constituents essential for supporting early pregnancy stages. As a result, the research substantiates the claim that Moringa oleifera exhibits antifertility activity, particularly through mechanisms that create a hostile environment for the implantation of developing embryos, ultimately leading to infertility.
FAQ section (important questions/answers):
What is the purpose of the Moringa oleifera Lam. extract study?
The study investigates the antifertility effects of aqueous extract of Moringa oleifera Lam. on pre and post-implantation changes in the uterus of pregnant rats.
How was the experiment conducted on the rats?
Mature female albino rats were administered a 200 mg/kg dose of Moringa oleifera extract orally during different pregnancy stages, and the uterus was analyzed for biochemical changes after treatment.
What biochemical changes were observed in the treated rats?
Reduced total proteins, glycogen content, and significantly lower activity of acid and alkaline phosphatase were observed in the rats treated with Moringa oleifera extract compared to control groups.
What conclusions were drawn regarding the extract's impact on fertility?
The aqueous extract of Moringa oleifera Lam. appears to disrupt biochemical transformations necessary for embryo implantation, leading to ineffective uterine conditions and potential infertility.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淯terine changes in rats: effect of Moringa oleifera extract.鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In the context of the study, 'Activity' refers to the biochemical processes and enzymatic functions observed in the uterus during the pre and post-implantation phases of pregnancy. The study emphasizes how the administration of Moringa oleifera Lam. extracts influences the enzymatic activity vital for reproductive functions and successful implantation.
2) Post:
The term 'Post' is used here to identify the stages following the initial event in the study, specifically referring to the post-coitum or post-implantation phases in the pregnancy of rats. It is crucial for understanding the timing of biochemical changes in the uterus after fertilization.
3) Transformation (Transform, Transforming):
In the study, 'Transformation' indicates the biochemical changes in uterine tissues during the implantation phases. The authors explore the significance of these transformations in relation to the increasing or decreasing concentrations of proteins, glycogen, and enzyme activities, pivotal for the implantation process in pregnant rats.
4) Discussion:
'Discussion' is a vital section in scientific articles, allowing authors to interpret findings, compare with existing literature, and propose implications. The authors analyze observed biochemical changes due to Moringa oleifera Lam., relating them to antifertility effects and the physiological adaptations required for successful implantation.
5) Sandhya (Sandhy膩, Shandhya, Samdhya):
'Sandhya' appears as part of the authors' names, specifically one of the researchers involved in the study. Acknowledging researchers is common in scientific texts, highlighting individual contributions to the knowledge base regarding the antifertility effects of Moringa oleifera through rigorous experimentation.
6) Zoology:
'Zoology' is the branch of biology that focuses on animals and their biological processes. The relevance here reflects the study's connection to reproductive biology, showcasing the importance of animal models (in this case, rats) in understanding broader biological and reproductive functions relevant to humans.
7) Science (Scientific):
'Science' denotes the systematic study of the natural world through observation and experimentation. This term is relevant as the study exemplifies scientific inquiry into the antifertility potential of Moringa oleifera, contributing to the body of scientific knowledge concerning plant-based reproductive health interventions.
8) Shukla (艢ukla, 艢ukl膩, Sukl膩, Sukla):
'Shukla' is another author attributed to the research, signifying their contribution to the study. Recognizing individual researchers is essential for academic integrity, allowing readers to trace specific insights or methodologies associated with each author's area of expertise or oversight in the project.
9) Water:
'Water' is essential for life and, in this context, serves as a solvent or vehicle for administering the aqueous extract of Moringa oleifera to the study subjects. The presence and quality of water are critical for animal health and reliable biochemical measurements in experimental studies.
10) Diet:
'Diet' refers to the nutritional regimen of the rats used in the study. A proper diet ensures the health and vitality of the study subjects, influencing the outcomes of experiments on biochemical constituents in the uterus. The specified diet would provide necessary nutrients for maintaining normal physiological functions.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Uterine changes in rats: effect of Moringa oleifera extract.鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Control group, Experimental group, Aqueous extract, Alkaline phosphatase, Total protein, Moringa oleifera Lam, Glycogen content, Acid phosphatase, Biochemical constituents, Hormonal interactions.