Effect of nimbidin on gastric acid secretion
Journal name: Ancient Science of Life
Original article title: Effect of nimbidin on gastric acid secretion
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
N. R. Pillai, G. Santhakumari
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Effect of nimbidin on gastric acid secretion
Year: 1985
Copyright (license): CC BY-NC-SA
Download the PDF file of the original publication
Summary of article contents:
Introduction
Nimbidin, a bitter compound derived from the seeds of Azadirachta indica (neem), has been studied for its potential antiulcer properties and various pharmacological effects. This research aimed to explore nimbidin's influence on gastric acid secretion in different animal models, specifically focusing on its anti-secretory activity. The experiments were conducted using pylorus-ligated rats and cats, employing different doses of nimbidin and comparing its effects to those of the established H2-receptor antagonist, cimetidine.
Anti-Secretory Activity of Nimbidin
The findings revealed that nimbidin significantly decreased gastric secretory volume in pylorus-ligated rats without establishing a clear dose-response relationship. At a dose of 40 mg/kg, there was a notable reduction (p < 0.01) in gastric secretion; however, this was not accompanied by significant alterations in acidity, peptic activity, or mucin content. Furthermore, nimbidin did not prevent acid back-diffusion during treatment with acetylsalicylic acid (ASA). In stomach-lumen perfused rats, nimbidin demonstrated a partial suppression of both basal acid secretion and histamine- or carbachol-stimulated acid output. These results suggest that the anti-secretory action of nimbidin may possess similarities to H2-receptor antagonists, indicating a potential mechanism by which it exerts its antiulcer effects.
Conclusion
The research concluded that nimbidin exhibits significant anti-secretory activity, which could be attributed to a mechanism resembling H2-receptor antagonism, along with possible weak anti-cholinergic and ganglion-blocking properties. Although its efficacy in completely blocking gastric acid secretion elicited by histamine was limited, consistent suppression of peptic activity was observed over chronic administration. These properties suggest that nimbidin could serve as a viable therapeutic agent for managing gastric ulceration through its unique pharmacological effects. The study underscores the necessity for further investigations to evaluate nimbidin's potential in clinical settings.
FAQ section (important questions/answers):
What is Nimbidin and what plant does it come from?
Nimbidin is a crude bitter compound derived from the neem tree, scientifically known as Azadirachta indica. It has been studied for its various pharmacological effects, particularly its potential antiulcer properties.
What effects did Nimbidin have on gastric acid secretion in studies?
Nimbidin significantly reduced gastric secretory volume in animal models. While it decreased gastric secretion at specific doses, it did not significantly lower acidity or peptic activity in the gastric fluid.
How was the anti-secretory activity of Nimbidin tested?
The anti-secretory activity was evaluated using pylorus-ligated rats and stomach-lumen perfused rats. Nimbidin was administered orally or intravenously, and its impact on gastric acid secretion was measured over time.
What similarities does Nimbidin exhibit compared to H2-receptor antagonists?
Nimbidin showed an anti-secretory effect similar to H2-receptor antagonists, suppressing acid secretion stimulated by histamine and carbachol, indicating its potential as an antiulcer agent through H2-receptor antagonism.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for âEffect of nimbidin on gastric acid secretionâ�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'Drug' is relevant as it refers to nimbidin, the experimental compound isolated from Azadirachta indica (neem), which is being studied for its pharmacological effects, specifically its anti-secretory activity on gastric acid secretion in various animal models. Understanding the drug's efficacy is crucial for potential therapeutic use.
2) Activity:
Here, 'Activity' pertains to the pharmacological effects exhibited by nimbidin, specifically its action on gastric acid secretion. The researchers aim to determine nimbidin's effectiveness in reducing gastric secretions, akin to established drugs like H2-receptor antagonists, contributing to its medicinal evaluation.
3) Water:
'Water' plays a crucial role in the experimental methodology, especially in the preparation of solutions and as a physiological medium for the animals. Additionally, the significance of fasting the animals with water ad libitum prior to experimentation highlights its influence on physiological responses during testing.
4) Azadirachta indica:
This is the scientific name for the neem tree, from which nimbidin is derived. Its relevance lies in its traditional medicinal use and the compound's antiulcer potential, which drives research into its pharmacological properties and therapeutic applications in treating gastric conditions.
5) Pharmacological:
'Pharmacological' relates to the study of the effects of nimbidin on biological systems. It encompasses the investigation of nimbidinâs mechanisms and its actions on gastric acid secretion, illustrating the drug's potential role in therapeutics and underscoring the need for pharmacological evaluation.
6) Bitter:
The term 'Bitter' characterizes the taste profile of nimbidin, which is significant in traditional medicine practices as taste often correlates with certain pharmacological properties. In this context, the bitter principle indicates potential therapeutic efficacy in aiding digestion and gastrointestinal health.
7) Neem:
Referring to the neem tree, 'Neem' is pivotal as it is the source of nimbidin. Its historical role in traditional medicine for multiple ailments stimulates interest in its extracts' pharmacological activity, providing a foundation for investigating its biochemical properties and therapeutic possibilities.
8) Pharmacology:
'Pharmacology' is the scientific study of drugs and their actions in the body. This field underpins the research being conducted into nimbidin, focusing on understanding its mechanism of action, efficacy, and potential clinical applications as an antiulcer agent.
9) Discussion:
'Discussion' is a critical academic section where researchers analyze their findings. It connects the experimental results with existing literature, interpreting the implications of nimbidin's anti-secretory activity and its pharmacological relevance, guiding future research directions and therapeutic insights.
10) Ayurveda (Äyurveda, Ayus-veda):
'Ayurveda' refers to the ancient Indian system of medicine that emphasizes natural remedies and holistic health. The investigation into nimbidin ties into Ayurvedic practices that utilize neem for various ailments, illuminating the intersection of traditional knowledge and modern scientific inquiry.
11) Science (Scientific):
'Science' encompasses the systematic study of the natural world, which in this context refers to the scientific investigations performed to understand nimbidin's effects. Such research contributes to expanding knowledge in medicinal chemistry and pharmacotherapy, bridging traditional uses with biochemical analysis.
12) Siddha (SiddhÄ):
'Siddha' denotes a traditional system of medicine predominant in South India, sharing similarities with Ayurveda. This term highlights the cultural and historical context of nimbidin's use, enriching the narrative surrounding its therapeutic potential and emphasizing the significance of traditional medicine in contemporary scientific research.
13) Ulcer:
'Ulcer' refers to a condition characterized by the rupture of the protective lining of the gastrointestinal tract, leading to acid erosion. The study's relevance lies in exploring how nimbidin can mitigate gastric acid secretion, offering a potential therapeutic strategy for managing ulcers.
Other Science Concepts:
Discover the significance of concepts within the article: â�Effect of nimbidin on gastric acid secretionâ�. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Rat model, Vehicle control, Total acidity, Biochemical estimation, Gastric acid secretion, Dose level, H2 receptor antagonist, Pepsin concentration, Pylorus-ligated rats, Experiment methodology.