Significance of Vehicle control
Vehicle control refers to various experimental setups where a control group receives a substance that is neutral or inactive, such as a placebo or an inert solution, in order to compare the effects against a test drug or treatment. This includes groups given honey, distilled water, or 10% alcohol, among others. By utilizing a vehicle control, researchers can assess the effectiveness of active treatments by establishing a baseline for comparison, ensuring that the observed effects are due to the drug itself rather than other factors.
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Vehicle control in scientific sources
Vehicle control refers to a group in experimental studies that receives an inert substance, such as a placebo or neutral treatment, to assess the effects of test drugs by providing a comparison baseline.
From: World Journal of Pharmaceutical Research
(1) A group in an experiment that does not receive the experimental treatment, used as a baseline for comparison.[1] (2) Group within the experiment that received distilled water as a control treatment to compare against standard and test drugs.[2] (3) A reference substance, such as sterile triple distilled water, used to assess the effectiveness of a treatment.[3] (4) A group treated with a vehicle solution without the active substance to evaluate the effects of MPTP.[4] (5) A group used as a baseline in studies, which did not receive any treatment or intervention.[5]
From: AYU (Journal of Research in Ayurveda)
(1) A control group in the study receiving a placebo to compare the effects of the drug on experimental animals.[6] (2) A control group in experimental studies that receives a neutral substance (like honey) instead of the test drug to evaluate its effects.[7] (3) A group in an experiment that receives a placebo or inactive treatment to compare against the effects of the active treatment.[8] (4) A control group in the experiment that receives a substance, other than the test drug, to compare against the effects of test formulations.[9]
From: Ancient Science of Life
(1) A group in the experimental setup that received a placebo (10% alcohol), used to compare the effects of nimbidin treatment.[10]
From: Journal of Ayurveda and Integrative Medicine
(1) A group in the study that receives a placebo treatment, allowing researchers to compare the effects of Panchatikta Ghrita with that of a non-active substance.[11]