Significance of Histone modification
Histone modification refers to the chemical alteration of histone proteins that DNA wraps around, which significantly influences gene accessibility and expression. These modifications can affect chromatin structure and DNA compaction, thereby regulating the transcription of genes. Notably, processes like acetylation of specific lysine residues play a crucial role in enhancing or restricting DNA's accessibility for transcription, ultimately impacting overall gene expression. Through various chemical changes, histone modification serves as a vital mechanism in gene regulation.
Synonyms: Epigenetic modification, Histone acetylation, Histone methylation, Epigenetic regulation, Gene expression modulation, Chromatin remodeling
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The concept of Histone modification in scientific sources
Histone modification involves alterations to the proteins encasing DNA, impacting gene accessibility and, consequently, influencing gene expression. This process is crucial for regulating cellular functions and responding to environmental changes.
From: The Malaysian Journal of Medical Sciences
(1) Post-translational modifications of histone proteins that affect gene expression and are linked to ageing through their influence on chromatin structure.[1]