Significance of Epigenetic modification
Epigenetic modification refers to changes in gene expression that occur without altering the DNA sequence, primarily influenced by environmental factors such as diet and nutritional status. These modifications can involve processes like DNA methylation and histone modification. They play a crucial role in health outcomes, particularly during critical periods like pregnancy, and can affect responses to treatments and the development of disorders, including cancer. Additionally, epigenetic changes can be reversible and inherited by daughter cells, offering potential therapeutic avenues.
Synonyms: Epigenetic alteration, Epigenetic change, Epigenetic regulation, Genetic modification, Dna methylation, Histone modification, Chromatin remodeling, Gene silencing
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The concept of Epigenetic modification in scientific sources
Epigenetic modification involves changes to DNA that influence gene expression without altering the actual DNA sequence, playing a significant role in processes such as cancer development, according to regional sources.
From: The Malaysian Journal of Medical Sciences
(1) This refers to changes in gene expression that do not involve alterations to the DNA sequence itself, such as DNA-methylation.[1] (2) These modifications can be reversed by removing the epimarks or tags which causes behavioral changes in individuals, based on environmental experiences.[2]