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Study of Hepatitis E in Pregnant Women at Eldmazin Hospital, Sudan.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Cross- sectional study of hepatitis e virus among pregnant women attending eldmazin hospital obstetrics and gynecology, blue nile state, sudan
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Fatin Elzebair Siddig, Sid M. A., Salah E. I., Hassan Mohamed Eissa and Abdelrahim M. Abdelrazig


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Cross- sectional study of hepatitis e virus among pregnant women attending eldmazin hospital obstetrics and gynecology, blue nile state, sudan

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20232-26770

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

This study investigates the seroprevalence of Hepatitis E Virus (HEV) among pregnant women attending Eldamazain Hospital in Blue Nile State, Sudan, conducted from September to December 2016. HEV, primarily affecting developing countries, is a leading cause of acute viral hepatitis (AVH). The research aims to detect the presence of IgM and IgG antibodies against HEV, thereby assessing the infection rates and risk factors associated with HEV among this vulnerable population.

Prevalence of HEV Infection

The study found a total of 196 pregnant women sampled, with results indicating that 7.1% tested positive for IgM and 6.1% for IgG. The overall infection rates were notably lower compared to other regions, such as Darfur, Egypt, and India. The variance in HEV prevalence could stem from different environmental, socio-economic factors, and the small sample size used in this study. The significant finding reveals that the majority of those affected were in their second and third trimesters, underscoring the heightened risk during these stages of pregnancy.

Age and Educational Status as Risk Factors

The analysis highlighted the correlation between age and HEV infection rates, with a higher prevalence observed among women aged 18 to 37 years. Additionally, the study noted that illiteracy and lower educational levels were associated with a greater risk of HEV infection. Pregnant women from less educated backgrounds exhibited a higher likelihood of HEV positivity, implying that insufficient health education and poor hygiene practices might contribute to increased vulnerability among these groups.

Hygiene Practices and Water Sources

Hygiene practices significantly influenced the prevalence of HEV infections. Despite a high percentage of participants washing hands after defecation and before meals, the data revealed that those who sourced drinking water from wells had a higher rate of HEV antibodies. This suggests that contaminated water sources may serve as a vector for HEV transmission. Additional analysis indicated a risk correlation with practices surrounding food hygiene, reinforcing the need for educational interventions focused on safe hygiene practices.

Conclusion

In conclusion, the study demonstrates a significant presence of Hepatitis E antibodies in pregnant women in Blue Nile State, suggesting potential public health implications. To mitigate the risk of HEV infection, it is essential to raise awareness through education programs targeted at pregnant women. Enhanced testing for Hepatitis E in cases of acute hepatitis is recommended, and routine screening using immunological tests should be integrated into prenatal care to ensure better health outcomes for mothers and their infants.

FAQ section (important questions/answers):

What was the objective of the hepatitis E virus study?

The study aimed to detect IgM and IgG antibodies of hepatitis E virus in pregnant women using ICT and ELISA in Eldamazin, Blue Nile State, Sudan.

How many pregnant women participated in the study?

A total of 196 pregnant women attending Eldamazin Obstetrics and Gynecology Teaching Hospital participated in the study conducted from September to December 2016.

What were the main findings regarding hepatitis E virus prevalence?

The study found that 14 (7.1%) were positive for ICT (IgM) & ELISA IgG, while 12 (6.1%) were positive for ELISA IgM, indicating low prevalence among the pregnant women examined.

What was the method used for analyzing serum samples?

Serum samples were analyzed using Immuno chromatographic Test (ICT) and enzyme-linked immune-sorbent assay (ELISA) to detect HEV antibodies.

What risk factors were associated with HEV infection in the study?

The study revealed associations between HEV infection and factors like age, pregnancy trimester, educational level, and water source for drinking, with higher rates in uneducated women and those using well water.

What recommendations were made based on the study findings?

The study recommended educational programs for pregnant women to improve hygiene, enhance hepatitis E testing in acute cases, and implement screening programs as part of routine examinations.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study of Hepatitis E in Pregnant Women at Eldmazin Hospital, Sudan.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The study is a descriptive cross-sectional examination designed to evaluate hepatitis E virus seroprevalence among pregnant women at a specific hospital. It aims to provide insights into health trends and risk factors, ultimately contributing to better public health interventions and strategies in the region.

2) Pregnant:
Pregnant women are the focus of the study as they are considered a high-risk group for viral infections, including hepatitis E. Pregnancy can alter immune responses, making these women more susceptible to infections. Understanding HEV prevalence in this demographic is crucial for maternal and fetal health.

3) Water:
The water aspect in the study focuses on its role as a transmission medium for hepatitis E. The quality and source of drinking water among pregnant women are assessed to identify potential links to HEV infection, underscoring the need for improved water sanitation and quality controls.

4) Cutan:
Sudan is the geographical context of the study, specifically focusing on the Blue Nile State. The country's healthcare infrastructure, prevalence of infectious diseases, and socio-economic conditions play a vital role in influencing the study's outcomes and the general health of its population, particularly vulnerable groups like pregnant women.

5) Line:
Line refers to the lines of tests or results in the immunological assays utilized in the study, such as the ICT and ELISA. These tests display control and test lines, which indicate whether the IgM antibodies against HEV are present, making it essential for interpreting the test results accurately.

6) Viru:
Viru likely pertains to the term 'virus,' specifically the hepatitis E virus in this context. Understanding the characteristics of HEV, including its transmission mode, symptoms, and impact on particular populations, is crucial for developing effective prevention and treatment strategies within the healthcare system.

7) Education:
Education plays a vital role in raising awareness about hygiene practices and preventive measures against hepatitis E. The study highlights the educational background of participants and correlates it with infection rates, underlining the need to implement educational programs to reduce transmission risks in vulnerable populations.

8) Hand:
Hand hygiene is emphasized as a fundamental practice that can prevent infections, including hepatitis E. The study evaluates participants' handwashing habits and correlates them with HEV infection rates, illustrating the importance of good hygiene in controlling viral diseases, especially in high-risk populations.

9) Container:
Container refers to the sterile containers used for blood sample collection in the study. Proper sample collection and handling are critical in ensuring the accuracy of the laboratory tests conducted, which impacts the reliability of the findings regarding hepatitis E prevalence among the surveyed population.

10) Teaching:
Teaching relates to the educational aspects surrounding the study, particularly regarding health education aimed at pregnant women. Effective teaching strategies can inform these women about the risks of hepatitis E, hygiene practices, and the importance of seeking timely medical advice to protect both their health and that of their unborn children.

11) Science (Scientific):
Science denotes the structured approach used to conduct the study, encompassing the methodologies applied in microbiological testing, data analysis, and interpretation of results. The application of scientific principles is essential for achieving reliable and valid outcomes that inform public health decision-making.

12) Gold (Golden):
Gold here likely refers to the 'gold standard' methods used for testing, particularly the ELISA for confirming HEV infections. Utilizing a gold standard approach ensures the reliability of results, allowing healthcare professionals to effectively diagnose and manage hepatitis E infections in the studied population.

13) Attending:
Attending relates to the pregnant women who seek medical care at the Eldamazin Obstetrics and Gynecology Teaching Hospital. Their participation is crucial for the study in understanding the prevalence of hepatitis E, as it highlights the intersection of healthcare access and infectious disease exposure in this population.

14) Medicine:
Medicine refers to the field concerned with diagnosing, treating, and preventing illnesses. In the context of the study, understanding HEV infection among pregnant women is critical for informing medical interventions and improving maternal health practices in regions affected by hepatitis.

15) Hygiene (Hygienic):
Hygiene practices, including handwashing and food safety, are paramount in preventing HEV transmission. The study investigates the correlation between participants' hygiene behaviors and infection rates, emphasizing the need for effective education and public health interventions to improve hygiene practices among vulnerable populations.

16) Epidemic:
Epidemic refers to the rapid spread of an infectious disease within a population. The study contributes to understanding the epidemiology of hepatitis E in pregnant women in Sudan, identifying patterns of infection that may signal the need for public health interventions to control potential outbreaks.

17) Blood:
Blood is the biological sample analyzed to detect the presence of HEV antibodies among pregnant women in the study. Proper handling and testing of blood samples are essential for accurate diagnosis and understanding the seroprevalence of hepatitis E within the population.

18) New Delhi:
New Delhi represents a historical reference point in hepatitis E's epidemiology, as it was the site of one of the first documented outbreaks of water-borne hepatitis. Such cases provide critical insights into the virus's behavior and transmission dynamics, informing studies on current outbreaks in similar regions.

19) Malnutrition:
Malnutrition can increase susceptibility to infections, including hepatitis E. It may reflect underlying issues in public health system effectiveness, particularly in low-resource settings like Sudan. The study highlights the connection between malnutrition, immune responses, and the prevalence of infectious diseases among pregnant women.

20) Developing:
Developing countries are often more vulnerable to infectious diseases due to poorer healthcare infrastructure, inadequate sanitation, and limited resources. The study is situated in Sudan, a developing country context, emphasizing the relevance of understanding HEV prevalence to inform targeted public health strategies to improve maternal health.

21) Activity:
Activity refers to the collective economic practices that characterize the Blue Nile State, such as agriculture and pastoralism. These activities can influence health outcomes by affecting social determinants, including access to clean water and healthcare facilities, which are critical factors in managing infectious diseases.

22) Disease:
In this context, disease refers specifically to hepatitis E, which poses significant health risks to pregnant women. Understanding the incidence, transmission, and impact of this disease among vulnerable populations is essential for developing public health policies and intervention strategies.

23) Donkey:
Donkey can be seen as a component of household animal ownership. The study suggests a correlation between keeping donkeys and the prevalence of HEV antibodies among pregnant women, possibly implicating zoonotic transmission routes and highlighting the need for better animal health awareness.

24) Animal:
Animal refers to livestock or pets that may interact with humans, potentially posing health risks. In the context of the study, understanding the relationship between animal husbandry practices and hepatitis E infection can provide insight into zoonotic transmission pathways that affect public health.

25) Patra:
Patra is likely mentioned in reference to a study conducted by researchers that provided comparative results related to hepatitis E infection rates among pregnant women. Such studies contribute to a broader understanding of epidemiological patterns and help in formulating public health recommendations.

26) Delhi:
Delhi, being a significant urban center in India, often acts as a reference point for epidemiological studies, especially concerning infectious diseases like hepatitis E. Its past outbreaks provide valuable information for current studies and inform proactive health measures in similar environments.

27) India:
India represents a context where hepatitis E has been studied extensively, with high prevalence rates reported among various populations. Insights from Indian studies on HEV can inform approaches used in other countries, including Sudan, regarding the management of similar health challenges.

28) Ghana:
Ghana is mentioned as a comparative reference point to place prevalence rates in the context of hepatitis E studies among pregnant women. Understanding findings from Ghana can help researchers and policymakers in Sudan gauge the severity of HEV infections and implement effective healthcare strategies.

29) Table:
Table likely refers to the structured presentation of data collected during the study. It serves to effectively communicate findings, highlight significant correlations, and make the results accessible for analysis, aiding in the interpretation and understanding of the research objectives.

30) Death:
Death from hepatitis E, though relatively low in percentage, is a critical concern, particularly for vulnerable populations such as pregnant women. The study aims to understand and mitigate the risks associated with HEV to improve maternal and fetal health outcomes and reduce mortality rates.

31) House:
House typically refers to the home environment where participants live. Understanding household conditions, including sanitation and animal ownership, can provide insights into risk factors for HEV exposure, influencing public health measures aimed at improving infection prevention strategies.

32) Egypt:
Egypt serves as another comparative context regarding hepatitis E prevalence, providing insights into the regional variations and health implications of the virus. Studying HEV infection rates in Egypt can help guide interventions tailored to lower prevalence in similar settings, like Sudan.

33) Pur:
Poor conditions often correlate with higher rates of infection, as they indicate limited access to healthcare, sanitation, and education. The study's focus on pregnant women from various educational and economic backgrounds underlines the importance of addressing socioeconomic disparities in health interventions.

Other Science Concepts:

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Discover the significance of concepts within the article: �Study of Hepatitis E in Pregnant Women at Eldmazin Hospital, Sudan.�. Further sources in the context of Science might help you critically compare this page with similair documents:

Washing hands, Jaundice, Educational level, Statistical analysis, Age-group, Sample size, Study population, Cross-sectional study, Prevalence rate, First trimester, Second trimester, Third trimester, Risk factor, Molecular tools, Serum sample, Statistical package for social science, Materials and method, Hepatitis E virus, IgG and IgM, Education program.

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