Evaluation of Tiryaqe wabai as an immunostimulator in the elderly.
Journal name: Ancient Science of Life
Original article title: Evaluation of a Unani polyherbal formulation (Tiryaqe wabai) as an immunostimulator in elderly persons
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Zar Nigar, Malik Itrat
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Evaluation of a Unani polyherbal formulation (Tiryaqe wabai) as an immunostimulator in elderly persons
Year: 2013
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The aging process leads to significant changes in the immune system, particularly resulting in a dysregulation of immune response and heightened susceptibility to infections in elderly individuals. This study evaluates the immune-stimulating effects of a Unani polyherbal formulation known as Tiryaq wabai, traditionally utilized for the prevention of epidemic diseases. Despite its historical use, this formulation had not previously been scientifically explored for its immunostimulatory properties, prompting the need for this research.
Immunostimulation by Tiryaq wabai
In a randomized placebo-controlled trial conducted at the National Institute of Unani Medicine in Bengaluru, 30 immunocompromised elderly participants were assigned to receive either Tiryaq wabai (500 mg thrice weekly for 45 days) or placebo. The formulation demonstrated a statistically significant increase in total leucocyte count, lymphocyte percentage, and absolute lymphocyte count, alongside a notable rise in CD4 T-cell counts. The results indicate that Tiryaq wabai effectively stimulates the immune system, with no major adverse effects reported during the study, underscoring its potential as a therapeutic agent for immunocompromised elderly patients.
Conclusion
The findings of this study support the use of Tiryaq wabai as an effective immunostimulator for elderly individuals experiencing immune senescence. Given the encouraging outcomes, this Unani formulation may offer therapeutic benefits for conditions requiring immune enhancement and could be a valuable addition to conventional treatment modalities. Further research is warranted to explore its applications in immunodeficiency diseases and as an adjuvant in vaccine therapies.
FAQ section (important questions/answers):
What is the main aim of the study on Tiryaq wabai?
The study aimed to evaluate the immune-stimulating effect of the Unani polyherbal formulation Tiryaq wabai in elderly individuals, particularly in those with immunocompromised conditions.
How was the trial designed for testing Tiryaq wabai?
A randomized placebo-controlled trial included 30 immunocompromised elderly participants, divided into a test group receiving 500 mg of Tiryaq wabai and a control group receiving a placebo, for 45 days.
What were the significant findings of the Tiryaq wabai study?
Results showed significant increases in total leucocyte count, lymphocyte percentage, absolute lymphocyte count, and CD4 count in the test group, suggesting positive immune-stimulating activity from Tiryaq wabai.
Was Tiryaq wabai found safe for participants during the study?
Yes, no major adverse effects were observed throughout the study, indicating that Tiryaq wabai is safe for use among the elderly with immunocompromised conditions.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of Tiryaqe wabai as an immunostimulator in the elderly.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Medicine:
Medicine is the field focused on the diagnosis, treatment, and prevention of diseases. In this context, Unani medicine emphasizes holistic approaches, integrating various herbal formulations to boost immunity, especially in the elderly whose immune system is compromised. This study evaluates a specific Unani drug, supporting its therapeutic relevance.
2) Epidemic:
Epidemic refers to a widespread occurrence of an infectious disease within a community or region. The study highlights the use of the Unani formulation, Tiryaq wabai, historically applied during epidemics for preventive measures, thus exploring its potential role in enhancing immunity in susceptible elderly populations.
3) Drug:
A drug is a chemical substance used for medical purposes, including diagnosis, cure, treatment, or prevention of disease. The Unani formulation Tiryaq wabai is assessed in this study for its immunostimulating effects, indicating herbal drugs' relevance in managing health, particularly in immunocompromised individuals.
4) Activity:
Activity pertains to the actions or effects of a substance within a biological system. In this study, the activity of Tiryaq wabai as an immune stimulator showcases the importance of evaluating herbal formulations for their physiological responses, aiming to combatimmune deterioration in aging individuals.
5) Blood:
Blood is vital for transporting oxygen, nutrients, and immune cells throughout the body. The study measures various blood parameters, including total leukocyte count and lymphocyte percentage, to assess the immunostimulating effect of Tiryaq wabai, highlighting the interconnectedness of blood health and immune system efficacy.
6) Inflammation:
Inflammation is the body’s natural response to injury or infection and can affect immune function. The study underscores the significance of modulating inflammation via herbal medications such as Tiryaq wabai to restore immune balance in elderly patients, potentially reducing the risk of infection.
7) Antibiotic (Antibacterial):
Antibiotics are drugs that fight bacterial infections. The study discusses how Tiryaq wabai may serve as an adjunct therapy in immunocompromised elderly persons, suggesting that herbal formulations could enhance the effectiveness of antibiotics by stimulating the immune system, thus promoting better health outcomes.
8) Substance:
A substance is a form of matter that has a specific chemical composition and characteristics. The study focuses on the testing of a herbal substance, Tiryaq wabai, to evaluate its immunostimulating properties, reinforcing the exploration of natural substances in modern medical science.
9) Crocus sativus:
Crocus sativus, commonly known as saffron, is a flowering plant whose stigmas are used as a spice and in traditional medicine. The study cites its inclusion in Tiryaq wabai for its potential health benefits, including its role in immune modulation, reflecting the importance of herbal ingredients in therapeutic formulations.
10) Pharmacological:
Pharmacological refers to the study of drug action and how substances affect biological systems. This study provides insights into the pharmacological effects of Tiryaq wabai, emphasizing the necessity of scientific understanding of herbal formulations in enhancing immune functions, particularly for aging populations.
11) Accumulation (Accumulating, Accumulate):
Accumulated implies the gradual gathering or collection over time. In the context of this study, the accumulated knowledge from traditional practices supports the investigation of Tiryaq wabai, merging historical wisdom with contemporary research to validate its use in boosting immunity in the elderly.
12) Discussion:
Discussion revolves around explicating findings and their implications. This section of the study addresses the outcomes of the trial, detailing how Tiryaq wabai affects immune parameters, fostering an understanding of its potential use in managing immune deficiencies among older adults.
13) Science (Scientific):
Science is the systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. In this study, the application of scientific principles to evaluate the immunostimulating properties of Tiryaq wabai demonstrates the integration of traditional medicine and modern scientific inquiry.
14) Vomiting:
Vomiting is the involuntary expulsion of stomach contents, often a side effect of various medications. This study takes into account patient tolerability, emphasizing that no major adverse effects, including vomiting, were observed with Tiryaq wabai, bolstering its safety as a treatment option for vulnerable populations.
15) Cancer:
Cancer is a disease characterized by uncontrolled cell division and can significantly impact immune responses. While the primary focus of the study is on immunostimulation, the implications of such herbal formulations may extend to support overall health in cancer patients by enhancing their immunity.
16) Nausea:
Nausea is a common symptom involving discomfort in the stomach, often accompanied by the urge to vomit. This study considers the tolerability of Tiryaq wabai, explicitly noting the absence of nausea as a side effect, highlighting the importance of patient comfort in herbal treatment regimens.
17) Reason:
Reason refers to the rationale behind a belief or action. In the context of this study, the reason for selecting Tiryaq wabai for immune enhancement lies in Unani medicine’s historical application during epidemics, seeking to scientifically validate such traditional practices for modern healthcare.
18) Water:
Water is a critical component of biological systems, necessary for various physiological functions. Although not directly discussed in the study, the relevance of hydration in supporting overall health and the efficacy of drug delivery highlights the importance of water in any therapeutic regimen.
19) Post:
Post signifies after or following a particular event. The study measures post-treatment immunological changes to ascertain the efficacy of Tiryaq wabai, delineating its impact after the administration period, thus informing about its sustained effects in enhancing the immune system.
Other Science Concepts:
Discover the significance of concepts within the article: �Evaluation of Tiryaqe wabai as an immunostimulator in the elderly.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Antioxidant activity, Immune response, CD4 count, Cell-mediated immunity, Bioactive compound, Unani medicine, Epidemic disease, LYMPHOCYTE PERCENTAGE, Tiryaq Wabai, Randomized placebo-controlled trial, Absolute lymphocyte count (ALC), Oxidant.