Effect of Cucumis trigonus extract on antioxidants in urolithiasis rats
Journal name: Ancient Science of Life
Original article title: Effect of ethanolic fruit extract of Cucumis trigonus Roxb. on antioxidants and lipid peroxidation in urolithiasis induced wistar albino rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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A. Balakrishnan, R Kokilavani, K. Gurusamy, K. S. Ananta Teepa, M. Sathya
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Effect of ethanolic fruit extract of Cucumis trigonus Roxb. on antioxidants and lipid peroxidation in urolithiasis induced wistar albino rats
Year: 2011
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Urolithiasis, the formation of kidney stones, is a common health issue characterized by the crystallization of minerals, particularly calcium oxalate, in the urinary tract. The oxidative stress generated during the development of these stones leads to significant damage to the body's antioxidant defense system. Cucumis trigonus Roxb., a plant used in traditional medicine, has been investigated for its potential therapeutic properties against such oxidative stress. The study explored the effects of ethanolic fruit extract from Cucumis trigonus on the antioxidant levels and lipid peroxidation in Wistar albino rats induced with urolithiasis using ethylene glycol.
Antioxidant Recovery through Cucumis trigonus Extract
The major finding of this study was the extract's ability to restore the levels of both enzymatic and non-enzymatic antioxidants in the liver and kidney tissues of the rats. Specifically, the ethanolic extract of Cucumis trigonus significantly improved the activities of key antioxidant enzymes such as Superoxide Dismutase (SOD), Catalase (CAT), and Glutathione Peroxidase (GPx), which are crucial for cellular protection against oxidative damage. Furthermore, the extract also reduced levels of malondialdehyde, a marker for lipid peroxidation, indicating a decrease in oxidative damage. These results imply that Cucumis trigonus may combat oxidative stress associated with urolithiasis by enhancing the antioxidant defense mechanisms within the body.
Conclusion
The study presents promising evidence that the ethanolic fruit extract of Cucumis trigonus Roxb. has a protective effect against oxidative damage in the context of urolithiasis. By normalizing the levels of antioxidants and reducing lipid peroxidation, the extract demonstrates potential as a natural therapeutic agent. This aligns with the broader field of research exploring the efficacy of medicinal plants in managing diseases linked to oxidative stress, suggesting that Cucumis trigonus may serve as a valuable addition to alternative treatments for urolithiasis and related conditions. Further research on the pharmacological properties and mechanisms of action of this extract may lead to its incorporation into clinical therapies.
FAQ section (important questions/answers):
What was the main objective of the study on Cucumis trigonus?
The study aimed to evaluate the effects of ethanolic fruit extract of Cucumis trigonus on antioxidants and lipid peroxidation in Wistar albino rats induced with urolithiasis.
How was urolithiasis induced in the rats?
Urolithiasis was induced in Wistar albino rats using ethylene glycol, which led to the formation of calcium stones and damage to the antioxidant system.
What were the key findings regarding antioxidant levels?
The ethanolic extract from Cucumis trigonus significantly normalized the levels of enzymatic and non-enzymatic antioxidants in the liver and kidney of rats with urolithiasis.
What impact did the fruit extract have on lipid peroxidation?
The study showed that treatment with Cucumis trigonus extract resulted in a significant reduction in lipid peroxidation levels in both the liver and kidney of the affected rats.
Other Science Concepts:
Discover the significance of concepts within the article: �Effect of Cucumis trigonus extract on antioxidants in urolithiasis rats�. Further sources in the context of Science might help you critically compare this page with similair documents:
Medicinal plant, Therapeutic agent, Traditional medicine, Lipid peroxidation, Oxidative damage, Animal studies, Glutathione peroxidase, Superoxide dismutase, Catalase, Ethanol extract, Malondialdehyde, In vivo studies, Cucumis trigonus Roxb, Renal epithelial cells, Bioactive component, Calcium Stone, Antioxidant system, Open access article, Oxidant-antioxidant imbalance.