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Antidiabetic and antihypercholesterolemic effects of Hemidesmus root.

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Journal name: Ancient Science of Life
Original article title: Antidiabetic and antihypercholesterolemic effect of Hemidesmus indicus Linn.R. root in Alloxan induced diabetic rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

C. Sowmia, Dr. R. Kokilavani


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Antidiabetic and antihypercholesterolemic effect of Hemidesmus indicus Linn.R. root in Alloxan induced diabetic rats

Year: 2007

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

Diabetes mellitus is characterized by elevated blood glucose levels along with alterations in glucose and lipid metabolism. While the liver plays a crucial role in maintaining glucose and lipid levels, it is often adversely affected during diabetes. This study investigates the antidiabetic and antihyperlipidemic effects of Hemidesmus indicus Linn.R. root on alloxan-induced diabetic rats. Known for its various medicinal properties, the root of Hemidesmus indicus has been traditionally utilized in Ayurvedic medicine to treat conditions such as fever, diabetes, and other blood disorders.

Hypoglycemic and Hypolipidemic Effects of Hemidesmus indicus

The experimental outcomes demonstrated that the administration of Hemidesmus indicus root extract resulted in significant reductions in blood glucose and serum lipid levels in diabetic rats. Specifically, a notable decrease in cholesterol, triglycerides, free fatty acids, and phospholipids was observed, indicating the extract's potent antihyperlipidemic effects. Furthermore, blood glucose levels in diabetic rats significantly normalized following treatment. The extract's action may be attributed to either enhanced secretion of insulin from pancreatic cells or improved transportation of glucose to peripheral tissues, as seen by increased plasma insulin levels in treated rats. These findings suggest that Hemidesmus indicus could offer a potential therapeutic strategy for managing diabetes and its associated lipid abnormalities.

Conclusion

The study's conclusions indicate that Hemidesmus indicus Linn.R. root possesses significant antidiabetic and antihyperlipidemic properties. By decreasing both blood glucose and elevated serum lipid levels in alloxan-induced diabetic rats, the extract may represent a protective mechanism against complications such as atherosclerosis, which is often exacerbated by diabetes. The traditional use of Hemidesmus indicus in treating diabetes is supported by empirical evidence, highlighting the importance of integrating ethnobotanical approaches with modern scientific research to uncover effective therapeutic agents for diabetes management.

FAQ section (important questions/answers):

What are the effects of Hemidesmus indicus root on diabetes?

The study found that Hemidesmus indicus root significantly reduced blood glucose levels and exhibited antihyperlipidemic effects in alloxan-induced diabetic rats, suggesting its potential as a natural treatment for diabetes.

How was diabetes induced in the experimental rats?

Diabetes was induced in male Wister rats by injecting alloxan monohydrate at a dose of 150 mg/kg body weight, leading to hyperglycemia and glycosuria characteristic of diabetes.

What dosage of Hemidesmus indicus root extract was used in the study?

The study administered 40 mg of Hemidesmus indicus root extract per gram of body weight daily for four weeks to evaluate its antidiabetic and antihyperlipidemic effects.

What methods were used to analyze blood glucose and lipid levels?

Blood glucose was measured using the O-Toluidine method, while lipid levels were extracted and analyzed using established methods for cholesterol, triglycerides, free fatty acids, and phospholipids.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Antidiabetic and antihypercholesterolemic effects of Hemidesmus root.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Blood:
Blood is a crucial bodily fluid that serves multiple functions, including providing oxygen and nutrients to tissues and removing waste. In the context of diabetes, blood glucose levels are a critical parameter to monitor. The study examines how treatments affect blood chemistry, particularly in diabetic rats, emphasizing its importance in metabolic studies.

2) Sugar:
Sugar, specifically glucose, is a primary source of energy for the body, but its dysregulation is a hallmark of diabetes mellitus. The research focuses on how Hemidesmus indicus impacts blood sugar levels, showcasing its potential antidiabetic properties, which is vital for maintaining metabolic health in diabetics.

3) Science (Scientific):
Science encompasses systematic enterprise that builds and organizes knowledge through testable explanations and predictions about the universe. This study exemplifies scientific research by exploring a traditional remedy's applicability to modern medicinal challenges, thus bridging traditional knowledge and contemporary scientific methodologies in health care.

4) Activity:
Activity, in this context, refers to the biological actions and effects of compounds or extracts on metabolic functions. The study evaluates the antidiabetic and antihypercholesterolemic activities of Hemidesmus indicus, establishing how such activities can lead to therapeutic benefits in treating diabetes and related lipid disorders.

5) Drug:
A drug is a substance used to treat, cure, prevent, or diagnose a disease. In this study, glibenclamide, a known antidiabetic medication, serves as a comparison to assess the efficacy of Hemidesmus indicus as a potential herbal drug for managing diabetes and its complications through chemical interactions.

6) Pharmacological:
Pharmacological refers to the study of how drugs interact with biological systems. This research investigates the pharmacological effects of the Hemidesmus indicus extract on diabetic rats, analyzing its potential to modulate glucose and lipid metabolism, which is key to understanding its therapeutic potential.

7) Musha (Musa, Musā, Mūṣ�, Muṣ�, Musá):
Musa refers to a genus of herbaceous plants, including bananas and plantains, recognized for their medicinal properties. The document references Musa due to its recognized antihyperglycemic effects, paralleling the study's interest in natural compounds from plants that can support diabetes management and nutrient absorption.

8) Purification:
Purification in this study refers to extracting active compounds from Hemidesmus indicus for analysis. This process is crucial to isolate the bioactive constituents that exhibit therapeutic effects, ensuring that the research accurately represents the efficacy and safety of the extract concerning blood glucose and lipid levels.

9) Discussion:
Discussion is a section in scientific papers where results are interpreted, contextualized within existing literature, and implications are drawn. This study's discussion emerges from observed data to elucidate how Hemidesmus indicus influences metabolic conditions, emphasizing its potential role in treating diabetes compared to conventional drugs.

10) Knowledge:
Knowledge in scientific terms refers to the understanding developed from systematic research and experimentation. This study builds on existing herbal and pharmacological knowledge regarding diabetes treatments, contributing new insights about Hemidesmus indicus as a viable supplement to traditional diabetes therapies.

11) Toxicity:
Toxicity assessment is vital in pharmacological studies to ensure the safety of herbal treatments. The study evaluates the effects of Hemidesmus indicus while considering its toxicity, essential for determining the therapeutic index and potential side effects, thus ensuring safe application in diabetes management.

12) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. The study evaluates traditional medicine (Hemidesmus indicus) within a scientific framework, bridging herbal remedies with modern medical practices, thereby expanding the options available for diabetes treatment with a focus on holistic health.

13) Nannari (Nannāri, Naṉṉāri):
Nannari is the local name for Hemidesmus indicus and represents its cultural significance in traditional medicine, particularly in South India. Understanding its uses in local practices enhances the relevance of the study, demonstrating how traditional names and cultural knowledge can inform contemporary therapeutic research.

14) Sharman (Śarma, Sarmā, Sarma, Sharma, Śarman):
Sharma refers to a researcher whose studies contribute to understanding diabetes and its treatment methodologies. Mentioning notable authors like Sharma highlights the continuation of research and collaboration in the field, thus linking new findings about Hemidesmus indicus to the broader academic landscape of diabetes research.

15) Water:
Water is essential for life and serves as a solvent for many biological reactions. In this study, water reference might pertain to the aqueous extraction process of Hemidesmus indicus, underlining how solvents facilitate the extraction of bioactive compounds for therapeutic evaluation, crucial for dietary and medicinal applications.

16) Neem:
Neem is a tree renowned for its medicinal properties, often highlighted in studies on diabetes for its potential hypoglycemic effects. The reference to neem indicates the context of herbal remedies in diabetes studies, suggesting a trend toward exploring various plants with medicinal relevance and establishing a broader perspective on alternative therapies.

Other Science Concepts:

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Discover the significance of concepts within the article: �Antidiabetic and antihypercholesterolemic effects of Hemidesmus root.�. Further sources in the context of Science might help you critically compare this page with similair documents:

Hemidesmus indicus, Therapeutic application, Ayurvedic system of medicine, Diabetes mellitus, Statistical analysis, Serum cholesterol, Antidiabetic activity, Hyperglycemia, Lipid metabolism, Glucose metabolism, Alloxan-induced diabetes, Blood glucose level, Hypolipidemic agent, Plasma insulin, Experimental procedure, Intragastric tube, Diabetic rat.

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