Oxidative Stress Evaluation After Polyherbal Therapy in Cholelithiasis
Journal name: Ancient Science of Life
Original article title: Evaluation of Oxidative Stress Status Following Polyherbal Formulation Therapy In Patients of Cholelithiasis with Choledocholithiasis
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Pankaj Srivastava, M. Sahu, Shruti Khanna, Hari D. Khanna
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Evaluation of Oxidative Stress Status Following Polyherbal Formulation Therapy In Patients of Cholelithiasis with Choledocholithiasis
Year: 2005
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study evaluates the oxidative stress status in patients suffering from cholelithiasis with choledocholithiasis, particularly focusing on the malondialdehyde (MDA) levels in bile juice. Oxidative stress arises from free radicals, which can harm tissues, proteins, and fats within the body, contributing to various diseases. The research specifically examines the effect of a polyherbal formulation known as "Phaltrikadi Kwath" on this oxidative stress following cholecystectomy with choledochotomy and T-tube drainage. Phaltrikadi Kwath consists of eight medicinal plants that are traditionally recognized for their potential health benefits, including antioxidant properties.
Antioxidant Potential of Phaltrikadi Kwath
The study extensively measures lipid peroxidation levels represented by MDA in the bile samples of patients. Results show that surgical trauma increases oxidative stress, indicated by higher MDA levels immediately after the operation. However, following the administration of Phaltrikadi Kwath from the 3rd to the 10th post-operative day, there is a significant reduction in oxidative stress as seen from lowered MDA levels in bile. The significant difference in MDA levels between the treatment and control groups indicates the antioxidant potential of the polyherbal formulation, demonstrating its efficacy in mitigating oxidative stress and suggesting a role in the prevention of bile-related complications such as gallstone formation.
Conclusion
The findings suggest that oxidative stress plays a crucial role in the postoperative state of patients undergoing cholecystectomy due to gallstones. The polyherbal formulation, Phaltrikadi Kwath, demonstrates significant antioxidant activity, reducing lipid peroxidation and offering protective benefits to the biliary system post-surgery. This suggests that Phaltrikadi Kwath could potentially be utilized as a cost-effective therapeutic option to prevent not only oxidative stress but also the recurrence of gallstones in patients. Thus, further studies may be warranted to confirm its clinical efficacy and explore its integration into standard postoperative care protocols.
FAQ section (important questions/answers):
What is the focus of the study conducted on Phaltrikadi Kwath?
The study evaluates the oxidative stress status in patients with cholelithiasis and choledocholithiasis, specifically assessing the effects of the polyherbal formulation Phaltrikadi Kwath on malondialdehyde (MDA) levels in bile post-surgery.
What are the main components of the Phaltrikadi Kwath formulation?
Phaltrikadi Kwath consists of eight herbs: Haritaki, Vibhitaki, Amalaki, Guduchi, Kutki, Chirayita, Vasa, and Neem, known for their medicinal properties such as being cholagogue, immunomodulatory, and antioxidant.
How was lipid peroxidation measured in this study?
Lipid peroxidation levels were assessed by measuring malondialdehyde (MDA) in bile samples using spectrophotometry, with samples taken pre-operatively and on the 3rd and 10th postoperative days.
What were the findings regarding the antioxidant potential of Phaltrikadi Kwath?
The study found that Phaltrikadi Kwath significantly decreased oxidative stress levels in bile, indicating its antioxidant potential and suggesting its preventive use against gallstone recurrence.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淥xidative Stress Evaluation After Polyherbal Therapy in Cholelithiasis鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The keyword 'Drug' denotes a substance used in the medical field for therapeutic purposes. In this study, 'Phaltrikadi Kwath' is examined as a polyherbal formulation with several pharmacological properties, highlighting its role in managing conditions like cholelithiasis and choledocholithiasis. Its composition and effects are evaluated to assess efficacy.
2) Post:
'Post' refers to the period following a surgical procedure or treatment. In the context of this study, it particularly pertains to the post-operative days (specifically from the 3rd to the 10th day) during which the effects of the herbal formulation were monitored and evaluated for oxidative stress levels in patients.
3) Science (Scientific):
'Science' implies a systematic study of the natural world through observation and experimentation. In this study, it underlines the scientific approach to understanding oxidative stress and the efficacy of herbal treatments, emphasizing rigorous methodologies and evaluations that allow for evidence-based conclusions in the medical field.
4) Kamala (Kamal膩, K膩mal膩, K膩m膩la, Kama-la):
'Kamala' relates to a traditional term in Ayurveda that signifies a type of jaundice. The study explores 'Phaltrikadi Kwath' for its properties against 'kamala roga', indicating the herbal formulation's potential benefits in managing symptoms associated with obstructive jaundice and related biliary issues.
5) Water:
'Water' is the solvent used in the preparation of 'Phaltrikadi Kwath'. This keyword signifies the importance of aqueous extraction in traditional herbal medicine, indicating how water serves as a medium to harness the therapeutic compounds from herbal ingredients effectively during decoction preparation.
6) Blood:
'Blood' refers to the bodily fluid that circulates at the system level, carrying nutrients, gases, and waste products. In the context of the study, blood analysis was part of patient evaluation, helping assess overall health and the physiological impacts of treatments administered post-surgery.
7) Haritaki (Har墨tak墨):
'Haritaki' is one of the herbal ingredients in 'Phaltrikadi Kwath'. Known for its antiseptic and anti-inflammatory properties, it plays a significant role in Ayurvedic medicine for its health benefits, particularly in conditions involving the digestive system and detoxification processes.
8) Amalaki (膧malak墨, 膧malaki):
'Amalaki,' another ingredient in the formulation, is celebrated for its antioxidant and restorative properties in Ayurvedic practices. It acts as a natural remedy for various ailments, including bile-related disorders, and contributes to the overall efficacy of the 'Phaltrikadi Kwath' in managing oxidative stress.
9) Kashaya (K膩峁Ｄ亂a, K膩艣aya, K膩s膩ya, Ka峁Ｄ亂a, Ka艣膩ya, K膩saya, Ka峁Ｄ亂膩, Kas膩ya, Kasaya):
'Kashaya' references a form of decoction in Ayurveda, emphasizing the preparation method of herbal formulations. The use of 'Phaltrikadi Kwath' as a 'kashaya' illustrates the traditional approach of extracting healing properties from plants through boiling them in water, creating a concentrated therapeutic liquid.
10) Shalya (艢alya, Salya):
'Shalya' pertains to the branch of Ayurveda focusing on surgery and related therapies. In this research context, it indicates the surgical interventions undertaken (cholecystectomy and choledochotomy) and the subsequent roles of combined herbal therapies in recovery and managing oxidative stress post-surgery.
11) Nausea:
'Nausea' is a common symptom experienced by patients undergoing surgery, linked to both the surgical procedure and the underlying condition. Its mention highlights the need for effective treatment strategies like 'Phaltrikadi Kwath,' which addresses these symptoms and supports recovery post-operation.
12) Sugar:
'Sugar' in this study likely refers to the measurement of fasting blood sugar levels that were evaluated as part of the hematological assessments for patients. Understanding these levels is crucial for determining overall metabolic health and managing complications during post-operative recovery.
13) Roga:
'Roga' translates to 'disease' in Ayurveda. In this research, it links to 'kamala roga', associating it with the conditions being studied and treated via 'Phaltrikadi Kwath', thereby tying traditional Ayurvedic terminology with contemporary medical diagnostics and treatments.
14) Vasa (V膩s膩, V膩sa, Vas膩, Va艣膩, Vasha):
'Vasa' is an ingredient in 'Phaltrikadi Kwath,' known for its astringent properties and its role as a tonic in traditional herbal medicine. It contributes to the overall health benefits of the formulation, particularly in treating inflammatory and digestive disorders.
15) Neem:
'Neem' is revered in Ayurveda for its diverse therapeutic properties, including anti-inflammatory and hepatoprotective effects. In 'Phaltrikadi Kwath', it enhances the formulation's ability to support liver function and combat oxidative stress, aligning with the study's objectives in managing bile conditions.
16) Tinospora cordifolia:
'Tinospora cordifolia,' commonly known as Guduchi, is noted for its immunomodulatory and antioxidant properties. Its role in the study reinforces the potential health benefits of ingredients in 'Phaltrikadi Kwath' used to combat oxidative stress in patients with biliary issues.
17) Emblica officinalis:
'Emblica officinalis,' known as Amalaki, is a primary ingredient valued in Ayurveda. This fruit is recognized for its antioxidant and rejuvenating properties, contributing significantly to the therapeutic effects of 'Phaltrikadi Kwath' in managing oxidative stress and promoting liver health.
18) Terminalia chebula:
'Terminalia chebula', referred to as Haritaki, is an important component of the formulation with diverse health benefits, including digestive health enhancement. Its inclusion in 'Phaltrikadi Kwath' signifies its relevance in treating biliary diseases and influencing oxidative stress within the patients鈥� bile.
19) Adhatoda vasica:
'Adhatoda vasica', or Vasa, is significant for its medicinal properties, especially in respiratory and detoxifying applications. In the context of 'Phaltrikadi Kwath', it illustrates the formulation's multi-dimensional effects in treating conditions beyond biliary issues, showcasing the breadth of Ayurvedic herbal medicine.
20) Pharmacological:
'Pharmacological' refers to the study of the interactions between drugs and biological systems. In this research, it highlights the investigation of the therapeutic properties of 'Phaltrikadi Kwath', emphasizing its potential biochemical effects and mechanisms related to combating oxidative stress.
21) Tuberculosis:
'Tuberculosis' is included in the patients' assessment, pointing to the necessity of evaluating systemic diseases in the context of surgery or treatment. Historical data about such diseases can impact treatment responses and must be taken into account while administering therapies like 'Phaltrikadi Kwath'.
22) Shothahara (艢othahara, Shotha-hara):
'Shothahara' denotes properties related to the reduction of swelling or inflammation. This term emphasizes the therapeutic effects of 'Phaltrikadi Kwath' in addressing not only the symptoms of biliary diseases but also the resultant inflammation caused by surgical trauma.
23) Kamalahara (K膩mal膩hara, Kamala-hara):
'Kamalahara' refers to the properties that combat jaundice. This term closely relates to the context of 'Phaltrikadi Kwath', aligning with its use against obstructive jaundice and underlining its therapeutic significance in Ayurveda for enhancing liver function and health.
24) Discussion:
'Discussion' entails the section where findings and implications of the research are explored in-depth. In this context, it represents the analysis of results related to oxidative stress, evaluating the effectiveness of 'Phaltrikadi Kwath' and addressing how the formulations engage with patient health outcomes.
25) Vibhitaki (Vibh墨tak墨):
'Vibhitaki', an ingredient in 'Phaltrikadi Kwath', possesses several health benefits. Its role as a choleretic and antipyretic agent promotes digestive health and assists in treating jaundice, reinforcing the formulation's purpose in managing biliary conditions prevalent in the patient population studied.
26) Ayurveda (膧yurveda, Ayus-veda):
'Ayurveda' is a traditional system of medicine originating from India, focusing on holistic health and natural therapies. This study represents an application of Ayurvedic principles through the use of herbal formulations, highlighting the integration of ancient wisdom with modern medical research.
27) Vomiting:
'Vomiting' is a symptom frequently associated with cholelithiasis and post-operative recovery. The consideration of vomiting in the study underscores the importance of finding effective herbal treatments like 'Phaltrikadi Kwath' to alleviate such symptoms in patients undergoing surgical procedures.
28) Samhita (Sa峁僪it膩, Sa峁僪ita):
'Samhita' refers to classical texts that comprise core principles of Ayurveda. In this research, mentioning 'Samhita' implies a connection to traditional knowledge bases that guide the formulation and utilization of herbal concoctions like 'Phaltrikadi Kwath' for treating various medical conditions.
29) Samaka (S膩m膩ka, Shamaka, S膩maka):
'Shamaka' signifies the properties that balance the body's energies in Ayurveda. This term depicts the holistic approach of 'Phaltrikadi Kwath', suggesting how the formulation not only treats symptoms but also promotes overall balance and restoration of health post-surgery.
30) Shruti (Sruti, 艢ruti, 艢rut墨):
'Shruti' refers to the sacred texts of Ayurveda communicated through oral tradition. Its mention emphasizes the historical and theoretical foundations of Ayurvedic practices that inform the development and application of formulations like 'Phaltrikadi Kwath' used in therapies.
31) Bitter:
'Bitter' describes one of the predominant tastes revered in Ayurveda, aligning with herbal properties encouraging various physiological functions. Many ingredients in 'Phaltrikadi Kwath', including Vibhitaki, carry bitter attributes, contributing to their effectiveness in digestion and detoxification within the bile.
32) Hari (H膩ri, H膩rin, Har墨, Harin):
'Hari' is an integral part of the authors' names, likely pertaining to the contributing researchers involved in the study. It emphasizes the collaborative effort in conducting the research and developing insights on the efficacy of 'Phaltrikadi Kwath' based on rigorous scientific evaluation.
33) Vati (V膩ti, V膩峁�, Vat墨, Va峁璱):
'Vati' refers to a form of Ayurvedic medicine prepared as tablets or pills. This term reinforces the understanding of the forms in which Ayurvedic therapies can be administered, as compared to 'kashaya' or decoctions, indicating the variety of treatment modalities available within this traditional system.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Oxidative Stress Evaluation After Polyherbal Therapy in Cholelithiasis鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Control group, Oxidative stress, Lipid peroxidation, Phaltrikadi kwath, Antioxidant potential, Hepatoprotective drug, Physico-chemical studies, Free Radical Chain Reaction, Clinical model, Bile Juice, Post-Operative Day, Surgeon, T-tube Drainage.