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"Pentapala-04: Herbal Antiasthmatic for Lung Damage in Rats"

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Journal name: Ancient Science of Life
Original article title: Antiasthmatic Role of “Pentapala -04� a Herbal Formulation Against Ova Albumin and Aluminium HydroxideInduced LungDamage in Rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

D. Srinivasa Rao, Indira A. Jayaraaj, R. Jayaraaj


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Antiasthmatic Role of “Pentapala -04� a Herbal Formulation Against Ova Albumin and Aluminium HydroxideInduced LungDamage in Rats

Year: 2005

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

Bronchial asthma is a prevalent chronic disease characterized by airway obstruction and increased resistance to airflow. The rising incidence is attributed to environmental factors such as allergens and pollutants, leading to a higher demand for effective treatments. Traditional antiasthmatic therapies, notably corticosteroids, although effective, present challenges related to cost and potential severe side effects. This study explores the antiasthmatic potential of a herbal formulation named "Pentapala-04," composed of five medicinal plants, in a rat model of lung damage induced by ova albumin and aluminum hydroxide.

Role of Antioxidants in Lung Health

The research highlights the significance of oxidative stress as a contributory factor in lung diseases, including asthma. In pathological conditions, the balance between pro-oxidants and antioxidants is disrupted, resulting in increased lipid peroxidation that damages cell membranes. The study found that treatment with "Pentapala-04" restored the levels of key antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, in rats subjected to oxidative stress from the induction of lung damage. The herbal formulation demonstrated the ability to scavenge reactive oxygen species and mitigate oxidative damage, thereby indicating its potential as a therapeutic agent against asthma-related lung injury.

Conclusion

The findings of the study provide evidence that "Pentapala-04" effectively counteracts oxidative stress and lung injury induced by ova albumin and aluminum hydroxide in rats. By reducing lipid peroxidation and restoring antioxidant enzyme levels, this herbal formulation shows promise as a potential natural alternative for asthma treatment. The results advocate for further investigation into its application for managing oxidative stress-related lung diseases, underscoring a growing interest in utilizing herbal compounds in modern therapeutic strategies.

FAQ section (important questions/answers):

What is bronchial asthma and its common treatments?

Bronchial asthma is characterized by wheezing and airflow resistance. Common treatments include corticosteroids, which effectively manage asthma but may have severe side effects and high costs.

What is Pentapala-04 and its components?

Pentapala-04 is a herbal formulation made from five medicinal plants: Adhatoda vasica, Ocimum sanctum, Coleus aromaticus, Glycyrrhiza glabra, and Alpinia galangal. It is used to prevent lung damage.

How was asthma induced in the study's rats?

Asthma was induced in rats by injecting them with a saline solution containing ova albumin and aluminum hydroxide, along with Bordetella pertussis vaccine for 21 days.

What were the study’s main findings about Pentapala-04?

The study found that Pentapala-04 significantly reduced oxidative stress and lipid peroxidation in lung tissues of rats, indicating its potential as an effective antiasthmatic treatment.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for �"Pentapala-04: Herbal Antiasthmatic for Lung Damage in Rats"�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drug refers to any substance that causes a physiological effect when introduced to a living organism. In the context of this study, Pentapala-04 is the herbal formulation investigated for its potential in treating bronchial asthma and lung damage by mitigating oxidative stress, showing its significance as a therapeutic option.

2) Activity:
Activity in this context pertains to the biological effects demonstrated by Pentapala-04 on lung tissues exposed to damaging agents like ova albumin and aluminum hydroxide. The measured activities of various antioxidants in the study highlight the formulation's role in combating oxidative stress and its potential as an antiasthmatic treatment.

3) Glycyrrhiza glabra:
Glycyrrhiza glabra, commonly known as licorice, is one of the five medicinal plants in the Pentapala-04 formulation. Known for its antioxidant properties, it contributes to the overall efficacy of the drug against oxidative damage, supporting lung function, and providing a natural alternative in asthma treatment.

4) Medicine:
Medicine encompasses a broad field focused on the diagnosis, treatment, and prevention of disease. This research underscores the importance of herbal medicine, particularly the study of Pentapala-04, highlighting its role as a viable, cost-effective, and less harmful alternative to conventional corticosteroids for asthma treatment.

5) Science (Scientific):
Science, or the systematic study of the natural world, underpins this research. The principles of biochemistry and zoology employed in evaluating Pentapala-04 reflect the interdisciplinary approach necessary for understanding complex biological systems and developing effective herbal treatments for respiratory conditions like asthma.

6) Diet:
Diet refers to the nutritional regimen that provides necessary sustenance for health. In this study, the standard pellet diet given to the rats ensures that the effects of Pentapala-04 on lung damage and oxidative stress are not confounded by variations in nutritional intake, ensuring scientific rigor.

7) Post:
Post refers to actions taken after a particular event or treatment. In this study, it describes the post-treatment phase where rats receiving Pentapala-04 showed restoration of antioxidant levels and reduced lipid peroxidation, underlining the formulation's effectiveness in mitigating oxidative damage after induced lung injury.

8) Adhatoda vasica:
Adhatoda vasica, also known as Vasaka, is a vital component of Pentapala-04. Its traditional use in treating respiratory disorders, along with its antioxidant properties, contributes to the overall efficacy of this herbal formulation in alleviating conditions such as asthma and airway inflammation, justifying its inclusion.

9) Ocimum sanctum:
Ocimum sanctum, or holy basil, recognized for its therapeutic benefits, is another key ingredient in Pentapala-04. Its anti-inflammatory and antioxidant properties play a protective role against oxidative stress in lung tissues, making it an important herb for respiratory health in the formulation being studied.

10) Water:
Water is a critical solvent and medium in biological research. In the preparation of Pentapala-04's aqueous extracts, water's role ensures the extraction of medicinal compounds from the plant materials, facilitating their bioactivity evaluation and being essential for the physiological experiments conducted with the rats.

11) Bronchial asthma:
Bronchial asthma is a chronic inflammatory disease of the airways characterized by wheezing, breathlessness, and chest tightness. This study aims to address asthma's pathophysiological mechanisms and explore Pentapala-04 as a treatment strategy for lung damage, reflecting the pressing need for novel therapeutic interventions.

12) Inflammation:
Inflammation is a biological response to harmful stimuli such as pathogens or irritants, contributing to diseases like asthma. The study highlights the anti-inflammatory effects of Pentapala-04 in reducing lung inflammation induced by toxic agents, indicating its potential use as a natural anti-inflammatory agent.

13) Discussion:
Discussion refers to the section where study findings are interpreted in the context of existing literature. Here, it assesses the significance of results obtained from experiments on Pentapala-04, linking observed antioxidant activity to potential therapeutic benefits, and comparing them with previous studies on asthma treatments.

14) Substance:
Substance refers to any material with a defined chemical composition. In this study, Pentapala-04 is evaluated as a therapeutic substance derived from various plants. Understanding its composition and the bioactive compounds involved is crucial for recognizing its potential health benefits and mechanisms in treating lung disorders.

15) Zoology:
Zoology is the scientific study of animals and their behavior, physiology, and classification. This study employs zoological principles through experiments on Wistar rats, facilitating insights into how the herbal formulation impacts biological systems, ultimately contributing to knowledge of animal models in disease research and treatment.

16) Palani (Pālanī, Pazhani):
Palani refers to a geographical location in Tamil Nadu, India, where the medicinal plants used to prepare Pentapala-04 were collected. This area's biodiversity contributes to the formulation's unique properties, emphasizing the importance of local flora in traditional medicine and its applications in modern herbal therapeutics.

17) Cancer:
Cancer represents a range of diseases characterized by uncontrolled cell growth. While the primary focus of this study is asthma, the oxidative stress mechanisms illustrated in respiratory diseases have parallel implications for cancer, suggesting that herbal formulations like Pentapala-04 might also have broader protective effects against oxidative damage.

18) Reason:
Reason refers to the underlying causes or motivations behind a phenomenon. In this study, it addresses why Pentapala-04 was selected for investigation, emphasizing the rising prevalence of asthma, the limitations of conventional treatments, and the urgent need for effective, safer alternatives derived from natural sources.

19) Simha (Siṃha):
Sinha refers to the author of the referenced methods used for biochemical analysis during the study. This citation reflects the reliance on standardized procedures in scientific investigations, ensuring the reliability and reproducibility of results obtained when assessing the antioxidant levels and oxidative stress in experimental subjects.

Other Science Concepts:

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Discover the significance of concepts within the article: �"Pentapala-04: Herbal Antiasthmatic for Lung Damage in Rats"�. Further sources in the context of Science might help you critically compare this page with similair documents:

Chronic disease, Environmental factor, Experimental design, Herbal formulation, Oxidative stress, Lipid peroxidation, Reduced glutathione, Superoxide dismutase, Catalase, Herbal drug, Respiratory disease, Free Radical, Vitamin E, Antioxidant enzyme, Aluminum hydroxide.

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