Significance of Particle size reduction
Particle size reduction is a crucial technique in drug formulation that involves decreasing the size of drug particles to enhance their absorption, solubility, and dissolution rates. This process increases the surface area of the particles, allowing for improved interaction with solvents, ultimately leading to better bioavailability and therapeutic effectiveness. By reducing particle size, especially in poorly soluble drugs, formulation strategies aim to enhance drug delivery performance and efficacy, making it a vital approach in pharmaceutical development.
Synonyms: Comminution, Milling, Grinding, Pulverization, Attrition, Fragmentation, Size reduction, Micronization, Crushing
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The concept of Particle size reduction in scientific sources
Particle size reduction is crucial for enhancing drug solubility and bioavailability by decreasing particle sizes from microns to nanometers, thereby improving dissolution rates of poorly soluble drugs, such as itraconazole, during pharmaceutical processing.
From: World Journal of Pharmaceutical Research
(1) A process in solid dispersions that decreases the size of drug particles to increase their surface area for improved dissolution.[1] (2) The process of decreasing the particle size of a drug to enhance its surface area, which is crucial for improving dissolution and absorption.[2] (3) The process of minimizing particle size in solid systems, leading to an increased surface area that promotes dissolution.[3] (4) A process where the size of particles is decreased, often through techniques such as grinding, to produce granulated materials with improved properties.[4] (5) A method aimed at improving the dissolution and absorption of drugs by decreasing their particle size.[5]
From: Ancient Science of Life
(1) The process of minimizing the size of particles in Mandura bhasma, which increases its absorption and therapeutic effectiveness.[6]
From: AYU (Journal of Research in Ayurveda)
(1) The significant decrease in the size of the grains from raw material (5-10 microns) to the final Bhasma product (50-200 nm) during the pharmaceutical process.[7]