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Significance of LD 50

LD 50, or the median lethal dose, is a crucial measure used to assess the toxicity of substances, indicating the dose required to kill 50% of a test population, typically in animal studies. In research involving various plant extracts, LD 50 values have been determined, providing insights into their safety levels. For example, Gossypium herbaceum extracts have an LD 50 of 3000 mg/kg, while other substances exhibited varying toxicity levels. This metric helps evaluate the safety and potential risks associated with different extracts.

Synonyms: Lethal dose 50, Median lethal dose, Ld50, Toxic dose

The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.

The concept of LD 50 in scientific sources

Science Books

LD 50, or lethal dose 50, indicates the amount of a substance required to kill 50% of a test population, crucial for assessing toxicity levels, particularly in studies involving venom extracts.

Significance in Scientific journals, articles, etc.:

From: World Journal of Pharmaceutical Research

(1) The lethal dose required to kill half the members of a tested population, calculated during the acute toxicity study.[1] (2) Lethal dose required to kill 50% of a test population, which was estimated to be greater than 5000 mg/kg for ELSV.[2] (3) The lethal dose required to kill half the members of a tested population, used to evaluate the toxicity of plant extracts.[3] (4) The dosage at which 50% of a test population (usually in animal studies) dies, calculated by taking the square root of the multiplication of the highest dose causing no death and the lowest dose causing death.[4] (5) The lethal dose of a substance that kills 50% of a test population, determined for HASI in the toxicity study.[5]

From: International Ayurvedic Medical Journal

(1) The lethal dose of a substance that kills 50% of a test population, such as with the venoms used in the study to calculate appropriate dosing.[6] (2) Lethal dose required to kill 50% of the test subjects, calculated to determine the toxicity levels of the extracts.[7]

From: Ancient Science of Life

(1) The dose of extract that could be lethal to 50% of a test sample, indicating its toxicity level.[8]

From: Ayushdhara journal

(1) The lethal dose of a substance required to kill 50% of a test population, used as a measure of acute toxicity.[9]

This section includes scientific research in the field of healthcare, often involving traditional medicine systems such as Ayurveda, Unani, Siddha and Holistic health. It includes papers from scientific journals classified as either original, clinical or experimental research, review articles or case reports.