Significance of Toxic dose
Toxic dose refers to a quantity of a substance, such as acetaminophen, that can cause harmful effects on living organisms. It is often defined by a significant reduction in body weight of 10% or more or by exceeding safe limits of medication, which could result in serious adverse reactions. Toxic doses are crucial for assessing the safety of various substances, as they indicate high amounts that may lead to severe health issues, including potential lethality.
Synonyms: Lethal dose, Excessive dose
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The concept of Toxic dose in scientific sources
Toxic dose signifies a medication amount that causes significant adverse effects, defined as a loss of 10% body weight or more. It exceeds safe limits, leading to potentially serious health repercussions.
From: World Journal of Pharmaceutical Research
(1) A quantity of a substance that produces harmful effects on living organisms, as observed in experimental studies.[1] (2) High amounts of a substance that are harmful and can lead to severe health consequences, such as liver necrosis.[2] (3) A dose that leads to a reduction of 10% or more in body weight, indicating potential toxicity.[3] (4) A quantity of a substance, specifically acetaminophen in this case, that is sufficient to induce harmful effects, applied in the experimental protocol of the study.[4] (5) Quantities of a substance that are harmful or lethal when ingested or absorbed, used for classifying the safety of various rodenticides.[5]