Significance of Controlled release formulation
Controlled release formulation refers to advanced drug delivery systems that regulate the rate at which a drug is released into the body, thereby enhancing therapeutic efficacy and improving patient compliance. These formulations are designed to maintain a stable concentration of the active ingredient over a prolonged period, reducing fluctuations in drug levels and minimizing side effects. By releasing the medication at a predetermined rate, they allow for effective management of therapy while decreasing the need for frequent dosing.
Synonyms: Sustained release formulation, Extended release formulation, Time-release formulation, Delayed release, Extended release, Sustained release, Modified release, Prolonged release
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The concept of Controlled release formulation in scientific sources
Controlled release formulation involves drug delivery systems that gradually release the active ingredient over a designated time, enhancing therapeutic efficacy, maintaining consistent drug levels, and improving patient compliance while reducing side effects.
From: World Journal of Pharmaceutical Research
(1) Medications that provide a steady release of the active ingredient over a prolonged period, aimed at reducing fluctuations in drug levels in the bloodstream.[1] (2) Controlled release formulations of azathioprine were developed based on osmotic technology, allowing for a sustained release of the drug over time.[2] (3) Drug formulations that modify oral absorption by controlling the rate at which a drug is released into the body.[3] (4) Tablet formulations designed to release their active ingredient at a predetermined rate over time.[4] (5) A formulation designed to release a drug in a controlled manner over time, specifically mentioned concerning tramadol hydrochloride using hydrophilic and hydrophobic matrix systems.[5]