Significance of Modified release
Modified release refers to drug formulations designed to alter the timing and/or rate of drug release to achieve improved therapeutic outcomes compared to conventional products. This strategy allows for slow drug release over time, maintaining therapeutic levels with less frequent dosing, as exemplified by gliclazide. Additionally, modified release systems, such as those optimizing paracetamol from microspheres, implement specific release patterns like delayed or extended release formats to enhance drug delivery and effectiveness.
Synonyms: Enhanced release, Extended release, Sustained release, Controlled release, Timed release, Prolonged release, Delayed release
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The concept of Modified release in scientific sources
Modified release pertains to pharmaceutical systems that adjust the release pattern of medications, including delayed or extended release formats, optimizing therapeutic effects and enhancing patient adherence to treatment regimens.
From: World Journal of Pharmaceutical Research
(1) A formulation approach that alters the release rate of drugs using different types of carriers in liquisolid systems.[1] (2) Formulations that alter the timing and/or duration of drug release compared to conventional forms.[2] (3) Products designed to alter the timing and/or rate of drug release to achieve therapeutic outcomes not provided by conventional formulations.[3] (4) A formulation strategy designed to release a drug slowly over time, as seen in gliclazide products, to maintain therapeutic levels without frequent dosing.[4] (5) A delivery system design that alters the timing and/or rate of release of a drug from a formulation, as indicated by the study's aim to optimize the release of paracetamol from microspheres.[5]