Significance of Apoptotic pathway
The apoptotic pathway encompasses a series of processes critical for programmed cell death, impacting cancer development and treatment resistance. This pathway can be activated by various stimuli, including extracts like Eclipta, and is essential in regulating the elimination of damaged cells. Its dysfunction is noted in multiple cancers, including breast cancer, where disruptions can hinder apoptosis. Understanding these biochemical events is vital for developing strategies to enhance cancer therapies targeting the apoptosis pathway, potentially leading to improved patient outcomes.
Synonyms: Apoptotic process, Death receptor pathway, Intrinsic pathway, Extrinsic pathway, Apoptosis cascade
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Apoptotic pathway in scientific sources
The Apoptotic pathway involves programmed cell death, activated in breast cancer cells by Eclipta extract through the intrinsic pathway. Targeting these cellular pathways can enhance the effectiveness of cancer therapies.
From: The Malaysian Journal of Medical Sciences
(1) This biological process is discussed in the text, specifically regarding its involvement in the death of specific neurons, and is a target for potential treatments.[1] (2) This is a biological process that leads to programmed cell death, and the RASSF1 gene is involved in this pathway.[2] (3) Programmed cell death will occur when the cell factors are involved in the apoptosis pathway activation, and the cell tumours will be inactive, which destroys the cancer cells.[3] (4) This is a pathway that is dysfunctional in multiple cancers, and its failure to carry out in breast cancer cells might be attributed to disruptions within it.[4] (5) The processes by which cells undergo programmed cell death, regulated by various pro-apoptotic and anti-apoptotic proteins.[5]