Significance of Extrinsic pathway
The extrinsic pathway refers to two main biological processes: first, it is a mechanism of apoptosis initiated by external signals binding to cell surface receptors, leading to cell death. Second, it is a route to blood coagulation that relies on tissue factors released when vessel walls rupture, triggering the coagulation cascade and ultimately leading to clotting. This pathway plays a critical role in activating factor X and is influenced by external trauma and certain venoms.
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The concept of Extrinsic pathway in scientific sources
The Extrinsic pathway involves two vital processes: it triggers apoptosis via death receptor interactions and serves as a blood coagulation route activated by tissue factors released from damaged blood vessel walls.
From: The Malaysian Journal of Medical Sciences
(1) These are the external processes that regulate regeneration, including factors like myelin and glial scar, as well as axon guidance and elements within the extracellular matrix.[1] (2) Cellular processes stimulated by external signals, such as TRAIL, that can lead to programmed cell death, as mentioned in the text.[2]