Journal name: World Journal of Pharmaceutical Research
Original article title: Acute pancreatitis under methylprednisolone bolus
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a case report
Original source:
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Salma Ouahid, Najoua Mouloudi, Imane Radouane, Sanaa Berrag, Tarik Addioui, Mouna Tamzaourte, Ahmed bouraza and Aziz Aourarh
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Acute pancreatitis under methylprednisolone bolus
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20221-22607
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Drug-induced acute pancreatitis (AP) is a rare condition, occurring in less than 2% of cases among adults. Among the various medications that have been associated with this condition, corticosteroids are infrequently noted as potential culprits. This article presents an unusual case of recurrent acute pancreatitis in a patient who received infusions of methylprednisolone for the treatment of multiple sclerosis (MS), highlighting the connection between corticosteroid treatment and the onset of pancreatitis.
Methylprednisolone and its Effects on the Patient
The case involves a 32-year-old female patient diagnosed with relapsing-remitting multiple sclerosis, who was undergoing disease-modifying interferon therapy. During her treatment, she was admitted twice due to sensitive flare-ups necessitating the administration of a 1 g/day bolus of methylprednisolone for three consecutive days. On the third day of each hospitalization, the patient experienced severe epigastric pain, accompanied by nausea and vomiting, which triggered elevated pancreatic enzyme levels, indicating acute pancreatitis. Imaging studies confirmed stage B pancreatitis as per the Balthazar classification, ruling out other potential causes.
Establishing the Role of Corticosteroids
In this specific clinical observation, the relationship between the administration of methylprednisolone and the emergence of pancreatitis was evaluated. Despite an absence of a clear etiology for the episodes, the suspicion was raised that corticosteroid therapy contributed to the development of pancreatitis. The importance of carefully assessing the chronology of drug administration and the onset of symptoms was emphasized, as establishing the drug as a cause relies on ruling out other etiologies, particularly biliary issues, which can complicate diagnosis.
Treatment Adjustments and Outcomes
To mitigate the risk of further pancreatic complications, a dosage adjustment was made during the patient's third hospitalization, reducing the methylprednisolone dose to 500 mg/day for six days, administered on alternate days. Close monitoring of clinical status and daily pancreatic enzyme levels were implemented. This strategic management resulted in no adverse digestive events and considerable improvement in the patient’s neurological symptoms, displaying a positive outcome from the adjusted treatment regimen.
Conclusion
The case demonstrates that corticosteroids can induce acute drug-related pancreatitis, a condition that remains under-recognized in clinical practice. While predictive factors for drug-induced pancreatitis are not well established, it is crucial for healthcare professionals to report any instances associated with corticosteroid use to pharmacovigilance centers. Increased awareness and reporting can enhance understanding of this adverse event, which may assist in better management of patients receiving corticosteroid therapies.
FAQ section (important questions/answers):
What is the prevalence of drug-induced acute pancreatitis?
Drug-induced acute pancreatitis is rare, affecting less than 2% of adults, but corticosteroids are seldom reported as a cause.
What condition was the patient treated for with methylprednisolone?
The patient was treated for relapsing-remitting multiple sclerosis and received methylprednisolone infusions.
What symptoms did the patient experience during hospitalization?
The patient experienced severe epigastric pain, nausea, vomiting, and elevated pancreatic enzymes.
How was the patient's pancreatitis treated during the second episode?
The treatment involved reducing methylprednisolone dosage to 500 mg daily, monitored closely for symptoms.
What diagnostic challenges exist in identifying drug-induced pancreatitis?
Diagnosing drug-induced pancreatitis is challenging since symptoms can resemble other types of pancreatitis without specific indicators.
What should healthcare professionals do regarding suspected cases of pancreatitis?
Healthcare professionals must report any suspected drug-induced pancreatitis cases to pharmacovigilance centers for further investigation.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Acute pancreatitis under methylprednisolone bolus�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
A drug is a substance that causes a physiological change in the body. In the context of the article, certain medications, such as corticosteroids, can lead to adverse effects like drug-induced acute pancreatitis. Understanding drug interactions and their side effects is crucial for effective patient care and safety.
2) Observation:
Observation refers to the act of closely monitoring a patient's condition or a specific clinical case. In medical practice, careful observation helps in identifying symptoms, diagnosing conditions accurately, and evaluating treatment responses. This report emphasizes the importance of clinical observation in recognizing drug-related complications.
3) Teaching:
Teaching in the medical context refers to the process of educating healthcare professionals and patients about diseases, treatment protocols, and drug side effects. Effective teaching enhances understanding of clinical practices, fosters awareness of drug reactions, and promotes patient safety, which is crucial in managing conditions like multiple sclerosis.
4) Science (Scientific):
Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. The report utilizes scientific methods to analyze case studies, aiming to clarify the connection between corticosteroids and pancreatitis, thereby enhancing understanding within the field of medical research.
5) Disease:
Disease refers to any deviation from the normal structure or function of a body part, often characterized by specific signs or symptoms. The article discusses multiple sclerosis, a chronic disease affecting the central nervous system, and how its treatment can inadvertently lead to complications like pancreatitis, highlighting treatment complexities.
6) Discussion:
Discussion in a clinical setting involves examining various aspects of a case and interpreting findings collaboratively. The discussion in this case report focuses on the unusual incidence of drug-induced acute pancreatitis and the implications for treatment, providing insights that can guide future clinical decision-making and research.
7) Vomiting:
Vomiting is a physiological response characterized by the involuntary expulsion of stomach contents through the mouth. In the context of acute pancreatitis, vomiting is a common symptom observed in patients experiencing abdominal pain and complications, indicating the severity of the condition and the need for immediate medical intervention.
8) Nausea:
Nausea is a sensation of unease in the stomach that often precedes vomiting. It is significant in clinical assessments as it can indicate underlying conditions such as pancreatitis. Understanding nausea in relation to drug therapy is vital for managing patient comfort and treatment efficacy, especially in acute medical situations.
9) Study (Studying):
A study is a detailed investigation aimed at discovering new information or confirming existing knowledge. The case presented in the article contributes to the existing literature on the relationship between medications and acute pancreatitis, fostering further research into drug-related side effects and their clinical implications.
10) Shana (Sana):
Sanaa, in this context, likely refers to one of the authors or contributors involved in the case study. The inclusion of multiple authors emphasizes collaboration in medical research, reflecting how teamwork in different specialties can enrich clinical understanding and lead to comprehensive studies on complex medical issues.
11) Bile:
Bile is a digestive fluid produced by the liver, crucial for the emulsification and absorption of fats in the digestive process. Its relevance in pancreatitis lies in the potential for biliary obstruction to cause acute pancreatitis. Understanding the role of bile aids in diagnosing and treating pancreatitis systematically.
12) Sign:
A sign refers to an objective indicator of a condition that can be observed or measured by healthcare professionals. In the context of the article, understanding the signs of acute pancreatitis is critical for diagnosis and patient management, highlighting the importance of clinical evidence in evaluating treatment responses.
13) Pain:
Pain is a critical sensation that alerts individuals to injury or disease. In acute pancreatitis, severe abdominal pain is a defining symptom, guiding clinicians to make swift treatment decisions. Recognizing and managing pain effectively is crucial in enhancing patient quality of life and ensuring appropriate medical responses.
14) Hand:
Hand, in a medical context, often refers to the practice and skills involved in patient care. Proper physical examination techniques, such as palpation and assessment of abdominal pain, are essential for diagnosing conditions like pancreatitis. The 'hand' symbolizes the practical application of medical knowledge in clinical settings.
Other Science Concepts:
Discover the significance of concepts within the article: �Acute pancreatitis under methylprednisolone bolus�. Further sources in the context of Science might help you critically compare this page with similair documents:
Acute Pancreatitis, Multiple sclerosis, Non-invasive test, Predictive Factors, Pharmacovigilance center.