Evaluation of subchronic genotoxic potential of Swarna Makshika Bhasma
Journal name: AYU (Journal of Research in Ayurveda)
Original article title: Evaluation of subchronic genotoxic potential of Swarna Makshika Bhasma
AYU is an internationally recognized quarterly journal dedicated to advancing research in Ayurveda. The journal covers a wide range of topics, including clinical and pharmacological research in Ayurveda's eight branches, herbal remedies, phytochemistry, and ethnomedicine.
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Pavan B. Savalgi
Biswajyoti Patgiri
Jalaram H. Thakkar
B. Ravishankar
Varun B. Gupta
AYU (Journal of Research in Ayurveda):
(An International Quarterly Journal of Research in Ayurveda)
Full text available for: Evaluation of subchronic genotoxic potential of Swarna Makshika Bhasma
Year: 2012 | Doi: 10.4103/0974-8520.108858
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Extremely diminutive published information is available on the mutagenic activity of Ayurvedic Bhasmas. Genotoxicity of few Bhasmas were reported on single maximum dose, but no reference is available on the sub-chronic level. Hence the present study was carried to generate and evaluate genotoxic potentials of Swarna Makshika Bhasma (mineral preparation) administered at therapeutic dose for 14 days. Chromosomal aberrations and abnormal sperm assay parameters were taken in this study. Cyclophosphamide (CP) was taken as positive group and results were compared. The results revealed a lack of generation of structural deformity in above parameters by tested drugs compared to CP treated group. Observed data indicate that the Bhasmas tested were non-genotoxic under the experimental conditions. Keywords: Abnormal sperm assay, chromosomal aberrations, cyclophosphamide, genotoxicity, Swarna Makshika Bhasma
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Statistical analysis, Traditional medical system, Classical method, Body weight, Acclimatization period, Cyclophosphamide, Genotoxicity, Swarna Makshika Bhasma, Metal toxicity, Chromosomal aberration, Experimental Condition.