Anti-inflammatory activity of cassia aauriculata
Journal name: Ancient Science of Life
Original article title: Anti-inflammatory activity of cassia aauriculata
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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S. Manogaran, N. Sulochana
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Anti-inflammatory activity of cassia aauriculata
Year: 2004
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Cassia auriculata, a shrub belonging to the Caesalpiniaceae family, is commonly found in regions like Sri Lanka, India, and Burma, and is known for its medicinal properties. The flowers of this plant are traditionally used to treat ailments such as urinary discharge, nocturnal emissions, diabetes, and throat issues. A significant focus of the research conducted by S. Manogaran and N. Sulochana is the anti-inflammatory properties of C. auriculata, particularly through the study of its flower extracts.
Anti-Inflammatory Activity of C. auriculata
The study demonstrated that the 50% acetone extract of C. auriculata's flowers exhibited notable anti-inflammatory activity, specifically showing a 56% reduction in carrageenin-induced oedema in male albino rats. The research utilized a rigorous methodology where the extract was prepared from shade-dried flowers and tested against a control group and a positive control group receiving ketorolac tromethamine. The findings indicated that the anti-inflammatory efficacy of the extract could be linked to its ability to inhibit the release of inflammatory mediators such as histamine, serotonin, and prostaglandins, which are typically responsible for the inflammatory response.
Conclusion
The investigation into the anti-inflammatory properties of Cassia auriculata highlights its potential therapeutic applications, particularly in managing inflammation-related conditions. The encouraging results from the studies underscore the importance of traditional medicinal plants and their extracts in developing new treatments for inflammation and related ailments. Ongoing research and acknowledgment from institutions such as AICTE further bolster the significance of this work and its contribution to the field of medicinal chemistry and pharmacology.
FAQ section (important questions/answers):
What was the objective of the study on Cassia auriculata?
The study aimed to evaluate the anti-inflammatory activity of Cassia auriculata using physical and chemical analysis of its flower extracts, particularly focusing on their effectiveness in reducing inflammation in rats.
How was the extract of Cassia auriculata prepared for the study?
The extract was prepared by shade drying 1 kg of fresh yellow flowers and then extracting it with 50% acetone in a Soxhlet apparatus, resulting in a solid residue yield of 0.5%.
What method was used to induce inflammation in the study?
Carrageenin was used to induce rat hind paw oedema, a common method to study inflammation. The paw volume was measured before and after injection to assess the effectiveness of treatments.
What were the findings regarding the anti-inflammatory activity?
The study found that the 50% acetone extract of Cassia auriculata exhibited significant anti-inflammatory activity, showing a 56% reduction in oedema compared to the control group, indicating its potential therapeutic benefits.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-inflammatory activity of cassia aauriculata�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In the context of the study, 'Activity' refers to the effect of Cassia auriculata in reducing inflammation as measured by oedema in rats. The anti-inflammatory activity signifies the potential medicinal value of the plant, indicating it may help alleviate conditions characterized by excessive inflammation. This aspect is crucial in pharmacological research.
2) Edema (Oedema):
Oedema is the swelling caused by excess fluid trapped in body tissues, and in this study, it is induced by injection of carrageenin in rat paws. The measurement of oedema is a standard method to assess the anti-inflammatory activity of substances. Understanding oedema patterns allows researchers to evaluate therapeutic effectiveness.
3) Inflammation:
Inflammation is the body’s response to injury or infection, characterized by redness, heat, swelling, and pain. This research investigates the anti-inflammatory properties of Cassia auriculata, aiming to identify natural substances that can mitigate inflammatory responses. Understanding inflammation is essential for developing new treatments for various diseases.
4) Drug:
'Drug' in this study refers to a substance used for medical treatment. Cassia auriculata's extracts are evaluated for their potential as anti-inflammatory drugs, which could offer alternatives to conventional pharmaceuticals, minimizing side effects. This exploration highlights the importance of natural products in drug discovery.
5) Discussion:
'Discussion' is an important section in research articles where results are interpreted. In this study, the discussion would encompass the implications of the findings concerning the anti-inflammatory activity of C. auriculata, its mechanisms, and potential applications in medicine, contributing to the scientific understanding of traditional remedies.
6) Substance:
'Substance' refers to a material with a particular chemical composition or properties. In this context, Cassia auriculata extract is a biological substance assessed for its pharmacological effects. Understanding the nature of this substance helps in elucidating its medicinal properties and potential therapeutic applications.
7) Science (Scientific):
'Science' represents the systematic study of the structure and behavior of the physical and natural world. This research exemplifies the scientific approach in exploring the anti-inflammatory properties of plant extracts, emphasizing methodology, experimentation, and analysis, which is fundamental to advancing medical knowledge and therapies.
8) Botany:
'Botany' is the branch of biology dealing with plant life. The study focuses on a plant species, Cassia auriculata. Knowledge of botany is essential for researchers to identify, classify, and understand the medicinal properties of plants, thereby aiding in the exploration of herbal pharmacology.
9) Water:
'Water' is a crucial solvent in biological studies and is used in the preparation of solutions. In this research, it is mentioned as an accessible resource for the rats during experiments. Water is also essential for plant growth and influences the extraction process of medicinal compounds.
10) Soil:
'Soil' is the upper layer of earth where plants grow, essential for providing nutrients, water, and support. Understanding the soil's quality surrounding Cassia auriculata can impact plant health and the chemical composition of extracts, which are critical for evaluating their efficacy in anti-inflammatory activity.
Other Science Concepts:
Discover the significance of concepts within the article: �Anti-inflammatory activity of cassia aauriculata�. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Anti-inflammatory activity, Positive control, Ancient Science of life, Department of Botany, Physical and chemical methods, Carrageenin-Induced Oedema, Male Albino Rat, Carrageenin induced rat paw oedema, Encouragement and support.