Coenzyme q 10 : a review
Journal name: Ancient Science of Life
Original article title: Coenzyme q 10 : a review
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Deependra Singh, Vandana Jain, Swarnlata Saraf, S Saraf
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Coenzyme q 10 : a review
Year: 2002
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Coenzyme Q10, also known as Ubiquinone or Co Q10, is a vitamin-like substance crucial for energy production in cells, predominantly found in the membranes of mitochondria. It operates as a cofactor for mitochondrial enzymes (complexes I, II, and III), facilitating oxidative phosphorylation, and plays a vital role in converting food into energy. Co Q10 also serves as a potent antioxidant, protecting cells from oxidative damage. This nutrient is particularly significant for organs with high metabolic demands, such as the heart, liver, and brain, and has been shown to influence the progression of various cardiovascular diseases through its capacity to maintain optimal cellular functions.
Cardiovascular Health and Coenzyme Q10
Co Q10 has garnered attention for its therapeutic potential in cardiovascular health, particularly in the treatment and prevention of conditions such as congestive heart failure, hypertension, and ischemic heart diseases. Research indicates that Co Q10 supplementation can enhance cardiac function, improve ejection fraction and cardiac output, and is beneficial in managing diastolic dysfunction prevalent in various cardiac conditions. Furthermore, studies have shown that Co Q10 supplementation leads to reduced blood pressure by affecting catecholamine levels and improving endothelial function. It also mitigates oxidative damage to LDL cholesterol, which is associated with atherosclerosis progression, highlighting its preventative role against heart diseases.
Conclusion
In summary, Coenzyme Q10 is an essential cofactor critical for energy metabolism and cellular protection against oxidative stress, particularly in the cardiovascular system. Its supplementation has shown significant promise in improving cardiac health and function, offering benefits in the treatment of various heart-related diseases while also demonstrating potential in addressing other health issues like cancer and neurodegenerative disorders. Given its vital role in several metabolic processes and its therapeutic applications, increased attention to Co Q10 supplementation could serve as a preventive measure against numerous severe diseases, emphasizing its importance in maintaining overall health and wellness.
FAQ section (important questions/answers):
What is Coenzyme Q10 and its primary function in the body?
Coenzyme Q10, or Ubiquinone, is a vitamin-like substance essential for energy production in cells. It acts as a cofactor for mitochondrial enzymes involved in oxidative phosphorylation, helping convert food into energy, particularly in high metabolic demand tissues like the heart.
How does Coenzyme Q10 benefit cardiovascular health?
Coenzyme Q10 supplementation has shown significant benefits in managing various cardiovascular diseases, including congestive heart failure, hypertension, and ischemic heart diseases. It improves vital cardiac parameters and may reduce blood pressure by lowering catecholamine levels.
Can Coenzyme Q10 improve recovery after cardiac surgery?
Yes, preoperative administration of Coenzyme Q10 has been associated with improved postoperative recovery in cardiac surgeries. It reduces low cardiac output incidence, enhances left ventricular function, and decreases oxidative damage markers during recovery.
What are the potential effects of Coenzyme Q10 on cancer?
Preliminary studies suggest Coenzyme Q10 may suppress cancer cell proliferation and enhance factors that kill cancer cells. It has been noted to improve mitochondrial concentrations in the brain, indicating potential neuroprotective effects, particularly in neurodegenerative diseases.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淐oenzyme q 10 : a review鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Medicine:
Medicine is the field that focuses on the diagnosis, treatment, and prevention of diseases and health conditions. It encompasses various disciplines, including pharmacology, which studies drug interactions, and preventive measures against diseases, such as cardiovascular complications, as well as the potential effects of supplementation with substances like Coenzyme Q10.
2) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth and division. The text highlights the role of Coenzyme Q10 in potentially suppressing cancer cell proliferation, suggesting a therapeutic avenue for cancer treatment. This relevance addresses the ongoing search for adjunct therapies in the medical community.
3) Post:
In a medical context, 'post' often precedes 'operative' or 'surgical,' relating to the recovery phase following medical procedures. The document discusses how Coenzyme Q10 supplementation can enhance recovery post-cardiac surgeries, indicating its importance in minimizing complications and improving outcomes during this critical phase of patient care.
4) Pharmacology:
Pharmacology is the branch of medicine concerned with the study of drugs and their effects on biological systems. It is central to understanding how Coenzyme Q10 acts within the body, its pharmacokinetics, and its clinical applications in treating cardiovascular and other conditions, highlighting the intersection of chemistry and health.
5) Substance:
A substance is any material with a defined composition and properties. In this context, Coenzyme Q10 is described as a vitamin-like substance essential for mitochondrial function and energy production, showcasing its vital role in health and disease management, particularly in preventing cardiovascular diseases.
6) Science (Scientific):
Science refers to the systematic study of the nature and behavior of the physical and natural world. The article presents Coenzyme Q10 as a subject of scientific inquiry, discussing its biochemical role in cellular metabolism and the underlying mechanisms that could lead to clinical advancements in healthcare.
7) Blood:
Blood is the bodily fluid responsible for transporting nutrients, oxygen, and waste products through the circulatory system. The text notes how Coenzyme Q10 impacts blood levels of catecholamines, which can lower blood pressure, emphasizing its significance in managing blood-related conditions, particularly hypertension.
8) Activity:
Activity in a medical sense often refers to the measurement of the effect or efficacy of a treatment. The document illustrates that Coenzyme Q10 can improve cardiac activity during various cardiac diseases, contributing to enhanced exercise capacity and daily functioning, stressing the importance of metabolic efficiency.
9) Drug:
A drug is any substance that causes a change in the biological processes of the body. Coenzyme Q10 acts effectively in the capacity of a therapeutic agent, being used in formulations to combat cardiovascular diseases and potentially in oncology, illustrating its relevance as a medicinal drug.
10) Ramanatha (R膩man膩tha, Ram膩n膩tha, Ramnath, Rama-natha):
Ram-nath could refer to the specific publisher, Kedar Nath Ram Nath & Co., noted within the literature. The significance of the mention underscores the dissemination of medical knowledge through established publisher networks, contributing to the accessibility and credibility of research findings, such as those regarding Coenzyme Q10.
11) Vadhana (V膩岣峢a峁嘺, Vadhan膩, V膩dhana, V膩dhan膩):
Vadhana is part of the authors or contributors in the referenced studies. How each collaborator contributes to the broader discourse on substances like Coenzyme Q10 helps in solidifying the interdisciplinary basis of the research, emphasizing collaboration's importance in achieving a comprehensive understanding of medical advancements.
12) Nava (N膩v膩, N膩va, Nav膩, Navan):
Although 'Nava' is not explicitly defined in the document, it could refer to scientific contributions or publications relevant to the study context. Its relevance in the ongoing research highlights the importance of collective scholarly efforts in the advancement of medical understanding and the role of antioxidants like Coenzyme Q10.
13) Casha (C膩峁, C膩sa):
Casa may refer to the publisher mentioned, 'Casa Editrice Scientifica Internazionale,' which specializes in disseminating important scientific literature. This aspect is vital for academics and practitioners in medicine as it underlines the impact of reputable publishing in the dissemination of crucial medical research findings and guidelines.
14) Kubo:
Kubo might refer to an author or study context related to Coenzyme Q10. The significance of authorial contributions or studies underscores the importance of peer-reviewed literature in informing clinical practices and guiding therapeutic decisions in managing diseases such as hypertension and heart disease.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Coenzyme q 10 : a review鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Cardiovascular disease, Ischemic Heart Disease, Congestive Heart Failure, Neurodegenerative disease, Oxidative phosphorylation, Free radical-induced damage, Cardiac muscle cell, Coenzyme Q 10, Clinical indication, LDL cholesterol oxidation.