Significance of Nicotinamide
Nicotinamide is a water-soluble vitamin from the B group, playing a significant role in reducing oxidative stress and enhancing insulin release. It is particularly noted for its potential in treating type 1 diabetes, where it promotes beta-cell regeneration and prevents nitric oxide release. Additionally, Nicotinamide, also known as Niacin, helps maintain insulin function in diabetes patients and is utilized in experimental models, particularly when combined with streptozotocin to protect pancreatic cells from damage.
Synonyms: Niacinamide, Vitamin b3
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The concept of Nicotinamide in scientific sources
Nicotinamide, a form of Vitamin B3, is utilized with streptozotocin in diabetic model creation. It is believed to offer protection to pancreatic cells from damage, highlighting its therapeutic potential in diabetes research.
From: The Malaysian Journal of Medical Sciences
(1) This substance was used in combination with streptozotocin to induce micronuclei formation in the experimental setup involving rats.[1] (2) Nicotinamide is a water-soluble vitamin, a niacin derivative, that plays a role in energy production, has antioxidant and antiapoptotic effects, and is involved in signal transduction. It is used for inducing type 2 diabetes in animals and protects B-cells from injury.[2] (3) Nicotinamide is a water-soluble vitamin from the B group that has several roles such as reducing oxidative stress, enhancing insulin release, promoting beta-cell regeneration, and preventing nitric oxide release, and is utilized for treating type 1 diabetes in experimental models.[3]