Significance of Extended Spectrum Beta-Lactamase
Extended Spectrum Beta-Lactamases (ESBLs) are enzymes produced by certain bacteria that confer resistance to a broad range of beta-lactam antibiotics, especially third-generation cephalosporins. These enzymes complicate the treatment of infections, particularly those caused by gram-negative bacteria, as they make commonly used antibiotics less effective. ESBLs contribute to increased challenges in medical treatment and raise concerns regarding treatment outcomes, particularly in cases such as urinary tract infections.
Synonyms: Esbl, Antibiotic resistance, Beta-lactamase enzyme, Multidrug resistance
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The concept of Extended Spectrum Beta-Lactamase in scientific sources
Extended Spectrum Beta-Lactamase (ESBL) enzymes are produced by specific bacteria, granting resistance to various antibiotics, especially penicillins and third-generation cephalosporins, complicating infection treatment and increasing public health concerns.
From: The Malaysian Journal of Medical Sciences
(1) These are discussed in terms of their characterization, epidemiology, and detection, which are all key aspects in understanding and controlling their spread and impact on human health.[1] (2) Extended-spectrum beta-lactamase (ESBL) production was tested for in the recovered Gram-negative bacteria, with the result showing no ESBL production.[2] (3) Often abbreviated as ESBL, this refers to a type of enzyme produced by bacteria, making them resistant to certain antibiotics, and it was found in cases of Klebsiella pneumoniae and Escherichia coli.[3] (4) Enzymes produced by certain bacteria that provide resistance to a wide range of beta-lactam antibiotics by hydrolyzing them.[4] (5) A group of enzymes produced by some bacteria that confer resistance to a wide range of beta-lactam antibiotics.[5]