pH Influence on Stavudine Release from Hydroxypropyl Methyl Cellulose Matrices
Journal name: World Journal of Pharmaceutical Research
Original article title: The influence of ph on drug release from stavudine hydrophilic matrices containing different grades of hydroxypropyl methyl cellulose
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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Masheer Ahmed Khan
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: The influence of ph on drug release from stavudine hydrophilic matrices containing different grades of hydroxypropyl methyl cellulose
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Stavudine, a thymidine analog approved by the US-FDA for treating HIV infection, experiences an enhanced therapeutic effect when given in a sustained release formulation. This study delves into how varying pH levels affect the drug release from hydrophilic matrices composed of different grades of hydroxypropyl methylcellulose (HPMC).
Preparation and Characterization of Hydrophilic Matrices
The hydrophilic matrices of stavudine were prepared using combinations of HPMCK4M and HPMCK15M, two grades of HPMC. Tablets underwent physical characterization to measure parameters like hardness, friability, and weight variation, all of which were found to be within acceptable limits.
Multimedia Dissolution Studies
The study involved evaluating drug release in different pH environments�2.4, 6.8, and 7.4—using a USP dissolution apparatus at 37°C and 50 rpm. The release of stavudine was monitored using UV spectrophotometry at 266 nm, with samples taken at multiple intervals over a 12-hour period. Results indicated that drug release was significantly affected by the pH levels of the dissolution media.
Impact of pH on Drug Release
The percentage of drug release from the matrices increased continuously over time, with the highest cumulative release observed in the most alkaline medium (pH 7.4). This trend suggests that stavudine’s solubility, and thus its release, is pH-dependent, increasing significantly in more alkaline conditions.
Conclusion
The study concludes that the release profile of stavudine from hydrophilic matrices is profoundly influenced by pH levels, with the highest release rates at pH 7.4. This pH-dependent solubility enhances the drug’s release from matrices, providing insights for optimizing sustained release formulations of antiretroviral therapies.
FAQ section (important questions/answers):
What is the objective of this study?
The study examines the effect of multimedia dissolution profile on drug release from hydrophilic matrices of stavudine using different grades of hydroxypropyl methylcellulose (HPMC).
What is stavudine used for?
Stavudine is a thymidine analog approved by the US-FDA for treating HIV infections, particularly for patients intolerant to or who failed other antiretroviral therapies.
How were the hydrophilic matrices prepared?
Tablets were prepared by direct compression using combinations of HPMCK4M and HPMCK15M polymers, along with other excipients like magnesium stearate, talc, and MCC.
How was the drug release tested?
The drug release was tested in phosphate buffer with pH 2.4, 6.8, and 7.4 using the USP dissolution apparatus set at 50 rpm and 37°C. Absorbance was measured at different time intervals up to 12 hours.
How does pH affect drug release from stavudine matrices?
The drug release increases with pH. It is highest at pH 7.4, followed by pH 6.8 and pH 2.4. This is attributed to stavudine's pH-dependent solubility.
What were the findings related to stavudine's release profile?
The stavudine release profile from the matrices shows a continuous increase over time, with the greatest cumulative release observed at pH 7.4, indicating higher solubility and release in more alkaline conditions.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “pH Influence on Stavudine Release from Hydroxypropyl Methyl Cellulose Matrices�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
In this context, a drug refers to a pharmaceutical compound used for medical treatment, specifically stavudine, which is highlighted in the study. Stavudine is an antiretroviral drug approved by the US-FDA for treating HIV infections. This research focuses on its controlled release from hydrophilic matrices in various pH conditions.
2) Substance:
The term 'substance' here pertains to the active pharmaceutical ingredient (API), stavudine, being studied. It indicates the material subject to analysis, particularly how the sustained release matrices behave and affect stavudine's dissolution and absorption under different pH conditions relevant to its in-vivo journey.
3) Devi (Devī):
This word is part of the name 'Devi Ahilya Vishwavidyalaya', the academic institution associated with the author of this study, Dr. Masheer Ahmed Khan. It provides institutional affiliation, lending credibility and context to the research published in the World Journal of Pharmaceutical Research.
4) Discussion:
Discussion: This section examines and analyzes the data obtained from experimental results. It involves interpreting the findings from the dissolution studies, comparing drug release profiles at varying pH levels, and understanding the implications for stavudine's sustained release formulation. This critical examination helps draw conclusions on drug efficacy and performance.
Other Science Concepts:
Discover the significance of concepts within the article: �pH Influence on Stavudine Release from Hydroxypropyl Methyl Cellulose Matrices�. Further sources in the context of Science might help you critically compare this page with similair documents:
Therapeutic effect, Adverse effect, Sustained release, Pharmacodynamics and Pharmacokinetics, Absorbance measurement, UV Spectrophotometer, Phosphate buffer, Elimination half life.