Significance of Elimination half life
Elimination half life refers to the time required for the plasma concentration of a drug to reduce to half its original value. This measure is essential for understanding drug action duration, effective dosing intervals, and persistence in the body. For example, the elimination half life of levofloxacin is 3.502 hours, while Ramipril ranges from 9 to 18 hours. The concept is key in pharmacology as it helps gauge how long a drug remains effective in the bloodstream and informs dosing regimens.
Synonyms: Biological half-life, Pharmacokinetic half-life
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The concept of Elimination half life in scientific sources
Elimination half-life is the duration needed for a drug's concentration in the blood, such as Ramipril, enrofloxacin, or diclofenac, to decrease by half, impacting its effectiveness and duration of action, typically ranging from 9 to 18 hours.
From: The Malaysian Journal of Medical Sciences
(1) The elimination half-life of the drug was measured, to determine how long the drug remains in the body, and whether this changes between single and multiple doses.[1]