Anorthosite: Anti-Cancer Approach for H460 Lung Cancer via ROS Analysis
Journal name: Ayushdhara
Original article title: Anorthosite (Lunar Rock Replicant) - An Anti-Cancerous Medicinal Approach for H460: Human Lung Cancer with Validation via ROS Anti-Oxidant Analysis
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Yamini Malhotra
Research Scholar, Dept of Earth Sciences, Annamalai University, Tamil Nadu, India.
SR Singara Subramanian
Professor & Former Head, Dept of Earth Sciences, Annamalai University, Tamil Nadu, India.
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: Anorthosite (Lunar Rock Replicant) - An Anti-Cancerous Medicinal Approach for H460: Human Lung Cancer with Validation via ROS Anti-Oxidant Analysis
Year: 2023 | Doi: 10.47070/ayushdhara.v10i5.1319
Copyright (license): CC BY-NC-SA 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Anorthosite, a mineral found in lunar regolith, presents promising applications in cancer therapy and space medicine. This study explores the anti-cancer properties of anorthosite nanoparticles synthesized from samples collected in Salem, Tamil Nadu, India. By assessing their cytotoxic effects on H 460 lung cancer cells, the researchers aimed to investigate the potential of anorthosite as a novel treatment modality for lung cancer. The research involved comprehensive testing using the MTT assay and included evaluations of the nanoparticles' ability to mitigate oxidative stress, which is especially pertinent to astronaut health during prolonged space missions.
Cytotoxic Effects on H 460 Lung Cancer Cells
The research revealed a dose-dependent cytotoxic effect of anorthosite nanoparticles on H 460 lung cancer cells, signified by an IC 50 value of 21.65. This figure indicates a considerable level of toxicity, suggesting that anorthosite could be utilized in various cancer treatment methodologies, including chemotherapy and targeted therapies. The study employed MTT assays, which demonstrated that higher concentrations of anorthosite led to more significant reductions in cell viability. The findings underscore the significance of further investigations into the precise mechanisms of anorthosite-induced cytotoxicity, as well as its potential therapeutic applications in vivo.
Antioxidant Properties for Space Medicine
In addition to its anti-cancer properties, the research evaluated anorthosite nanoparticles for their antioxidant potential. Given that astronauts are exposed to increased oxidative stress due to cosmic radiation, the ability of anorthosite to scavenge reactive oxygen species (ROS) is critically important for safeguarding their health during space missions. The results indicated that anorthosite nanoparticles possess strong antioxidant properties, presenting a dual application where they could protect astronauts from the damaging effects of radiation while also serving as an anti-cancer agent. These findings point towards the broad potential applications of anorthosite beyond mere geological interest.
Conclusion
The study concludes that anorthosite nanoparticles represent a viable candidate for cancer treatment through their demonstrated cytotoxic effects on lung cancer cells and their antioxidant capabilities in the context of space travel. With the potential to serve as a dual-purpose agent for both anti-cancer therapy and the protection of astronauts from oxidative stress, anorthosite opens new avenues for research in medicinal applications. The findings advocate for continued exploration into the therapeutic potential of anorthosite, emphasizing its role as an innovative material in both medical and space contexts.
FAQ section (important questions/answers):
What is the primary application of anorthosite in cancer therapy?
Anorthosite nanoparticles were synthesized to treat H 460 lung cancer cells. They showed a dose-dependent cytotoxic effect, indicating potential as a novel treatment modality based on their IC 50 value of 21.65.
How does anorthosite help astronauts during space missions?
Anorthosite nanoparticles possess potent antioxidant properties, which can scavenge reactive oxygen species (ROS). This capability is crucial for mitigating oxidative stress that astronauts face during prolonged space travel.
What methods were used to assess the effects of anorthosite?
The effects of anorthosite were evaluated using MTT assays for cytotoxicity and ROS analysis. FTIR spectroscopy was also conducted to identify functional groups present, aiding in the understanding of its medicinal properties.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anorthosite: Anti-Cancer Approach for H460 Lung Cancer via ROS Analysis�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Cancer:
The primary focus of the study is on the potential of anorthosite nanoparticles as a treatment modality for lung cancer, specifically targeting H 460 human lung cancer cells. The research emphasizes the compound's cytotoxic effects and its viability as an anti-cancer agent. [Cancer]
2) India:
The research was conducted in India, with sources indicating involvement from institutions such as Annamalai University in Tamil Nadu and additional support from Tri-Biotech Research Lab in Trichy. The study also gathered natural samples from Salem, a city in Tamil Nadu. [India]
3) Death:
One of the significant findings was the induction of cell death in H 460 lung cancer cells upon exposure to anorthosite-treated samples. The cytotoxic effects were confirmed through MTT assays and ROS anti-oxidant analyses, showing high levels of cell death. [Death]
4) Drug:
Anorthosite was explored for its potential as a drug to treat lung cancer. Various assays demonstrated its high toxicity against cancer cells, making it a candidate for further drug development in cancer therapy. The study also suggested its utility for astronauts. [Drug]
5) Singara (Simgara):
SR Singara Subramanian is one of the authors and serves as a Professor and Former Head, Dept of Earth Sciences, Annamalai University, Tamil Nadu, India. He contributed significantly to this study by co-authoring the research. [Singara]
6) Yamini:
Yamini Malhotra, also an author and a research scholar at Annamalai University, Tamil Nadu, India, co-conducted the study. She has been recognized with awards like the Women Icon Asia Technology Award and Woman Ph.D. Scholar Award. [Yamini]
7) Toxicity:
The study emphasizes the high toxicity of anorthosite nanoparticles against H 460 lung cancer cells, with an IC 50 value of 21.65, signifying its strong cytotoxic potential. This makes it a promising candidate for use in cancer therapies. [Toxicity]
8) Medicine:
The research highlights anorthosite as a potential new form of nano-medicine, capable of treating lung cancer and possibly other diseases. The study also mentions its use in space medicine for safeguarding astronauts from oxidative stress. [Medicine]
9) Shalem (Salem):
Salem, a city in Tamil Nadu, India, was the source of the anorthosite samples used in the study. The collected samples were essential for conducting the MTT assays and other analyses to test their anti-cancer properties. [Salem]
10) Cow urine (Cow's urine):
In the study, cow urine was used as one of the solvents to isolate and extract bioactive compounds from anorthosite, highlighting its role in traditional and alternative medicinal practices.
11) Tamilnadu (Tamil-nadu):
Tamil Nadu is the Indian state where the study was conducted, with samples collected from Salem and various experiments performed at Annamalai University and Tri-Biotech Research Lab in Trichy. [Tamil-nadu]
12) Indian:
The research has strong Indian ties, with institutions and resources like Annamalai University, Indian Space Research Organisation, and Survey of India playing crucial roles.
13) Tamil:
The study is deeply connected to the Tamil region of India, with Tamil Nadu being the primary state involved. Salem, a city in Tamil Nadu, provided the natural anorthosite samples for research. [Tamil]
14) Nadu:
Short for Tamil Nadu, a state in India, which is integral to this research. The studies were primarily conducted in research institutes located in this state, including Annamalai University in Tamil Nadu. [Nadu]
15) Phytochemical:
The study discusses the presence of bioactive phytochemicals in anorthosite, which contribute to its anti-cancer properties. These compounds showed significant toxicity against lung cancer cells in MTT assays and ROS analyses.
16) Earth:
Anorthosite, typically found on Earth, was collected for this study to analyze its potential medical applications. It’s also noted for its abundance on the Moon, suggesting extraterrestrial applications. [Earth]
17) Eagle:
'Dulbecco’s Modified Eagle Medium (DMEM)' was used in cell culture procedures to cultivate human lung cancer cells H 460. This medium provides essential nutrients to support cell growth. [Eagle]
18) New Delhi:
The corresponding author of the study presented findings at the Indian Cancer Congress in 2013, held in New Delhi, reflecting the research's recognition and dissemination within significant scientific forums. [New Delhi]
19) Discussion:
The discussion section of the study elaborates on the experimental design, anti-cancer properties, and potential applications of anorthosite. It also reflects on the implications of findings in cancer treatment and space medicine. [Discussion]
20) Science (Scientific):
The article published in AYUSHDHARA follows scientific rigor, employing assays like MTT and ROS analysis, and tools like FTIR spectroscopy. The findings support new scientific avenues in cancer therapy and space medicine. [Scientific]
21) Annamalai:
Annamalai University in Tamil Nadu, India, served as the primary research base for this study. Both authors are associated with this institution, which facilitated the various scientific procedures. [Annamalai]
22) Disease:
The focus of the research is on lung cancer, a devastating disease. The study explores the potential of anorthosite nanoparticles as a treatment for this disease, with promising cytotoxicity results. [Disease]
23) Mineral:
Anorthosite, a mineral found both on Earth and the Moon, is highlighted in the study for its dual applications in cancer therapy and space medicine. Its composition includes aluminum, calcium, and silicon. [Mineral]
24) Trichy:
The Tri-Biotech Research Lab, located in Trichy, Tamil Nadu, was instrumental in conducting essential tests and analyses, providing support for some experiments under a payable facility arrangement. [Trichy]
25) Delhi:
Presentations of the research have been made in various scientific forums, including in New Delhi, reinforcing the dissemination of findings within the scientific community.
26) Ayus (Ayush):
AYUSHDHARA is the journal where this research was published. It specializes in research related to AYUSH (Ayurveda, Yoga & Naturopathy, Unani, Siddha, and Homeopathy) and allied systems. [Ayush]
27) Pune:
The human lung cancer cell line H 460 used in this study was sourced from NCCS (National Centre for Cell Science) in Pune, India, indicating the collaborative effort involved in the research. [Pune]
Other Science Concepts:
Discover the significance of concepts within the article: �Anorthosite: Anti-Cancer Approach for H460 Lung Cancer via ROS Analysis�. Further sources in the context of Science might help you critically compare this page with similair documents:
Oxidative stress, Nano medicine, Reactive oxygen species, Therapeutic potential, Apoptosis, MTT assay, Cell culture, Anti-cancerous properties, Cell viability, Fourier transform infrared spectroscopy, DMSO, In vitro model, Fetal bovine serum, Cell death.