Analysis of Modified Dosage Forms of Gojihwadi Kwatha
Journal name: Ayushdhara
Original article title: Pharmaceutico - Analytical Evaluation of Modified Dosage Forms of Gojihwadi Kwatha
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Deepak Kumar Sharma
Medical Officer, Dept. of AYUSH, Rajasthan Government, Rajasthan, India.
Priyanka Sharma
Associate Professor, Dept. of Ras shastra and Bhaishajya Kalpana, MJF Ayurveda Mahavidhalaya, Harota, Jaipur, Rajasthan, India.
Rajendra Kumar Sharma
Professor, Dept. of Ras shastra and Bhaishajya Kalpana, NIA, Deemed to be University, Jaipur, Rajasthan, India.
Shobnath Yadav
Pharmacy Manager, Dept. of Ras shastra and Bhaishajya Kalpana, NIA, Deemed to be University, Jaipur, Rajasthan, India.
Vijay Shankar Verma
MD Scholar, Dept. of Ras shastra and Bhaishajya Kalpana, NIA, Deemed to beUniversity, Jaipur, Rajasthan, India
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: Pharmaceutico - Analytical Evaluation of Modified Dosage Forms of Gojihwadi Kwatha
Year: 2023 | Doi: 10.47070/ayushdhara.v10i3.1261
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Introduction
Coughing, termed as "Kasa" in Ayurveda, is a prevalent health issue leading many individuals to seek medical intervention, particularly due to its association with bronchitis and respiratory infections. Traditional Ayurvedic practices offer remedies to alleviate such conditions, with Gojihwadi Kwatha being a notable formulation developed by the eminent physician Yadavji Trikamji Acharya. This study aims to evaluate and standardize modified dosage forms of Gojihwadi Kwatha, specifically its syrup, granules, and powdered form (churna), focusing on their safety and efficacy in treating respiratory ailments.
Pharmacological Properties of Gojihwadi Kwatha
Gojihwadi Kwatha is recognized for its therapeutic properties in managing respiratory issues as it contains a blend of Ayurvedic and Unani ingredients, acting as bronchodilators, mucolytics, and expectorants. Among its 16 components are Draksha (Vitis vinifera), Yashtimadhu (Glycyrrhiza glabra), and Vasa (Adathoda vasica), which contribute significantly to its effectiveness. The study highlights the preparation process of this formulation, emphasizing the significance of organoleptic and physiochemical parameters such as taste, color, viscosity, and pH, which are essential in determining the quality and safety of medicinal preparations.
Analytical Evaluation of Modified Dosage Forms
The analytical assessment conducted on the modified dosage forms—Gojihwadi syrup, granules, and churna—was crucial in establishing their safety profiles. The results indicated that all preparations met standard specifications with no pathogens detected, demonstrating their microbiological safety. The syrup exhibited a viscosity of 34.62 cP, total sugar content of 85.07%, and indicated a favorable pH of 6.0, confirming its compatibility as a therapeutic agent. Similarly, the granules showed a satisfactory total sugar content of 78.44% and were devoid of harmful microbial presence, reinforcing their viability for consumption.
Conclusion
This study successfully demonstrates that the modified dosage forms of Gojihwadi Kwatha, including syrup and granules, maintain the traditional efficacy of the original formulation while ensuring safety through thorough analytical evaluations. With the preparation of 12 kg of churna, 6 liters of syrup, and 3 kg of granules, the results affirm their potential as effective remedies for respiratory issues, warranting further research and clinical application of these formulations in contemporary Ayurvedic practice.
FAQ section (important questions/answers):
What is the purpose of Gojihwadi Kwatha in Ayurveda?
Gojihwadi Kwatha is an Ayurvedic formulation used to treat respiratory issues such as cough and bronchitis. It acts as a bronchodilator, mucolytic, and expectorant, helping to relieve thick and adhesive sputum associated with respiratory infections.
How are the modified forms of Gojihwadi prepared?
The modified forms of Gojihwadi include syrup, granules, and churna. These are prepared by soaking the coarse powder, boiling it until reduced, and then combining with sugar, ensuring the formulations adhere to standardized operating procedures.
What safety measures are in place for Gojihwadi products?
All modified Gojihwadi products undergo extensive analysis for microbial counts, sugar content, and pesticide residues. The study confirms the absence of specific pathogens, ensuring that the formulations are safe for consumption.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Analysis of Modified Dosage Forms of Gojihwadi Kwatha�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Sugar:
Sugar content in Gojihwadi syrup is crucial for its sweet taste and shelf stability. During preparation, 5.6 kg of sugar was added. This increased the viscosity and non-reducing sugar content to 83.65% and reducing sugar content to 1.42%.
2) Powder:
Gojihwadi Kwatha Churna is a coarse powder used as the primary form in the preparation of various dosage forms, including syrup and granules. The powder form aids in better extraction and dissolution of active compounds.
3) Jaipur:
The study on Gojihwadi Kwatha and its modified forms was conducted in Jaipur at the National Institute of Ayurveda. The pharmaceutical processes and analytical evaluations took place in various departments within this institute in Jaipur.
4) Sharman (Sarma, Sharma, Sarman):
Multiple authors with the surname Sharma contributed to the research and preparation of the paper, including Deepak Kumar Sharma, who is a Medical Officer in the Dept. of AYUSH in Rajasthan. The surname is prevalent among the contributors.
5) Drug:
The Gojihwadi Kwatha formulation includes various Ayurvedic and Unani drugs such as Draksha, Yashtimadhu, and Kantakari, which possess pharmacological properties like bronchodilation and mucolytic action. These drugs are combined to treat respiratory conditions.
6) Bhaishajya (Bhaisajya):
Bhaishajya Kalpana is a department involved in the standardization and preparation of Ayurvedic medicines, such as the Gojihwadi Kwatha syrup and granules. It emphasizes processes, including Shodhana, and pharmaceutical techniques.
7) Shastra (Sastra):
Rasa Shastra, paired with Bhaishajya Kalpana, involves the preparation and standardization of Ayurvedic medicines. These traditional sciences guide the formulation and analytical evaluation of products like Gojihwadi Kwatha.
8) Kalpana:
[see source text or glossary: Kalpana]
9) Cotton:
Clean cotton cloth was used to filter the Gojihwadi Kwatha during the preparation process. This ensures the removal of unwanted particulate matter, yielding a clean final product.
10) Kumar:
Deepak Kumar Sharma is one of the primary researchers involved in the study, responsible for the medicinal evaluation and preparation processes of Gojihwadi Kwatha in this pioneering research.
11) Rajasthan:
The research was conducted by professionals from the Dept. of AYUSH in Rajasthan and NIA Jaipur, focusing on Ayurvedic formulations pertinent to the region's health practices.
12) Mandagni (Manda-agni, Mamdagni):
Mandagni, which refers to a low flame or gentle heat, was used in boiling the Gojihwadi Kwatha to ensure proper extraction without damaging the therapeutic ingredients.
13) Draksha (Draksa):
Draksha, scientifically known as Vitis vinifera, is a crucial ingredient in Ayurvedic formulations like Gojihwadi Kwatha. It serves as a bronchodilator and expectorant, aiding in the treatment of respiratory conditions.
14) Disease:
The study sought to address 'Kasa' (cough), a common respiratory disease described in Ayurvedic classics, which corresponds to modern bronchitis. The effectiveness of Gojihwadi Kwatha was evaluated against pathogens causing respiratory tract infections.
15) Dravya:
[see source text or glossary: Dravya]
16) Aureus:
One of the key microbiological tests included in the analysis confirmed the absence of specific pathogens such as Staphylococcus aureus in Gojihwadi Kwatha, syrup, and granules, ensuring their safety.
17) Ayurveda (Ayus-veda):
Ayurveda, the ancient Indian system of medicine, forms the foundation for the preparation and evaluation of Gojihwadi Kwatha. This traditional system aims to treat diseases like 'Kasa' through natural formulations.
18) Rasa (Rasha):
Rasa Shastra is a branch of Ayurveda focusing on pharmaceutical processes of medicine preparation, including the Gojihwadi Kwatha. This involves detailed methods and standards to make effective Ayurvedic remedies.
19) Kasa (Kasha):
Kasa, or cough, is a term in Ayurveda that matches the symptoms and pathophysiology of bronchitis. The study aimed to utilize Gojihwadi Kwatha to treat Kasa, addressing cough through Ayurvedic remedies.
20) Rasashastra (Rasa-shastra, Rasasastra):
Rasa-shastra encompasses the ancient alchemical and pharmaceutical techniques of Ayurveda involving the preparation and standardization of therapeutic formulations such as Gojihwadi Kwatha.
21) Prakshepa (Praksepa):
Prakshepa dravya refers to the fine powdered ingredients added during the preparation of Gojihwadi granules to achieve the desired consistency and therapeutic effect.
22) Pesticide:
Analytical tests showed that Gojihwadi Kwatha syrup had pesticide residue values within the standard parameters, ensuring the safety and purity of the product for consumption.
23) Yoga:
[see source text or glossary: Yoga]
24) Kantakari (Kamtakari):
Kantakari, scientifically known as Solanum xanthocarpum, is one of the Ayurvedic herbs used in Gojihwadi Kwatha. It aids in treating respiratory conditions through its mucolytic and bronchodilating properties.
25) Kapha:
According to Ayurveda, Kaphaj Kasa results from an imbalance of the Kapha dosha, caused by factors like dietary excesses. Gojihwadi Kwatha aims to restore this balance and treat the associated symptoms.
26) India:
The research on Gojihwadi Kwatha was conducted in India, specifically Jaipur, reflecting India's rich tradition in Ayurvedic medicine. The study follows ancient Indian medicinal practices to provide modern therapeutics.
27) Ayus (Ayush):
The AYUSH department of Rajasthan supported the research. AYUSH stands for Ayurveda, Yoga & Naturopathy, Unani, Siddha, and Homoeopathy, emphasizing India's traditional medicinal systems.
28) Vasa (Vasha):
Vasa, or Adathoda vasaca, is an ingredient used in Gojihwadi Kwatha known for its efficacy in treating bronchitis and other respiratory ailments through its anti-inflammatory properties.
29) Food:
Modern dietary habits like the consumption of fast and junk food contribute to the vitiation of Kapha, Pitta, and Vata doshas, leading to diseases such as Kasa (cough). Gojihwadi Kwatha addresses these imbalances.
30) Fire:
Fire, termed as Mandagni in Ayurveda, is used to carefully heat and prepare the Gojihwadi Kwatha, ensuring efficient extraction of active compounds without degrading them.
31) Solanum xanthocarpum:
Solanum xanthocarpum, or Kantakari, is a herbal ingredient in Gojihwadi Kwatha that helps in treating respiratory problems due to its mucolytic and expectorant properties.
32) Cow urine (Cow's urine):
Acharya Charaka describes boiling medicinal plants in vessels with cow urine diluted with water to enhance the extraction process during Kwatha preparation.
33) Cordia dichotoma:
Cordia dichotoma, known as Sleshmatak, is an ingredient in Gojihwadi Kwatha used for its therapeutic properties in treating respiratory conditions.
34) Pharmacological:
Pharmacological properties of ingredients like Draksha and Yashtimadhu in Gojihwadi Kwatha include bronchodilation, mucolysis, and expectoration, making them effective in respiratory treatments.
35) Vitis vinifera:
Vitis vinifera, or Draksha, is a key ingredient in Gojihwadi Kwatha known for its bronchodilator and expectorant properties, aiding in the relief of respiratory conditions.
36) Yogasamgraha (Yogasangraha, Yoga-samgraha, Yoga-sangraha):
Gojihwadi Kwatha is mentioned in the 20th-century Ayurvedic text ‘Siddhayoga Sangraha� by Yadavji Trikamji, underscoring its traditional and historical use in treating ailments like Kasa.
37) Inflammation:
Bronchitis, involving the inflammation of the bronchi, is one of the conditions targeted by Gojihwadi Kwatha, reducing inflammation and aiding in respiratory health.
38) Yashtimadhu (Yastimadhu, Yashti-madhu):
Yashtimadhu, or Glycyrrhiza glabra, is an ingredient in Gojihwadi Kwatha that helps soothe the respiratory tract and act as an expectorant in cough treatments.
39) Pratishyaya (Pratisyaya):
Gojihwadi Kwatha is indicated for Pratishyaya, which includes conditions like common cold and sinusitis, suggesting its use in treating upper respiratory tract inflammations and infections.
40) Abhishyanda (Abhisyanda):
One of the causes for Kaphaj Kasa includes excess consumption of Abhishyanda, leading to the accumulation and vitiation of Kapha dosha, which Gojihwadi Kwatha aims to balance.
41) Discussion:
The discussion in the research explains the significance of each component and the overall efficacy of Gojihwadi Kwatha in treating Kasa (cough) through Ayurvedic principles and pharmacological properties.
42) Substance:
[see source text or glossary: Substance]
43) Shodhana (Sodhana):
The process of Shodhana, or purification, is fundamental in removing foreign matter from raw materials used in Gojihwadi Kwatha, enhancing their safety and efficacy.
44) Mishreya (Misreya):
[see source text or glossary: Mishreya]
45) Medicine:
Ayurvedic medicine Gojihwadi Kwatha incorporates ancient formulations of herbs and other ingredients to treat conditions like Kasa, and is analyzed for efficacy and safety.
46) Samgraha (Sangraha):
Siddhayoga Sangraha is the text in which Gojihwadi Kwatha is described, guiding its preparation and therapeutic applications in Ayurvedic medicine.
47) Madhura:
An excess consumption of Madhura (sweet) foods is one of the factors causing Kaphaj Kasa, indicating the therapeutic need for formulations like Gojihwadi Kwatha in balancing Kapha dosha.
48) Samhita:
[see source text or glossary: Samhita]
49) Sparsha (Sparsa):
[see source text or glossary: Sparsha]
50) Snigdha:
Snigdha, meaning oily or unctuous foods, contribute to the imbalance of Kapha dosha. Gojihwadi Kwatha helps balance this dosha, addressing conditions like Kaphaj Kasa.
51) Siddha:
[see source text or glossary: Siddha]
52) Vaidya:
The famous Vaidya Yadavji Trikamji Acharya designed the Gojihwadi Kwatha. Vaidya translates to physician in English, reflecting his expertise in Ayurvedic formulations.
53) Sthana:
Charaka discusses the preparation methods of Kwatha in Viman Sthana, emphasizing proper examination and processing of the ingredients to ensure the efficacy of formulations like Gojihwadi Kwatha.
54) Gandha (Gamdha):
[see source text or glossary: Gandha]
55) Nidana:
Nidana, the causative factors, of diseases like Kasa are classified as exogenous and endogenous and are considered pivotal in Ayurvedic diagnostics and treatment planning.
56) Nature:
The nature of the plant components in Gojihwadi Kwatha, such as adhesive and thickening characteristics, influences the formulation's viscosity and effectiveness against respiratory ailments.
57) Panca (Pancan, Pamca):
The organoleptic evaluation of Gojihwadi Kwatha utilized Pancha gyaanendriya (five sense organs), highlighting the importance of sensory verification in Ayurvedic quality control.
58) Pitta:
Pitta, one of the three doshas in Ayurveda, can be aggravated alongside Kapha in respiratory conditions. Gojihwadi Kwatha aims to balance these doshas to alleviate symptoms like Kasa.
59) Atasi:
Atasi, or Linumus itatissimum, is one of the herbal ingredients in Gojihwadi Kwatha, contributing to its therapeutic properties for treating respiratory ailments.
60) Viman:
[see source text or glossary: Viman]
61) Edema (Oedema):
Edema, or swelling due to fluid accumulation, may occur with respiratory infections. Gojihwadi Kwatha aims to treat such symptoms through its diverse herbal composition.
62) Viti:
[see source text or glossary: Viti]
63) Rupa:
[see source text or glossary: Rupa]
64) Vata:
[see source text or glossary: Vata]
65) Beta:
[see source text or glossary: Beta]
Other Science Concepts:
Discover the significance of concepts within the article: �Analysis of Modified Dosage Forms of Gojihwadi Kwatha�. Further sources in the context of Science might help you critically compare this page with similair documents:
Analytical study, Bronchitis, Kasa (cough), Physico-chemical parameters, Pharmaceutical processes, Organoleptic character, Total sugar content, Kaphaj Kasa, Gojihwadi Kwatha, Nidana of disease, Modified dosage form, Respiratory tract infection.