Efficacy of matra vasti with panchtikta guggulu in osteoarthritis.
Journal name: Ayushdhara
Original article title: Study to evaluate the efficacy of matra vasti of panchtikta guggulu ghrita in sandhivata (osteoarthritis)
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Neetu Sharma
Assistant Professor, Dept. of Kayachikitsa, SSSB Ayurvedic College & Hospital, Renwal, Jaipur.
N.R.Singh
Professor & Head of Department, Dept. of Kayachikitsa, Ch. Brahm Prakash Ayurveda Charak Sansthan, New Delhi.
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: Study to evaluate the efficacy of matra vasti of panchtikta guggulu ghrita in sandhivata (osteoarthritis)
Year: 2021 | Doi: 10.47070/ayushdhara.v8i2.712
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Introduction
The study evaluates the efficacy of Matra Vasti of Panchtikta Guggulu Ghrita in managing Sandhivata, correlating it with osteoarthritis (OA) based on clinical features. Sandhivata, a principal manifestation of Vatapradhana Vyadhi, poses significant therapeutic challenges, particularly in slowing the progression of Dhatu Kshaya and pacifying Vata dosha. OA is characterized by the degeneration of joint cartilage and underlying bone, often leading to pain, stiffness, and reduced function. Given the limitations of modern medicinal interventions, which often entail considerable side effects, this study seeks to explore traditional Ayurvedic methods that may offer sustainable relief.
Efficacy of Matra Vasti
Matra Vasti, a therapeutic procedure in Ayurveda, utilizes the Panchtikta Guggulu Ghrita, known for its anti-inflammatory and nourishing properties. In this trial, 40 patients diagnosed with Sandhivata were randomly divided into two groups. Group A received Laksha Guggulu, while Group B was treated with Laksha Guggulu combined with Matra Vasti of Panchtikta Guggulu Ghrita for 16 days. Results indicated that Group B exhibited significant improvements in pain reduction (91.43%), movement (96%), and swelling (96%) compared to Group A, reinforcing the notion that Matra Vasti is a more effective treatment for managing knee osteoarthritis-related symptoms.
Comparative Insights on Treatment Groups
Interestingly, the study highlights that while Group B demonstrated better overall recovery metrics, the statistical significance related to movement and swelling between the groups was not conclusive. In both groups, pain scores showed notable changes, yet the metrics on movement and swelling did not reveal significant differences at a statistical level. An evaluation of the distance walked in 15 minutes highlighted that Group B showed a higher percentage of improvement (22.27%) compared to Group A (16.03%). This suggests that although Matra Vasti is beneficial, both treatments may possess comparable effectiveness.
Conclusion
This study underscores the potential advantages of employing Matra Vasti of Panchtikta Guggulu Ghrita in managing Sandhivata (Osteoarthritis). It was concluded that patients tolerated this intervention well without encountering adverse effects. While favorable results were observed in pain relief, swelling reduction, and improved knee movement in the Matra Vasti cohort, further research is needed to definitively establish the comparative effectiveness of these Ayurvedic approaches against modern treatment methodologies. As OA increasingly burdens populations globally, integrating such inexpensive and accessible traditional treatments could offer essential complementary options for healthcare.
FAQ section (important questions/answers):
What is Sandhivata and how is it related to osteoarthritis?
Sandhivata is an Ayurvedic term for osteoarthritis, characterized by joint pain, swelling, and movement restriction due to vitiated Vata. It correlates with the progressive deterioration of joint cartilage that leads to discomfort and disability.
What are the key components of Matra Vasti of Panchtikta Guggulu Ghrita?
Matra Vasti consists of Panchtikta Guggulu Ghrita, an Ayurvedic preparation containing herbal components known for their anti-inflammatory and nourishing properties. It helps in pacifying Vata Dosha and providing relief in conditions like Sandhivata.
What were the results of the study on Matra Vasti?
The study found that Matra Vasti of Panchtikta Guggulu Ghrita provided significant relief in pain, movement, and swelling compared to Laksha Guggulu alone. However, statistically significant differences were noted primarily in pain relief.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Efficacy of matra vasti with panchtikta guggulu in osteoarthritis.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Guggulu:
Guggulu, used in both Matra Vasti and Laksha Guggulu, is a gum resin derived from the plant Commiphora mukul. It is known for its anti-inflammatory and antiarthritic properties, making it a crucial Ayurvedic drug in treating Sandhigata Vata (Osteoarthritis).
2) Vata:
Vata is a fundamental energy in Ayurvedic medicine, associated with movement and the nervous system. Imbalance in Vata Dosha is a key factor in Sandhigata Vata (Osteoarthritis), necessitating treatments that pacify Vata.
3) Ghrita (Ghrta):
Ghrita, or clarified butter, is frequently used in Ayurveda for its nourishing and rejuvenating properties. In this study, Panchtikta Guggulu Ghrita is used in Matra Vasti to treat Sandhigata Vata by simultaneously helping in the pacification of Vata Dosha.
4) Pain:
Pain is a primary symptom of Sandhigata Vata (Osteoarthritis). The study measures the severity of pain before and after treatment using a numerical pain rating scale to assess the efficacy of Matra Vasti of Panchtikta Guggulu Ghrita and Laksha Guggulu.
5) Swelling:
Swelling in the joints, specifically assessed in both right and left knee joints, is a clinical feature of Sandhigata Vata. The study evaluates the reduction in swelling as a key metric for the efficacy of treatments like Matra Vasti and Laksha Guggulu.
6) Matra:
Matra refers to 'measure' or 'dose.' In this study, Matra Vasti involves administering a specific measure (50 ml) of Panchtikta Guggulu Ghrita to patients with Sandhigata Vata (Osteoarthritis) to assess its therapeutic effects.
7) Laksha (Laksa):
Laksha is one of the components in Laksha Guggulu, an Ayurvedic formulation known for its effectiveness in bone-related disorders. In this study, Laksha Guggulu is used to treat Sandhigata Vata (Osteoarthritis).
8) Dhatu:
Dhatu refers to tissues in the body. In Sandhigata Vata, the degeneration of Dhatus, particularly Asthi Dhatu (bone tissue) and Majja Dhatu (bone marrow), is a critical factor that needs specific therapeutic interventions.
9) Sandhigata Vata (Sandhigata-vata):
[see source text or glossary: Sandhigata-vata]
10) Drug:
Drug in the context of this study refers to both Panchtikta Guggulu Ghrita used in Matra Vasti and Laksha Guggulu, both of which are Ayurvedic medicines evaluated for their efficacy in treating Sandhigata Vata (Osteoarthritis).
11) Disease:
Disease refers to the undesirable condition being treated, in this case, Sandhigata Vata (Osteoarthritis), characterized by joint pain, swelling, crepitus, and restricted movements due to cartilage degeneration.
12) Medicine:
Medicine in this study refers to Ayurvedic formulations like Matra Vasti of Panchtikta Guggulu Ghrita and Laksha Guggulu, which are assessed for their effectiveness in treating Sandhigata Vata (Osteoarthritis).
13) Vatadosha (Vatadosa, Vata-dosha):
Vatadosha refers to disturbances in Vata Dosha, which cause conditions like Sandhigata Vata. The study assesses treatments that pacify Vatadosha to alleviate symptoms of osteoarthritis.
14) Dosha (Dosa):
Dosha are the life principles in Ayurveda. Vata, Pitta, and Kapha are the three types. Sandhigata Vata involves an imbalance in Vata Dosha, requiring specific treatment to restore balance.
15) Tikta:
Tikta is one of the six tastes in Ayurveda, translating to 'bitter.' Many ingredients in Panchtikta Guggulu Ghrita have Tikta Rasa, which helps to clear blockages in bodily channels and pacify Vata Dosha.
16) Kshaya (Ksaya):
Kshaya refers to 'degeneration' or 'depletion,' particularly of Dhatus like Asthi (bone) and Majja (marrow) in Sandhigata Vata. Slowing down Dhatu Kshaya is one therapeutic aim.
17) Sharman (Sarma, Sharma, Sarman):
Sharma refers here to Dr. Neetu Sharma, one of the authors of the study evaluating the efficacy of Matra Vasti of Panchtikta Guggulu Ghrita in treating Sandhigata Vata (Osteoarthritis).
18) Asthi (Ashthi):
Asthi refers to 'bone' in Ayurvedic medicine. Sandhigata Vata involves the degeneration of Asthi Dhatu, requiring treatments that nourish and stabilize Asthi.
19) Dhatukshaya (Dhatuksaya, Dhatu-kshaya):
Dhatu-kshaya means 'tissue depletion,' particularly relevant in conditions like Sandhigata Vata (osteoarthritis) where bone (Asthi) and marrow (Majja) tissues are depleted.
20) Prakriti (Prakrti):
Prakriti refers to an individual's constitution based on the predominance of Doshas. In this study, a high prevalence of Vata-Pitta Prakriti was observed among patients with Sandhigata Vata.
21) Pitta:
Pitta is one of the three Doshas in Ayurveda, representing metabolic and transformative processes. The study notes that patients with Vata-Pitta Prakriti were more common among those suffering from Sandhigata Vata.
22) Guna:
Guna refers to qualities or attributes. In the context of this study, 'Snigdha Guna' (unctuous quality) and 'Ruksha Guna' (dry quality) are relevant as they affect Vata Dosha and tissue health.
23) Diet:
Diet plays a role in the exacerbation or pacification of Doshas. The study notes that vegetarian diets, which are generally less oily, may increase Ruksha Guna and vitiate Vata Dosha, potentially influencing Sandhigata Vata.
24) Pakvashaya (Pakvasaya, Pakva-ashaya):
Pakvashaya is the large intestine, considered a primary site of Vata Dosha in Ayurveda. Treatments like Matra Vasti target Pakvashaya to control Vata-related disorders like Sandhigata Vata.
25) Madhura:
Madhura, or 'sweet,' is one of the six Ayurvedic tastes. It is nourishing and pacifies Vata Dosha. Panchtikta Guggulu Ghrita has Madhura-Katu Vipaka, aiding in the nourishment of Dhatus.
26) Snigdha:
Snigdha means 'unctuous' or 'oily,' a quality that opposes the dryness characteristic of Vata Dosha. Medicines like Panchtikta Guggulu Ghrita have Snigdha Guna to pacify Vata in Sandhigata Vata.
27) Vipaka:
Vipaka refers to the post-digestive effect of a substance. Medicines like Panchtikta Guggulu Ghrita, having Madhura-Katu Vipaka, help in the nourishment and stabilization of Dhatus, aiding in Sandhigata Vata treatment.
28) Kapha:
Kapha is one of the three Doshas, associated with structure and lubrication in the body. The study notes that nourishment of Sleshaka Kapha at the joint level is important for treating Sandhigata Vata.
29) Virya:
Virya refers to the potency or efficacy of a substance. Panchtikta Guggulu Ghrita in the study has Ushna Virya, which helps promote metabolic functions and pacify Vata Dosha.
30) Blood:
Blood circulation is crucial for delivering nutrients to body tissues. Ayurvedic treatments like Snehana and Swedana enhance blood flow, thereby aiding in the healing process of Sandhigata Vata.
31) Rasa (Rasha):
Rasa refers to taste or essence. In Ayurvedic medicine, tastes like Tikta (bitter) are used to pacify Vata Dosha. The Panchtikta Guggulu Ghrita used in the study contains herbs with Tikta Rasa.
32) New Delhi:
New Delhi is where the Ch. Brahm Prakash Ayurved Charak Sansthan, one of the study sites, is located. The patients for the study on Sandhigata Vata were selected from this location.
33) Asthidhatu (Asthi-dhatu):
Asthi-dhatu refers to bone tissue in Ayurveda. In Sandhigata Vata, degeneration of Asthi-dhatu occurs, necessitating treatments like Panchtikta Guggulu Ghrita to nourish and stabilize this tissue.
34) Majjadhatu (Majja-dhatu):
Majja-dhatu is bone marrow in Ayurveda. In Sandhigata Vata (osteoarthritis), degeneration of Majja-dhatu is a concern. The study aims to stabilize this tissue with treatments like Panchtikta Guggulu Ghrita.
35) Vatapitta (Vata-pitta):
Vata-pitta Prakriti refers to a body constitution dominated by Vata and Pitta Doshas. The study found a high prevalence of Vata-pitta Prakriti among patients with Sandhigata Vata.
36) Stiffness:
Stiffness is a symptom of Sandhigata Vata (osteoarthritis). The study assesses the efficacy of Ayurvedic treatments like Matra Vasti and Laksha Guggulu in reducing stiffness in affected joints.
37) Snehana:
Snehana refers to oiling or oleation therapy in Ayurveda, essential for treating Vata disorders like Sandhigata Vata. It helps in nourishing dry tissues and increasing flexibility by reducing stiffness.
38) Sandhi (Shandhi, Samdhi):
Sandhi refers to joints in Ayurvedic terminology. Sandhigata Vata involves the degeneration of joints, causing pain and other symptoms that are the focus of treatment in this study.
39) Ushna (Usna):
Ushna means 'hot' or 'warm' in Ayurveda. Ingredients with Ushna Virya in Panchtikta Guggulu Ghrita promote metabolic functions and help in stabilizing Vata Dosha, aiding in the treatment of Sandhigata Vata.
40) Majja:
Majja is bone marrow in Ayurveda, vital for joint health. In the study, the degeneration of Majja is addressed through therapies like Matra Vasti with Panchtikta Guggulu Ghrita to nourish and stabilize this tissue.
41) Delhi:
Delhi refers to the location of Ch. Brahm Prakash Ayurved Charak Sansthan, where the study on the efficacy of Matra Vasti of Panchtikta Guggulu Ghrita in treating Sandhigata Vata was conducted.
42) Balya:
Balya refers to treatments or substances that provide strength. Ingredients in Panchtikta Guggulu Ghrita and Laksha Guggulu are Balya, aiding in the strengthening of joints affected by Sandhigata Vata.
43) Vaya:
Vaya refers to age in Ayurveda. The study includes patients from the age group 40-70, as Sandhigata Vata is more prevalent in older individuals who undergo age-related Dhatu Kshaya.
44) Katu:
Katu is one of the six tastes in Ayurveda, translating to 'pungent.' Katu Vipaka in Panchtikta Guggulu Ghrita helps in metabolic processes and the nourishment of Dhatus, aiding in Sandhigata Vata treatment.
45) Ashvagandha (Asvagandha, Ashwagandha, Ashvagamdha, Ashva-gandha):
Ashwagandha is an Ayurvedic herb known for its rejuvenating properties. It is one of the ingredients in Laksha Guggulu used to treat Sandhigata Vata (osteoarthritis) in this study.
46) Bhaishajya (Bhaisajya):
Bhaishajya refers to medicinal formulations in Ayurveda. Bhaishajya Ratnavali is a classical Ayurvedic text that mentions formulations like Laksha Guggulu, used in the study to treat Sandhigata Vata.
47) Vatavyadhi (Vata-vyadhi):
Vatavyadhi refers to diseases caused by Vata Dosha imbalances. In Ayurvedic texts, Panchtikta Guggulu Ghrita is mentioned for treating Vatavyadhi, which includes Sandhigata Vata (osteoarthritis).
48) Shothaghna (Sothaghna, Shotha-ghna):
Shothaghna refers to substances that reduce swelling. Ingredients in Panchtikta Guggulu Ghrita and Laksha Guggulu possess Shothaghna properties that help manage the swelling associated with Sandhigata Vata.
49) Prasarana:
Prasarana means 'extension' of limbs. Pain during Prasarana is a symptom of Sandhigata Vata (osteoarthritis), and the study measures improvement in this symptom as part of the treatment efficacy assessment.
50) Madhyama:
Madhyama refers to the middle-aged stage of life. In this study, a majority of patients (67.50%) fall into the Madhyama Vaya range, indicating that Sandhigata Vata commonly affects this age group.
51) Sparsha (Sparsa):
Sparsha refers to touch or palpation. In Sandhigata Vata, signs like Vatapoornadrithivat Sparsha, where the joint feels like an air-filled bag on palpation, are diagnostic criteria assessed in the study.
52) Bhagna:
Bhagna refers to bone fractures. Laksha Guggulu, used in the study, is traditionally effective for Bhagna management due to its bone-healing properties, making it relevant for treating Sandhigata Vata.
53) Shotha (Sotha):
Shotha means 'swelling' in Ayurvedic terms. It is a symptom of Sandhigata Vata (osteoarthritis), and the reduction of Shotha is a key measure of treatment efficacy in the study.
54) Tvacha:
Tvacha means 'skin' in Ayurveda. Abhayanga (massage) on Tvacha and underlying tissues like Snayu (ligaments) and Rakta (blood vessels) helps relieve symptoms like stiffness in Sandhigata Vata.
55) Ruksha (Ruksa):
Ruksha means 'dryness,' a quality that aggravates Vata Dosha. The study finds that a predominantly vegetarian diet, which is less oily and thus increases Ruksha Guna, may influence the prevalence of Sandhigata Vata.
56) Srotas (Shrotas):
Srotas are bodily channels through which nutrients and waste products move. Cleansing Srotas is essential in treating conditions like Sandhigata Vata, as obstructed channels can worsen the symptoms.
57) Jaipur:
Jaipur is home to SSSB Ayurvedic College & Hospital, where Dr. Neetu Sharma, one of the authors, is an Assistant Professor. This institution participated in the study on Sandhigata Vata.
58) Sneha:
Sneha refers to 'fat' or 'oil,' used in the form of Ghrita (clarified butter) in Sneha Vasti to treat Sandhigata Vata. Sneha therapy helps nourish dry tissues and pacify Vata Dosha.
59) Snayu:
Snayu refers to ligaments in Ayurvedic terms. Abhayanga (massage) on Snayu and related tissues helps relieve stiffness and pain, enhancing the efficacy of treatments for Sandhigata Vata.
60) Edema (Oedema):
Edema refers to swelling caused by fluid retention. In the study, joint swelling, a form of edema, is assessed before and after treatments like Matra Vasti and Laksha Guggulu to measure efficacy.
61) Roga:
Roga means 'disease' in Ayurveda. In this study, Sandhigata Vata (osteoarthritis) is the Roga being treated with Ayurvedic remedies like Matra Vasti of Panchtikta Guggulu Ghrita and Laksha Guggulu.
62) Commiphora mukul:
Commiphora mukul, known as Guggulu, is a plant resin used for its anti-inflammatory and antiarthritic properties. It is a key ingredient in Panchtikta Guggulu Ghrita for treating Sandhigata Vata.
63) Madhyamvaya (Madhyam-vaya):
Madhyam-vaya refers to middle age in Ayurvedic terms. The study notes that a significant proportion of Sandhigata Vata (osteoarthritis) patients fall within this age group.
64) Tiktadravya (Tikta-dravya):
[see source text or glossary: Tikta-dravya]
65) Tuberculosis:
Tuberculosis (TB) is among the exclusion criteria for the study. Patients with TB are not included in the research on the efficacy of Matra Vasti of Panchtikta Guggulu Ghrita in treating Sandhigata Vata.
66) Discussion:
Discussion in the study includes interpretation of results, demographic data, and the efficacy of treatments like Matra Vasti and Laksha Guggulu in managing Sandhigata Vata, aiming for comprehensive insights.
67) Dhatvagni (Dhatu-agni):
Dhatvagni refers to the metabolic functions at the tissue level. Ingredients in Panchtikta Guggulu Ghrita, with their Katu Vipaka and Ushna Virya, promote Dhatvagni, aiding in the treatment of Sandhigata Vata.
68) Mahabhuta (Maha-bhuta):
Mahabhuta refers to the five great elements in Ayurveda. Tikta Rasa, predominant in Panchtikta Guggulu Ghrita, is associated with Akasha Mahabhuta, aiding in removing obstructions in bodily channels.
69) Prakarana:
Prakarana refers to a chapter or section in Ayurvedic texts. Acharya Vagbhatta mentioned Panchtikta Guggulu Ghrita in the Vatavyadhi chikitsa prakarana, highlighting its efficacy in Sandhigata Vata.
70) Vataroga (Vata-roga):
Vata-roga are disorders caused by an imbalance in Vata Dosha. Sandhigata Vata is a Vata-roga treated in this study with therapies like Matra Vasti of Panchtikta Guggulu Ghrita and Laksha Guggulu.
71) Ayurveda (Ayus-veda):
Ayurveda is the ancient Indian system of medicine. The study uses Ayurvedic treatments like Matra Vasti of Panchtikta Guggulu Ghrita to manage Sandhigata Vata, leveraging Ayurvedic principles.
72) Tridosha (Tridosa, Tri-dosha):
Tridosha refers to the three primary energies (Vata, Pitta, Kapha) in Ayurveda. Effective treatment for Sandhigata Vata considers balancing these Doshas, particularly pacifying aggravated Vata.
[Note: The above list is limited to 75. Total glossary definitions available: 97]
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