"Tabernamontana divaricata alleviates oxidative stress in diabetic rats."
Journal name: Ancient Science of Life
Original article title: Amelioration of oxidative stress by Tabernamontana divaricata on alloxan-induced diabetic rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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S. K. Kanthlal, B. Anil Kumar, Jipnomon Joseph, R. Aravind, P. Royal Frank
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Amelioration of oxidative stress by Tabernamontana divaricata on alloxan-induced diabetic rats
Year: 2014
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, affecting over 200 million individuals worldwide. This condition can lead to severe complications, including damage to the kidneys, nerves, and eyes, primarily due to increased oxidative stress associated with uncontrolled blood sugar levels. Traditional synthetic hypoglycemic agents often come with adverse side effects, leading to a growing interest in natural alternatives. The study investigates the anti-diabetic potential and antioxidant effects of the ethanol extract of Tabernamontana divaricata (L.), commonly known as Crepe Jasmine, on alloxan-induced diabetic rats.
Antioxidant and Anti-diabetic Activity of Tabernamontana divaricata
The research demonstrated that the methanol extract of T. divaricata possesses significant anti-diabetic properties, evident through its ability to lower blood glucose levels and improve altered biochemical parameters in diabetic rats. The extract was administered in two doses (100 mg/kg and 200 mg/kg), with the higher dose exhibiting more pronounced effects. Additionally, the study highlighted the extract's capacity to restore the levels of various antioxidant enzymes, including superoxide dismutase and catalase, which were compromised in the diabetic state. These findings suggest that T. divaricata may mitigate oxidative stress and restore metabolic balance, potentially due to its rich flavonoid and antioxidant constituents.
Conclusion
In conclusion, the findings suggest that Tabernamontana divaricata exhibits substantial anti-diabetic and antioxidant effects in alloxan-induced diabetic rats, comparable to the standard drug glibenclamide. This plant may contain beneficial biomolecules that enhance insulin sensitivity or stimulate insulin secretion in the pancreas. Given the potential for natural remedies in managing diabetes and its complications, further research is warranted to isolate and characterize the active phytoconstituents responsible for these therapeutic effects and to explore their mechanisms of action.
FAQ section (important questions/answers):
What is the main objective of the study on Tabernamontana divaricata?
The study aimed to evaluate the anti-diabetic activity of the ethanol extract of Tabernamontana divaricata and its effects on oxidative stress in alloxan-induced diabetic rats.
What was the methodology used for inducing diabetes in rats?
Diabetes was induced in rats by a single intraperitoneal injection of alloxan monohydrate (140 mg/kg body weight). Rats were then treated with various doses of methanol extract and glibenclamide to assess anti-diabetic effects.
What were the significant findings regarding blood glucose levels?
The administration of the methanol extract significantly reduced blood glucose levels in diabetic rats, particularly at the 200 mg/kg dosage, indicating strong anti-diabetic potential.
What conclusions were drawn about Tabernamontana divaricata's effects?
Tabernamontana divaricata demonstrated significant anti-diabetic activity and beneficial effects on oxidative stress, suggesting it may contain compounds that support insulin regulation and protect against oxidative damage.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for �"Tabernamontana divaricata alleviates oxidative stress in diabetic rats."�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood refers to the fluid that circulates through the body's cardiovascular system, transporting oxygen, nutrients, hormones, and waste products. In the context of diabetes, blood glucose levels are critical indicators of metabolic health, and monitoring these levels helps assess the effectiveness of treatments like those investigated with Tabernamontana divaricata.
2) Amrita (Amrta):
Amrita, or Amrita Viswa Vidyapeetham University, is an educational institution in India known for its emphasis on health sciences, including pharmacy. The study of the anti-diabetic properties of Tabernamontana divaricata was conducted at the Amrita School of Pharmacy, highlighting the institution's role in pharmaceutical research.
3) Pharmacology:
Pharmacology is the branch of medicine that deals with the study of drugs and their effects on living organisms. It is crucial in understanding how Tabernamontana divaricata's extracts influence blood sugar levels and oxidative stress in diabetic models, contributing to the development of safer anti-diabetic therapies.
4) Activity:
Activity refers to the functional effect of biological substances, including drugs or plant extracts, on physiological processes. The anti-diabetic activity of the ethanol extract from Tabernamontana divaricata shows its potential to reduce blood glucose levels, providing new avenues for diabetes management strategies.
5) Phytochemical:
Phytochemicals are biologically active compounds found in plants that may have health benefits. In this study, the phytochemical evaluation of Tabernamontana divaricata helps identify constituents responsible for its medicinal properties, leading to a better understanding of how these compounds can combat diabetes and its complications.
6) Flavonoid:
Flavonoids are a group of phytochemicals known for their antioxidant properties. They play a significant role in combating oxidative stress, which is a critical factor in diabetes. The presence of flavonoids in Tabernamontana divaricata may enhance its therapeutic efficacy and support further research into its anti-diabetic effects.
7) Sugar:
Sugar, primarily glucose, is a vital source of energy for the body. In diabetes research, controlling blood sugar levels is paramount. The study examines how Tabernamontana divaricata affects blood sugar in diabetic rats, contributing to understanding natural interventions for managing diabetes and preventing complications.
8) Drug:
A drug is any substance used to treat, prevent, or diagnose a disease. The investigation into Tabernamontana divaricata aims to establish if its extracts can serve as a natural drug alternative or complement to synthetic anti-diabetics, exploring safe and effective treatments for diabetes management.
9) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world. The research on Tabernamontana divaricata exemplifies the application of scientific principles to understand its pharmacological effects, contributing to the body of knowledge regarding traditional medicine and modern pharmacotherapy.
10) Pharmacological:
Pharmacological refers to the study of how drugs interact with biological systems. This term is relevant in the context of examining how the extracts of Tabernamontana divaricata can modify physiological responses, particularly in reducing blood glucose levels and mitigating oxidative stress in diabetic rats.
11) Inflammation:
Inflammation is the body's response to injury or infection, often contributing to chronic conditions like diabetes. The study's relevance lies in investigating whether Tabernamontana divaricata can modulate inflammatory responses, potentially improving diabetic conditions and offering new strategies for inflammation-related complications.
12) Discussion:
Discussion in scientific articles is a section where authors interpret their findings and relate them to existing research. This part of the study on Tabernamontana divaricata facilitates understanding of the significance of results, implications for future research and how this plant may impact diabetes treatment paradigms.
13) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing diseases. The exploration of the anti-diabetic properties of Tabernamontana divaricata adds to alternative medicine approaches, encouraging research into how traditional remedies can inform modern therapeutic practices in diabetes care.
14) Jasmine:
Jasmine typically refers to a genus of flowering plants, and in this context, it relates specifically to Tabernamontana divaricata, also known as Crepe Jasmine. This plant, with its aromatic flowers, is investigated for pharmacological potential, highlighting the intersection between botanical aesthetics and medicinal applications.
15) Bitter:
Bitter taste is often associated with certain bioactive compounds in plants. In traditional medicine, bitterness can indicate potential therapeutic benefits. The study assesses the bitterness of Tabernamontana divaricata, which may signal the presence of compounds contributing to its anti-diabetic and antioxidant properties.
16) Botany:
Botany is the scientific study of plants, including their structure, properties, and biochemical processes. The research on Tabernamontana divaricata underscores the importance of botany in identifying and validating plants with medicinal properties, fostering a link between plant science and potential therapeutic applications.
17) Water:
Water is essential for all forms of life and plays a critical role in physiological processes. In the context of pharmacological studies, the extraction and preparation of plant materials like Tabernamontana divaricata require water, which affect the bioavailability and efficacy of its active compounds used for therapeutic purposes.
18) Acrid:
Acrid describes a sharp, bitter taste or smell, often associated with certain medicinal plants. In the study of Tabernamontana divaricata, the acrid characteristics of its root might be linked to its pharmacological effects, contributing insights into how taste profiles can reflect botanical uses in traditional medicine.
Other Science Concepts:
Discover the significance of concepts within the article: �"Tabernamontana divaricata alleviates oxidative stress in diabetic rats."�. Further sources in the context of Science might help you critically compare this page with similair documents:
Diabetes mellitus, Oxidative stress, Serum lipid profile, Lipid peroxidation, Oxidative damage, Phytochemical evaluation, Glycosylated hemoglobin, Ethanol extract, Anti-diabetic activity, Methanol extract, Protective effect, Blood glucose level, Metabolic disease, Antioxidant enzyme, Hypoglycemic agent, Alloxan induced diabetic rat, Wistar albino rat.