Evaluation of Hedychium spicatum rhizome extracts for pharmacology
Journal name: Ancient Science of Life
Original article title: Pharmacological evaluation of extracts of Hedychium spicatum (Ham-ex-Smith) rhizome
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Shivani Ghildiyal, Manish K. Gautam, Vinod K. Joshi, Raj K. Goel
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Pharmacological evaluation of extracts of Hedychium spicatum (Ham-ex-Smith) rhizome
Year: 2012
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Hedychium spicatum, commonly known as Shati, is a perennial rhizomatous herb belonging to the Zingiberaceae family, primarily found in the subtropical Himalayan regions of India. Traditionally utilized in Ayurveda, its rhizome is documented for treating various ailments, including cough, respiratory issues, and fever. The current study investigates the pharmacological effects of aqueous and ethanolic extracts of the dried rhizome of H. spicatum, focusing on its anti-histaminic, anti-inflammatory, and analgesic properties, as well as its safety profile.
Anti-Histaminic and Protective Effects
The study highlights the significant anti-histaminic action of both H. spicatum extracts demonstrated through a dose-dependent response against histamine-induced bronchospasm in guinea pigs. The extracts were effective in extending the pre-convulsive dyspnoea time, indicating protective effects against respiratory constriction. Additionally, both extracts exhibited a protective effect against histamine-induced gastric ulcers, suggesting their potential in safeguarding gastric health. These findings are essential as they validate the indigenous use of H. spicatum in managing respiratory disorders and highlight its role as a natural alternative to synthetic antihistamines.
Conclusion
This research substantiates the traditional therapeutic applications of Hedychium spicatum, showcasing its bronchodilator, anti-inflammatory, and analgesic properties. The observed pharmacological effects affirm the plant's utilization in alleviating symptoms associated with respiratory conditions like asthma. Furthermore, the lack of toxicity even at higher doses reinforces the safety profile of H. spicatum, indicating its potential as a reliable herbal remedy for respiratory inflammation and associated discomfort.
FAQ section (important questions/answers):
What is Hedychium spicatum used for in traditional medicine?
Hedychium spicatum, known as Shati, is traditionally used for treating cough, fever, hiccough, and respiratory problems. It has also been used in Ayurveda for its anti-inflammatory and analgesic properties.
What effects were studied in the research on Hedychium spicatum?
The study evaluated the anti-histaminic, anti-inflammatory, analgesic, and ulcer-protective effects of aqueous and ethanolic extracts of Hedychium spicatum rhizome using animal models.
What were the findings regarding the safety of Hedychium spicatum extracts?
The extracts showed no toxic effects, even at doses ten times higher than the effective dose, indicating the safety of Hedychium spicatum for medicinal use.
How were the extracts of Hedychium spicatum administered in the study?
The extracts were administered orally to guinea pigs and rats as a suspension in 1% carboxymethyl cellulose, once daily for specific durations based on the experiment.
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Hedychium spicatum, Pharmacological evaluation, Analgesic effect, Acute toxicity, Anti-inflammatory effect, Department of Dravyaguna, Carrageenan-induced paw edema, Ethical Permission, Anti-histaminic activity, Histamine-induced bronchospasm, Essential oil components, Respiratory disorder, Aqueous and ethanolic extract, Indigenous use.