Significance of Acute toxicity
Acute toxicity refers to the harmful effects of a substance that result from a single exposure or from multiple exposures over a short time frame. This concept is significant in evaluating the safety of various substances, particularly pharmaceuticals, in both living organisms and aquatic environments. Assessment methods for acute toxicity often involve measuring indicators such as LD50 and EC50, focusing on the immediate adverse effects observed shortly after high dose exposure to toxic substances, as detailed in numerous studies involving various extracts on animal models.
Synonyms: Short-term toxicity, High toxicity, Severe toxicity, Poisoning, Lethal concentration
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The concept of Acute toxicity in scientific sources
Acute toxicity involves harmful effects from brief exposure to a substance, such as high doses of vitamin A, which can cause immediate adverse symptoms and pose serious health risks.
From: The Malaysian Journal of Medical Sciences
(1) A measure of the adverse effects of a substance after a single dose, which was tested for the extract at a high concentration, as noted in the provided text.[1] (2) This is the adverse effects that result from a single dose or a short-term exposure, which were determined for pulegone through oral and dermal routes in rats.[2] (3) The harmful effects caused by exposure to a substance within a short period of time.[3] (4) The assessment of the harmful effects of a single or short-term exposure to a substance, in this case, the extract from Pandanus foetidus.[4] (5) Acute toxicity refers to the harmful effects of a substance that result from a single exposure or multiple exposures in a short period, often measured by the median lethal dose (LD50).[5]