Coccinia grandis extract improves liver enzymes and lipid profile in diabetic rats.
Journal name: Ancient Science of Life
Original article title: Ameliorative potential of Coccinia grandis extract on serum and liver marker enzymes and lipid profile in streptozotocin induced diabetic rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Dr. S. Krishnakumari, P. Bhuvaneswari, P. Rajeswari
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Ameliorative potential of Coccinia grandis extract on serum and liver marker enzymes and lipid profile in streptozotocin induced diabetic rats
Year: 2011
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Diabetes mellitus has emerged as one of the most pressing health issues of the 21st century, significantly affecting metabolic activities throughout the body. The disease, characterized by high levels of circulating glucose, can lead to severe complications if not managed properly. In response to the growing prevalence of diabetes, there has been an increasing interest in exploring herbal remedies as a safer treatment alternative. One such remedy is the extract of Coccinia grandis, a plant widely used in traditional medicine for its potential medicinal properties, including the treatment of diabetes and its associated complications.
Ameliorative Effects of Coccinia grandis Extract
The study highlighted in the article investigates the effects of Coccinia grandis extract on serum and liver marker enzymes and lipid profiles in streptozotocin-induced diabetic rats. The research found that diabetes resulted in elevated levels of crucial liver enzymes (ALP, AST, ALT, and LDH) and abnormal lipid profiles, indicating liver damage and metabolic dysregulation. Treatment with the methanolic extract of Coccinia grandis significantly restored these enzyme levels and lipid profiles towards normalcy, suggesting the extract's hepatoprotective and hypolipidemic properties. The observed effects may be attributed to the flavonoids present in the plant, which are known to exert beneficial actions on liver function and metabolic health.
Conclusion
The findings of this study provide compelling evidence for the use of Coccinia grandis as a natural therapeutic agent to manage diabetes and its complications effectively. By restoring normal enzyme and lipid levels in diabetic rats, the extract demonstrates not only its protective effects on liver function but also its potential as an alternative treatment to conventional drugs. Given the rising incidence of diabetes and the limitations of current pharmacotherapies, further research into Coccinia grandis may pave the way for developing safer and more effective herbal treatments for diabetes management.
FAQ section (important questions/answers):
What is the focus of the study involving Coccinia grandis?
The study evaluates the potential of Coccinia grandis extract to restore serum and liver marker enzymes, as well as lipid profiles in streptozotocin-induced diabetic rats.
How does diabetes affect liver marker enzymes and lipid profiles?
Diabetes causes increased levels of liver marker enzymes and lipid profile changes due to disrupted glucose and lipid metabolism, leading to hepatotoxic effects and hyperlipidemia.
What methods were used to conduct the experiment on rats?
The experiment involved dividing rats into control and diabetic groups, administering Coccinia grandis extract, and measuring levels of serum and liver enzymes and lipids after a treatment period.
What were the findings after administering Coccinia grandis extract?
The administration of Coccinia grandis extract significantly reduced elevated serum and liver enzyme levels and lipid profiles in diabetic rats, indicating its potential for restoring metabolic balance.
Other Science Concepts:
Discover the significance of concepts within the article: �Coccinia grandis extract improves liver enzymes and lipid profile in diabetic rats.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Flavonoid, Diabetes mellitus, Hyperlipidemia, Total cholesterol, Lipid profile, Hyperglycemia, Methanolic extract, Streptozotocin-induced diabetic rats, Epidemiological data, Hepatotoxic Effect, Normal level, Experimental animal, Experimental regimen, Serum enzymes, Marker enzyme, Standard laboratory condition, Urban-rural difference, Administration of plant extract, Plasma lipoprotein.
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