Purgative and anti-inflammatory activities of cassia didymobotrya, fresen
Journal name: Ancient Science of Life
Original article title: Purgative and anti-inflammatory activities of cassia didymobotrya, fresen
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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N. Mahadevan, B.G. Upendra, T. Subburaju, K. Elango, B. Suresh
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Purgative and anti-inflammatory activities of cassia didymobotrya, fresen
Year: 2002
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Cassia didymobotrya, a plant from the Fabaceae family, is prevalent in the Nilgiris district of Tamil Nadu, India. The leaves of this plant are traditionally utilized in several African countries for various ailments, including malaria and gastrointestinal issues, and are known for their purgative properties. This study examines the purgative and anti-inflammatory activities of aqueous and ethanol extracts of Cassia didymobotrya, assessing their effectiveness compared to established medications, Senna and Indomethacin, in animal models.
Purgative and Anti-Inflammatory Activities
The investigation utilized both the ethanol and aqueous extracts to evaluate purgative effects in mice and anti-inflammatory effects in albino rats. The results indicated that both extracts exhibited significant purgative activity, with the ethanol extract proving more effective than the aqueous extract. In terms of anti-inflammatory activity, both extracts demonstrated significant reductions in paw edema induced by carrageenan, with the ethanol extract showing earlier and more substantial effects compared to the aqueous extract. The percentage protection of edema at four hours was recorded at 35.29% for the aqueous extract, 37.25% for the ethanol extract, and 43.13% for indomethacin, emphasizing the potential of Cassia didymobotrya as an alternative therapeutic option.
Conclusion
The findings from this study suggest that Cassia didymobotrya possesses notable purgative and anti-inflammatory properties, making it a valuable candidate for further research in phytotherapy. Both the aqueous and ethanol extracts showed promising results, particularly the ethanol extract, which outperformed the aqueous extract in both tests. The study's outcomes support the traditional use of this plant and highlight the need for more extensive investigation to fully understand its therapeutic potential and mechanisms of action.
FAQ section (important questions/answers):
What were the main findings regarding the purgative effects?
Both aqueous and ethanol extracts of Cassia didymobotrya showed significant purgative effects in mice, with ethanol extract exhibiting higher activity compared to aqueous extract and comparable to the standard drug Senna.
How was the anti-inflammatory activity of the extracts tested?
The anti-inflammatory effects were measured using the 1% carrageenan-induced paw edema method in rats, with significant reduction in edema observed for both extracts, especially the ethanol extract, compared to the control.
What dosage of Cassia didymobotrya extracts was administered in the study?
The study administered both aqueous and ethanol extracts at a dosage of 100 mg/kg body weight for assessing purgative and anti-inflammatory activities in mice and rats.
What specific compounds are found in Cassia didymobotrya?
The plant contains several compounds, including 伪-amyrin, 尾-amyrin, chrysophanic acid, and various fatty acids and glycosides, contributing to its medicinal properties for various ailments.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淧urgative and anti-inflammatory activities of cassia didymobotrya, fresen鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
The term 'Activity' in this context refers to the biological effects exhibited by the extracts of Cassia didymobotrya. Specifically, it describes the purgative and anti-inflammatory activities observed in the study, indicating how these plant extracts can influence physiological processes in tested animals, such as inducing bowel movements or reducing inflammation.
2) Edema (Oedema):
Edema refers to the swelling caused by the accumulation of fluid in tissues, which is a physiological response often used in studies to assess inflammation. In this study, 1% carageenan-induced paw edema is utilized to evaluate the anti-inflammatory effect of Cassia didymobotrya extracts by measuring the reduction in swelling post-treatment.
3) Drug:
In this research, 'Drug' encompasses both the ethanol and aqueous extracts of Cassia didymobotrya, as well as the standard comparison drugs, Senna and Indomethacin. These substances are analyzed for their pharmacological effects, specifically their abilities to induce purgative actions and alleviate inflammation, further contributing to the understanding of their therapeutic potential.
4) Water:
Water is significant here as it serves as a solvent for extracting the bioactive compounds from Cassia didymobotrya. The aqueous extract is compared against the ethanol extract in terms of purgative and anti-inflammatory activities, highlighting the role of different solvents in influencing the extraction efficacy and resultant therapeutic effects.
5) Pharmacology:
Pharmacology is the branch of medicine that deals with the study of drugs and their effects on biological systems. The study falls within this scope as it evaluates the medicinal properties of Cassia didymobotrya extracts, providing insights into their mechanism of action, efficacy, and potential applications in treating various ailments.
6) Science (Scientific):
The term 'Science' in this document encompasses the systematic investigation and methodical approach applied in researching the medicinal properties of Cassia didymobotrya. The study is rooted in scientific methodology, including rigorous testing protocols and statistical analyses, to draw reliable conclusions regarding the extracts鈥� pharmacological activities.
7) Usa (U峁Ｄ�, Us膩, 弄sa, Usha, U峁, 弄峁Ｄ�, 弄峁):
The name 'Usha' appears as part of the reference for methodology and results in the study, indicating a contributor to the field of pharmacological research. In this context, it represents the collaborative nature of scientific inquiry, where contributions from various researchers enrich the body of knowledge surrounding drug efficacy and safety.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Purgative and anti-inflammatory activities of cassia didymobotrya, fresen鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Senna, Treatment group, Anti-inflammatory activity, Aqueous extract, Indomethacin, Ethanol extract, Mice, Shade-dried, Purgative activity, Paw edema, Carageenan induced paw edema, Botanical Survey of India, Reduced pressure, Desiccator, Percentage protection, Wistar albino rat.