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Clinical trial of phalaghrita on female infertility

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Journal name: Ancient Science of Life
Original article title: Clinical trial of phalaghrita on female infertility
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

Dr. S.P. Otta, Dr. R.N. Tripaty


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Clinical trial of phalaghrita on female infertility

Year: 2002

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study aimed to evaluate the efficacy of phalaghrita, an Ayurvedic herbal preparation, in treating female infertility through a controlled clinical trial involving 30 women. Female infertility, or stree bandhyatwa, can stem from various causes, including defects in ovulation, hormonal functions, and structural issues with the reproductive organs. After thorough clinical assessments, participants were treated with phalaghrita during three consecutive menstrual cycles, with a focus on identifying the causes of infertility and measuring the drug's effectiveness.

Effectiveness of Phalaghrita in Treating Infertility

The trial revealed that phalaghrita exhibited a notable overall effectiveness of 46.67% across various causes of female infertility. Participants were assessed on multiple criteria, including the occurrence of amenorrhea, ovulation, and the patency of fallopian tubes, with evaluations conducted after each treatment cycle. Among women with fertility issues, significant clinical improvement was observed, including a reported 60% of participants experiencing regular ovulatory cycles and a 50% reduction in tubal blockage. The findings suggest that phalaghrita may alleviate symptoms associated with infertility and has the potential to enhance reproductive health.

Conclusion

In conclusion, the study indicates that the intrauterine administration of phalaghrita is an effective treatment modality for female infertility, providing promising results in the relief of associated symptoms and improvement in reproductive functions. However, it is recommended to conduct further research involving a larger sample size to corroborate the efficacy and safety of phalaghrita in treating infertility. The findings highlight the relevance of traditional Ayurvedic practices in modern medicine, specifically in addressing complex health conditions like infertility.

FAQ section (important questions/answers):

What was the purpose of the study on phalaghrita?

The study aimed to evaluate the effectiveness of phalaghrita in treating female infertility cases through intrauterine insufflation over three consecutive menstrual cycles.

How many patients participated in the clinical trial?

A total of 30 female patients with infertility were included in the clinical trial, focusing on various causes and conditions affecting fertility.

What criteria were used for patient selection in the study?

Selection criteria included married females aged 20-30 years, with specific subjective and objective symptoms of infertility, while excluding those with certain medical conditions.

What were the results of the phalaghrita treatment after three cycles?

After three cycles of treatment, 60% of patients observed favorable results, with significant improvements in infertility, ovulation, and related symptoms, indicating the drug's effectiveness.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Clinical trial of phalaghrita on female infertility�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
In the context of the clinical trial, 'drug' refers to phalaghrita, a herbal preparation administered to treat female infertility. It operates through local application methods, offering insights into alternative treatment modalities that align with traditional Ayurvedic practices while addressing modern gynecological issues, thereby showcasing the relevance of herbal medicine.

2) Haridra (HÄridra, HaridrÄ):
Haridra, or turmeric, is a key herbal component in phalaghrita known for its anti-inflammatory and antioxidant properties. In Ayurvedic medicine, it is used to promote overall health and has therapeutic implications in addressing conditions like infertility by nourishing the reproductive system and enhancing the quality of uterine lining.

3) Burning sensation:
This symptom could indicate issues such as infections, inflammation, or hormonal imbalances affecting women's reproductive health. In the study, the assessment of associated symptoms like burning sensation was crucial for evaluating treatment effectiveness, as relief from such discomforts was considered an important measure of the drug's therapeutic success.

4) Science (Scientific):
The integration of ancient Ayurvedic practices with modern scientific methods highlights the relevance of science in understanding and validating traditional treatments like phalaghrita. This harmonization ensures that herbal medicines receive the scrutiny necessary for acceptance within contemporary medical frameworks, facilitating broader applicability and credibility.

5) Triphala (TriphalÄ, Tri-phala):
Triphala is a composition of three fruits—amla, haritaki, and bibhitaki—known for their synergistic health benefits. Within phalaghrita, it serves to enhance digestive health and detoxification, thereby improving overall reproductive function. Its presence in the formulation highlights the importance of holistic approaches in addressing infertility

6) Ghrita (Ghá¹›ta):
Ghrita refers to clarified butter and is a base in many Ayurvedic formulations, including phalaghrita. Its properties facilitate the absorption of herbal ingredients and provide nourishment to tissues. The use of ghrita symbolizes the traditional Ayurvedic emphasis on using fats for their therapeutic benefits, particularly in reproductive health.

7) Water:
Water is a critical component in preparing herbal formulations, as it is used to 'cook' or enhance the herbal potency of ghrita in the context of ghrita-paka. The balance between water and ghee is essential for ensuring the right therapeutic effects while preserving the integrity of the active ingredients.

8) Ghi (Ghī, Ghee):
Ghee, or clarified butter, is fundamental to Ayurvedic medicine for its nourishing qualities. In phalaghrita, it serves as the main carrier for potent herbs, facilitating their therapeutic effects. The integration of ghee into this treatment exemplifies the ancient knowledge of food as medicine, especially in reproductive healing.

9) Cow milk (Cow's milk):
Cow's milk is utilized in the preparation of phalaghrita as a cooking medium, enriching the formulation with nutrients beneficial for health. Its inclusion is grounded in Ayurvedic principles that highlight dairy as a source of nourishment and support for bodily systems, particularly in enhancing reproductive function.

10) Dysmenorrhea (Dysmenorrhoea):
Dysmenorrhoea refers to painful menstruation, a common symptom in many women facing infertility. This study documented such symptoms to evaluate the overall effectiveness of phalaghrita. Addressing dysmenorrhoea not only improves quality of life but also plays an integral role in the broader context of female reproductive health.

11) Daruharidra (DÄruharidrÄ, Daru-haridra):
Daru-haridra, or Berberis aristata, is an Ayurvedic herb noted for its potential health benefits, including anti-inflammatory and detoxifying effects. Its presence in phalaghrita suggests its role in optimizing reproductive health, particularly in alleviating symptoms associated with female infertility and improving treatment outcomes.

12) Ghritapaka (Ghá¹›tapÄka, Ghrita-paka):
Ghrita-paka refers to the specific process of preparing ghee with herbs. This method is essential for enhancing the medicinal qualities of the ghee, ensuring that the therapeutic benefits of the ingredients are preserved and effectively delivered within the phalaghrita formulation, thus supporting fertility treatment.

13) Discussion:
The 'Discussion' section in clinical trials serves as a platform to interpret results, reflect on methodology, and compare findings with existing literature. Here, the efficacy of phalaghrita in treating infertility is critically analyzed, ensuring that conclusions drawn are substantiated and applicable within both traditional and modern medical paradigms.

14) Punarnava (PunarnavÄ, Punarṇava, Punar-nava):
Punarnava, known for its rejuvenating properties, plays a role in enhancing metabolism and promoting tissue healing. In the context of phalaghrita, it contributes to the overall effectiveness of the treatment for female infertility by supporting the reproductive system's health and potentially improving menstrual and ovulatory functions.

15) Shatavari (ÅšatÄvarÄ«, SatÄvarÄ«):
Satavari, or Asparagus racemosus, is revered in Ayurvedic medicine for its adaptogenic qualities that enhance reproductive health. Within phalaghrita, it likely aids in hormone regulation, making it a vital ingredient for addressing female infertility and improving overall vitality and reproductive wellness among women.

16) Snehana:
Snehana, or the process of oleation in Ayurveda, is critical for providing nourishment and softness to the body tissues. In infertility treatments, snehana supports the reproductive organs, promoting better blood flow and hormonal balance, and is emphasized through the use of ghee based formulations like phalaghrita.

17) Tarpana (Tarpaṇa):
Tarpana refers to the act of nourishing or satiating, particularly in relation to tissues and organs. Its significance in the context of phalaghrita denotes the intention to nourish the endometrium, enhancing its receptivity and viability for conception. This concept is foundational to Ayurvedic reproductive health.

18) Shyonaka (ÅšyonÄka, ÅšyoṇÄka, SyonÄka):
Syonaka, or Oroxylum indicum, is an herb acknowledged for its medicinal properties, including its effects on digestive health and detoxification. Its inclusion in phalaghrita is aimed at supporting overall wellness and potentially enhancing fertility by promoting a balanced internal environment conducive to reproductive success.

19) Yantra (Yamtra):
In this context, a 'yantra' refers to the device or apparatus used for the intrauterine insufflation (uttaravasti) of phalaghrita. The design and application of this device are essential for ensuring correct administration, enhancing the effectiveness of the treatment, and minimizing any discomfort for the patient during the procedure.

20) Shalya (Åšalya, Salya):
Shalya is a branch of Ayurvedic medicine focused on surgery and trauma management. Its mention in the clinical trial emphasizes the interdisciplinary approach needed in addressing complex health issues like infertility, wherein surgical options or interventions may be necessary alongside herbal treatments for optimal outcomes.

21) Uttara (UttÄra, UttarÄ, Uá¹­á¹­ÄṟÄ�):
Uttara refers to the specific method of administration known as 'uttaravasti,' where the herbal preparation is insufflated in the uterus. This approach underscores the application of localized treatments in Ayurveda, which aims to address reproductive health concerns directly at the site of issue, maximizing therapeutic effects.

22) Cancer:
In the study, cancer is mentioned as an exclusion criterion for participants, underscoring the importance of screening for serious underlying conditions when researching treatments for infertility. This recognition highlights the necessity of patient safety and the relevance of thorough clinical assessments before pursuing alternative therapies.

23) Karma (Karman, KÄrma):
Karma, in the context of Ayurveda, refers to the actions and treatments one undergoes, which include both procedural and philosophical aspects of healing. It denotes the holistic approach in infertility management, where the treatment's success is linked not only to the medicine used but also to overall lifestyle changes.

24) Vidhi:
Vidhi refers to the specified methodology or process followed in administering treatments like phalaghrita. This term emphasizes the importance of adhering to correct procedures in Ayurvedic practices, ensuring the efficacy and safety of herbal medicines when applied in clinical settings.

25) Rasna (RÄsnÄ, Rashna, Rasona, Rasa-una):
Rasna, or Alpinia galanga, is an herb valued for its properties in alleviating pain and inflammation. Its inclusion in phalaghrita reflects the range of herbal ingredients aimed at supporting reproductive health by targeting discomfort and discomfort-related conditions commonly associated with infertility.

26) Musta (MustÄ, Muṣṭa, Mushta):
Musta, or Cyperus rotundus, is used for its digestive and endocrine-supporting properties in Ayurvedic formulations. Within phalaghrita, musta plays a role in promoting hormonal balance and overall reproductive health, thereby contributing positively to the treatment outcomes for women experiencing infertility.

27) Lemon:
Lemon juice is listed as a preparatory ingredient for phalaghrita and is known for its detoxifying properties. Its presence in formulations highlights the Ayurvedic belief in the significance of balancing different tastes and enhancing absorption of the herbal constituents, thus supporting overall health, including reproductive functions.

28) Roga:
Roga, meaning disease or disorder in Sanskrit, encompasses the ailments being addressed through treatment. The study's concentration on stree roga, particularly infertility, emphasizes the holistic Ayurvedic perspective that categorizes health issues based on their symptoms and treats them through natural and traditional methods.

29) Ritu (Ṛtu):
Ritu refers to the menstrual cycle or period in women, significant in determining reproductive health and fertility. Understanding the importance of ritu in Ayurveda helps practitioners align treatments with the natural rhythms of the body, thus enhancing the effectiveness of interventions like phalaghrita in addressing infertility.

30) Daru (DÄru):
Daru signifies 'wood' in Sanskrit, referring to the source of herbs like daru-haridra. This term highlights the connection between plant-based medicines derived from natural environments and their usage in traditional therapies, illustrating Ayurveda's reliance on botanical sources for treating complex health conditions like infertility.

31) Medas (Meda, MedÄ, Medash):
Meda typically refers to body fat or adipose tissue in Ayurvedic texts. Its consideration in fertility treatments indicates the relevance of body composition and nutritional status in women's reproductive health, reflecting Ayurvedic principles that advocate for balanced body conditions to support conception and overall well-being.

32) Paka (PÄka, PakÄ, PÄkÄ):
Paka refers to the cooking process in Ayurvedic formulations, particularly related to the preparation of ghrita with herbs. This term reflects the traditional practices aimed at extracting active compounds, ensuring potency, and maximizing therapeutic benefits, which are essential in formulating effective treatments like phalaghrita.

33) Ambu (Aṃbu):
Ambu, meaning water in Sanskrit, is crucial in the context of herbal preparations where maintaining moisture and balance is vital. In formulations like phalaghrita, ambu plays a role in the cooking process, facilitating the extraction of benefits from herbs while preserving their efficacy through proper hydration.

34) Milk:
Milk serves as an important ingredient in preparing phalaghrita, enhancing its nutritional profile. Its inclusion not only provides essential nutrients but also aligns with Ayurvedic beliefs on nourishing substances, supporting healthy reproductive functions, and accentuating the necessity of dairy in treatments aimed at improving women's overall health.

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Discover the significance of concepts within the article: �Clinical trial of phalaghrita on female infertility�. Further sources in the context of Science might help you critically compare this page with similair documents:

Exclusion criteria, Lower abdominal pain, Female infertility, P Value, Selection criteria, Clinical assessment, Improvement percentage, Hysterosalpingography, Amenorrhoea, Subjective Criteria, Objective Criteria, Endometrial biopsy, Treatment of infertility, Statistically analysed, Aetiological factor.

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