Estrous cycle periodicity in albino rats and drug combination effects.
Journal name: Ancient Science of Life
Original article title: Periodicity of estrous cycle in albino rats; response to some crude drug combinations
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
C. K. Kokate, M. Krishna Reddy, N. Chari
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Periodicity of estrous cycle in albino rats; response to some crude drug combinations
Year: 1987
Copyright (license): CC BY-NC-SA
Download the PDF file of the original publication
Summary of article contents:
Introduction
The study investigates the antifertility effects of various combinations of plant extracts on the estrous cycle of female albino rats, essential for understanding the potential of natural products as contraceptives in Indian medicine. The research focuses on the extracts from Azadirachta indica, Piper longum, Emblica officinalis, and Gossypium indicum, exploring how these combinations might affect the estrous cycle phases. While individual antifertility effects of these plants have been documented, their combined effects remain under-researched, prompting this study.
Effects on the Estrous Cycle
The research revealed that one of the combinations, particularly Combination (B), significantly prolonged the diestrous phase of the estrous cycle in the rats. This alteration suggests a weak estrogenic effect, as indicated by the increased duration of the leucocytic stage. The average durations for the proestrous, estrous, metaestrous, and diestrous phases were documented in a comparative table, highlighting that combinations (A) and (C) did not yield considerable effects. Importantly, no adverse impact on the overall body weight of the rats was observed, reinforcing the safety profile of these crude drug combinations when administered at the tested dosage.
Conclusion
The findings from this study underscore the potential of specific combinations of natural plant extracts to influence reproductive cycles in female albino rats. Particularly, the effective prolongation of the diestrous phase could pave the way for further investigation into these combinations' estrogen-like activities. Such studies may enrich the understanding of plant-based contraceptive methods and their applications in traditional medicine, while also calling for a deeper exploration of the mechanisms behind the observed effects on the estrous cycle.
FAQ section (important questions/answers):
What was the aim of the study on albino rats?
The study aimed to observe the effects of combinations of crude drug extracts on the estrous cycle of female albino rats, specifically focusing on any potential antifertility activities.
What combinations of extracts were tested in the research?
Three combinations were tested: Combination (A) included extracts from A. indica, P. longum, and G. indicum; Combination (B) involved similar extracts with E. officinalis; and Combination (C) included extracts from A. indica, E. officinalis, G. indicum, and P. longum.
What significant result was found regarding the estrous cycle?
Combination (B) showed a considerable prolongation of the diestrous phase compared to the normal cycle, indicating a potential weak estrogenic effect from the herbal combinations.
Did the drug combinations affect the body weight of rats?
No adverse effects on body weight were observed in the animals after treatment with the different combinations of crude drug extracts during the study.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Estrous cycle periodicity in albino rats and drug combination effects.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
Keyword refers to substances used for medical treatment, particularly to influence biological processes in living organisms. In this context, various plant-derived extracts are studied for their potential effects on the estrous cycle of female albino rats, showcasing a focus on alternative therapies in fertility regulation.
2) Activity:
This term denotes the biological effects elicited by a substance, particularly in a pharmacological context. The study highlights the antifertility activity of certain plant extracts, indicating their role in modifying estrous cycles, which could contribute to the understanding of plant-based contraceptives and their mechanisms of action.
3) Science (Scientific):
Science represents a systematic enterprise that builds and organizes knowledge through observation and experimentation. In this study, scientific methodologies are employed to investigate the effects of crude drug combinations, grounding the findings in empirical evidence and enhancing the validity of traditional medicinal claims through rigorous research.
4) Azadirachta indica:
Commonly known as neem, this plant is highlighted for its medicinal properties, particularly in Indian herbal medicine. The study examines its extracts as part of a combination treatment aimed at influencing the estrous cycle, illustrating the significance of indigenous plants in pharmacological research.
5) Piper longum:
Known as long pepper, this species is recognized for its therapeutic uses in traditional medicine. Its inclusion in the study, as part of the crude drug combinations, exemplifies efforts to explore diverse natural products for potential reproductive health applications and their roles in influencing hormonal activities.
6) Discussion:
This section allows for interpretation and analysis of experimental findings. The discussion reflects on the observed effects of the plant extracts on the estrous cycle, examining the implications of these findings for further research and potential applications in fertility management or alternative contraception strategies.
7) Medicine:
Medicine signifies the field focused on health and disease, inclusive of various treatment methods. In this research, the exploration of plant extracts as alternative medicinal agents provides insights into traditional practices while bridging them with modern scientific methodologies aimed at developing effective health interventions.
8) Krishna (Kṛṣṇ�, Kṛṣṇa):
In this context, Krishna Reddy is one of the authors involved in the research. This highlights the collaborative nature of scientific studies, where multiple researchers contribute to the advancement of knowledge, specifically in pharmacological investigations concerning the effects of natural products on biological systems.
Other Science Concepts:
Discover the significance of concepts within the article: �Estrous cycle periodicity in albino rats and drug combination effects.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Control group, Experimental group, Body weight, Estrous cycle, Maceration technique, Vaginal smear, Haematoxylin and eosin, P. longum, Albino rat, Estrogen, E. officinalis, Diestrous phase, Alkaloid extract, Gonadotropin.