Significance of Tumor necrosis factor-alpha
Tumor necrosis factor-alpha (TNF-伪) is a key pro-inflammatory cytokine involved in systemic inflammation and immune responses. It plays significant roles in various pathological conditions such as mucositis, periodontitis, and cancer. TNF-伪 is produced by macrophages and influences the inflammatory process by regulating other cytokines. Elevated levels are noted in conditions like obesity and chronic inflammatory disorders, including rheumatoid arthritis. Its dual role in tumor development highlights its importance in both promoting inflammation and mediating immune responses.
Synonyms: Tnf-alpha, Tumor necrosis factor
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The concept of Tumor necrosis factor-alpha in scientific sources
Tumor necrosis factor-alpha is a pro-inflammatory cytokine crucial in immune responses, linked to mucositis, synthesized by macrophages, involved in autoimmune diseases, and plays a role in systemic inflammation and the acute phase response.
From: The Malaysian Journal of Medical Sciences
(1) Tumor necrosis factor-alpha, also known as TNF-伪, is an inflammatory marker and cytokine, which has been found to be elevated in obesity and has a significant impact on insulin sensitivity.[1] (2) A cytokine involved in systemic inflammation, serving as a key regulator in immune responses and a determinant of pathogenesis in infections.[2] (3) A significant cytokine involved in inflammation and immune responses relevant to mycobacterial CNS infections.[3]