Significance of Robustness
Robustness refers to the ability of an analytical method to remain unaffected by small variations in method parameters, ensuring consistency and reliability during analysis. This includes resistance to minor changes in conditions such as flow rate, temperature, or solvent composition. Robustness is crucial for confirming the reliability and stability of analytical methods across different experimental situations. It is assessed during method validation, highlighting the method's dependable performance despite small, deliberate variations in its parameters.
Synonyms: Durability, Strength, Resilience, Reliability
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The concept of Robustness in scientific sources
Robustness measures an analytical method's reliability and consistency by demonstrating its resilience to minor, unintentional or intentional variations in method parameters, ensuring dependable outcomes under varying conditions.
From: World Journal of Pharmaceutical Research
(1) A measure of the method's ability to remain unaffected by small, deliberate variations in method parameters.[1] (2) The ability of a method to remain unaffected by small variations in method parameters.[2] (3) The method's ability to remain unaffected by small, deliberate variations in experimental parameters.[3] (4) The capacity of the analytical method to remain unaffected by small variations in method parameters, ensuring reliable results under diverse conditions.[4] (5) The ability of a method to remain unaffected by small variations in method parameters.[5]