Evaluation of acute dermal irritation, sensitization, and in-vitro anti-inflammatory activity of cannabis-based pain-relieving topical oil � cannaquictm
Journal name: International Ayurvedic Medical Journal
Original article title: Evaluation of acute dermal irritation, sensitization, and in-vitro anti-inflammatory activity of cannabis-based pain-relieving topical oil � cannaquictm
The International Ayurvedic Medical Journal (IAMJ) is a peer-reviewed scientific publication dedicated to Ayurveda. It aims to integrate Ayurvedic concepts with modern scientific understanding, offering a comprehensive source of validated knowledge for both the modern Ayurvedic community and the broader medical fraternity.
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Mohanty Nilima
Agarwal Sourab
Sarangi Diptimayee. Mishra Rajan K
International Ayurvedic Medical Journal:
(Publishing full-length original papers and reviews on ayurveda)
Full text available for: Evaluation of acute dermal irritation, sensitization, and in-vitro anti-inflammatory activity of cannabis-based pain-relieving topical oil � cannaquictm
Year: 2023
Copyright (license): CC BY-NC-ND 3.0
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Summary of article contents:
Cannabis is known and considered a sacred plant because of its analgesic, antiinflammatory, and stimulating properties. Other herbs like Shallaki, Bala, Nirgundi, Kantakari, and Kupilu are also known as medicinal herbs and have tremendous painrelieving properties. Objectives: A formulation with an infusion of cannabis leaves extract and other herbs in sesame oil can be a good therapy for relieving different types of pain when applied topically. An evaluation study was conducted in animals for the evaluation of dermal irritation, sensitization, and antiinflammatory properties. Methods: This study was designed to evaluate acute dermal irritation/corrosion, sensitization on skin and antiinflammatory activity of CannaquicTM according to OECD guidelines. No erythema, edema, or any skin lesion was observed after application. Results & Conclusion: The results revealed no irritation/corrosion from CannaquicTM. Invitro Anti-Inflammatory activity against LPS-induced toxicity in Mouse Macrophage (RAW 264.7) cell line exhibits a significant percentage reduction in IL-6, Nitric Oxide (NO), and TNF-alpha in Mouse Macrophage (RAW 264.7) cellline against LPS-induced inflammation. Keywords: Pain relieving oil, Cannabis sativa, Preclinical trial, Antiinflammatory INTRODUCTION Pain is often described as an unpleasant sensory and emotional experience associated with actual or potential tissue damage
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Cannabis sativa, Nervous system, Anti-inflammatory activity, Ayurvedic text, Acute dermal irritation, Skin sensitization test, Preclinical trial, Non-toxic concentration, Cannabinoid receptors, Herbal oil, OECD Guideline.