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Standardization and evaluation of three Aśvagandhādyariṣṭa brands

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Journal name: Ancient Science of Life
Original article title: Physicochemical standardization, HPTLC profiling, and biological evaluation of Aśvagandhādyariṣṭa: A comparative study of three famous commercial brands
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Mandeep Singh, Navdeep Kaur, Atish Tulsiram Paul


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Physicochemical standardization, HPTLC profiling, and biological evaluation of Aśvagandhādyariṣṭa: A comparative study of three famous commercial brands

Year: 2014

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study focuses on the physicochemical standardization, high-performance thin-layer chromatography (HPTLC) profiling, and biological evaluation of Aśvagandhādyariṣṭa, a popular polyherbal formulation commonly used in traditional Indian medicine. Despite its widespread use, there has been a lack of comparative analysis concerning the quality and efficacy of commercially available brands of this formulation. The study analyzes three leading brands of Aśvagandhādyariṣṭa obtained from the market, investigating their physicochemical properties, antioxidant activity, and potential anthelmintic effects.

Anthelmintic and Antioxidant Activity

In assessing the biological effects, the research evaluated the anthelmintic potential of Aśvagandhādyariṣṭa using the earthworm Eisenia foetida as a test organism. The results indicated that one particular brand, ASA-DAB, exhibited the most significant anthelmintic activity compared to the others at various concentrations. Additionally, the study also explored the antioxidant properties of the formulations through DPPH and hydrogen peroxide scavenging assays. The findings highlighted that ASA-DAB demonstrated remarkable radical scavenging capabilities, suggesting its potential in combating oxidative stress. These results support the traditional claims of Aśvagandhādyariṣṭa being a nervine tonic and antistress formulation.

Conclusion

The investigation reveals that Aśvagandhādyariṣṭa possesses both antioxidant and anthelmintic functionalities, aligning with its traditional medicinal claims. However, the study identifies moderate variations in the physicochemical parameters across the brands, which can influence their biological profiles. Such discrepancies underline the need for rigorous quality control and standardization in herbal formulations. Further investigations are warranted to establish comprehensive standards for Aśvagandhādyariṣṭa to ensure consistent therapeutic efficacy and safety across its various commercial brands.

FAQ section (important questions/answers):

What is the main ingredient in Aśvagandhādyariṣṭa?

The main ingredient in Aśvagandhādyariṣṭa is Withania somnifera, a medicinal herb known for its various therapeutic properties.

How was the physicochemical standardization of Aśvagandhādyariṣṭa conducted?

The physicochemical standardization was carried out according to the Ayurvedic Pharmacopoeia of India, measuring parameters like total solids, pH, specific gravity, and alcohol content.

Which commercial brand of Aśvagandhādyariṣṭa showed the best anthelmintic activity?

The commercial brand ASA-DAB demonstrated the highest anthelmintic activity compared to ASA-BDN and ASA-AVP at a concentration of 200 mg/ml.

What methods were used to evaluate the antioxidant activity?

Antioxidant activity was evaluated using the DPPH scavenging assay and the hydrogen peroxide scavenging assay, highlighting the potential of each formulation.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Standardization and evaluation of three Aśvagandhādyariṣṭa brands�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the effectiveness of 'Aśvagandhādyariṣṭa' in various applications, such as its anthelmintic potential against worms and antioxidant properties. The study measures different activities scientifically, helping to validate traditional claims regarding this polyherbal formulation used in Ayurvedic medicine.

2) Water:
Water serves as a critical solvent and medium in the preparation and analysis of 'Aśvagandhādyariṣṭa.' The study emphasizes its role in sample preparation for physicochemical tests, which assess qualities like pH, specific gravity, and total solid content, aligning with standard pharmacological practices.

3) Science (Scientific):
Scientific describes the systematic approach taken in evaluating 'Aśvagandhādyariṣṭa.' By applying established methodologies, the research seeks to substantiatively validate claims of efficacy, bridging the gap between traditional uses and contemporary evidence-based medicine.

4) Quality:
Quality assessment is integral to ensuring the efficacy and safety of 'Aśvagandhādyariṣṭa.' The study performs physicochemical standardization in accordance with the Ayurvedic Pharmacopoeia, highlighting the importance of consistent manufacturing practices to meet established benchmarks and consumer confidence in traditional medicines.

5) Medicine:
Medicine encompasses the therapeutic uses of 'Aśvagandhādyariṣṭa' as a nervine tonic and antistress formulation in Ayurveda. The study explores its traditional applications, validating its role in health care and representing a blend of ancient wisdom and modern scientific inquiry.

6) Worm:
Worm refers to 'Eisenia foetida,' the test organism used in evaluating 'Aśvagandhādyariṣṭa' for anthelmintic activity. The formulation's ability to affect worms is significant, suggesting potential applications for treating helminthic infections, which are relevant to various gastrointestinal health issues.

7) Drug:
Drug relates to 'Aśvagandhādyariṣṭa' as an over-the-counter formulation in the context of Ayurvedic medicine. The study discusses its pharmacological properties and the regulatory aspects necessary for its classification and availability as a therapeutic agent in the market.

8) Sugar:
Sugar refers mainly to the reducing sugars present in 'Aśvagandhādyariṣṭa,' which are significant in determining the fermentation quality of the formulation. Understanding its sugar content aids in evaluating the metabolic processes and safety of the final product regarding Ayurvedic standards.

9) Withania somnifera:
Withania somnifera, the primary ingredient in 'Aśvagandhādyariṣṭa,' is renowned for its adaptogenic properties. The study highlights its therapeutic potential, including neuroprotective effects and stress reduction, underpinning the formulation's traditional health claims within Ayurveda.

10) Discussion:
Discussion in the context of the study involves analyzing results obtained from various tests to draw conclusions about the efficacy and quality of 'Aśvagandhādyariṣṭa.' It provides insights into the broader implications of the findings for future research and traditional medicine practices.

11) Psychosis:
Psychosis is one of the traditional health issues that 'Aśvagandhādyariṣṭa' aims to address, showcasing its historical relevance in treating mental health disorders. The study's exploration into its therapeutic effects emphasizes the formulation as a multifaceted remedy in Ayurveda.

12) Epilepsy:
Epilepsy represents another ailment for which 'Aśvagandhādyariṣṭa' is traditionally used. The formulation’s role in managing such neurological disorders adds depth to its therapeutic profile, as examined through both historical and empirical research in the study.

13) Jaggery:
Jaggery is noted for its role in the fermentation process of 'Aśvagandhādyariṣṭa.' The sugar content and quality of jaggery directly influence the efficacy and safety of the final product, highlighting the importance of sourcing and standardization in herbal preparations.

14) Arjuna:
Arjuna (Dr. Ananya Arjuna) is recognized for their contribution to the study, particularly in microbial limit tests. Their involvement underscores the collaborative efforts required in researching traditional medicine while maintaining rigorous scientific standards.

15) Vaidya:
Vaidya signifies traditional practitioners of Ayurveda, reflecting the integration of age-old medicinal wisdom in formulating products like 'Aśvagandhādyariṣṭa.' This term links the historical context to modern scientific studies aimed at validating traditional approaches.

16) Arishta (Arista):
ṣṭ refers to a specific class of Ayurvedic fermented herbal preparations like 'Aśvagandhādyariṣṭa.' Understanding ṣṭ formulations involves studying their medicinal properties, preparation methods, and traditional uses, which are central to Ayurvedic therapeutic practices.

17) Reason:
Reason signifies the logical framework guiding the investigation of 'Aśvagandhādyariṣṭa.' It relates to understanding the formulation’s claimed health benefits and prompting further exploration into its therapeutic applications and overall efficacy in healthcare.

18) Shri (Sri, Sr):
Shree represents respect and reverence in Indian culture, often associated with institutions or individuals, such as 'Shree Baidyanath Ayurved Bhawan Pvt. Ltd.' This highlights the significance of well-established entities in the production of trusted Ayurvedic formulations.

19) Salt (Salty):
Salt may refer to the mineral content in Ayurvedic formulations. While not directly mentioned in the study, understanding its role in health and homemade remedies could inform the broader context of traditional medicine, where salt balance may affect efficacy.

Other Science Concepts:

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Discover the significance of concepts within the article: �Standardization and evaluation of three Asvagandhadyarista brands�. Further sources in the context of Science might help you critically compare this page with similair documents:

Statistical analysis, High performance thin layer chromatography, Ayurvedic Pharmacopoeia of India, Total phenolic content, Anthelmintic activity, Total solid content, 1,1-diphenyl-2-picrylhydrazyl, Biological evaluation, Hydrogen peroxide scavenging, Microbial limits, Physicochemical standardization.

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