Antioxidant potential and phenolic content of Madhuca indica bark extract.
Journal name: Ancient Science of Life
Original article title: Antioxidant potential and total phenolic content of methanolic bark extract of Madhuca indica (koenig) Gmelin
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Anu Chaudhary, Anil Bhandari, A. Pandurangan
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Antioxidant potential and total phenolic content of methanolic bark extract of Madhuca indica (koenig) Gmelin
Year: 2012
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
This study investigates the antioxidant potential and total phenolic content of the methanolic extract of Madhuca indica (commonly known as mahua) bark. The research emphasizes the significance of natural antioxidants in combating oxidative stress, which is a major contributor to various chronic diseases. The authors conducted multiple assays, including DPPH radical, superoxide anion radical, nitric oxide radical, hydroxyl radical, and lipid peroxidation to evaluate the effectiveness of the extract in scavenging free radicals.
Antioxidant Activity of Madhuca indica Bark Extract
The findings reveal that the methanolic extract of Madhuca indica displays significant antioxidant activity across various models. For example, it exhibited a notable inhibition of DPPH radicals, with a 74.1% scavenging effect at a concentration of 40 μg/ml, showcasing strong hydrogen-donating capabilities. The study also reported a concentration-dependent increase in the scavenging effect of nitric oxide and superoxide radical, with respective IC50 values of 192.8 μg/ml and 38.1 μg/ml. Moreover, the extract demonstrated effective inhibition of lipid peroxidation, highlighting its potential protective role against oxidative damage.
Conclusion
The results of this study confirm that the methanolic extract of Madhuca indica possesses significant antioxidant properties, likely attributed to its high content of phenolic compounds. These preliminary findings support the traditional use of Madhuca indica in folk medicine for its antioxidant effects. Further investigation, particularly in vivo studies, is encouraged to explore the extract's potential therapeutic applications and to isolate the active compounds responsible for its antioxidant activity.
FAQ section (important questions/answers):
What is the antioxidant potential of Madhuca indica bark extract?
The methanolic extract of Madhuca indica bark demonstrates significant antioxidant activity by scavenging various free radicals, such as DPPH, nitric oxide, and hydroxyl radicals, in a concentration-dependent manner.
What methods were used to evaluate the antioxidant activity?
The study utilized several assays, including DPPH radical scavenging, nitric oxide radical inhibition, superoxide anion scavenging, lipid peroxidation inhibition, and total phenolic content determination to assess the antioxidant potential of the extract.
What compounds contribute to the antioxidant properties of the extract?
The high antioxidant activity of Madhuca indica is attributed to its phenolic compounds, which possess hydroxyl groups that enable them to act as hydrogen donors, effectively scavenging free radicals.
What are some traditional uses of Madhuca indica in folk medicine?
In folk medicine, Madhuca indica is utilized for various ailments, including treatments for itching, swellings, fractures, snake bites, and diabetes mellitus, indicating its potential therapeutic properties.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antioxidant potential and phenolic content of Madhuca indica bark extract.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Antioxidant activity refers to the capacity of substances to inhibit oxidation, a process that can lead to cellular damage. In the study of Madhuca indica, various assays demonstrated significant free radical scavenging activity, indicating its potential therapeutic benefits in diseases related to oxidative stress such as cancer.
2) Madhuca indica:
Madhuca indica, commonly known as Mahua, is a significant plant studied for its medicinal properties. The methanolic extract of its bark revealed strong antioxidant properties, making it a subject of interest in medicine for various health conditions including cancer and oxidative stress-related diseases.
3) Mahua:
Mahua is a local name for Madhuca indica, a plant used in traditional medicine. Its bark extract shows promising antioxidant and medicinal properties, providing benefits in treating ailments such as swelling and itching, which are common symptoms in various conditions including cancer.
4) Discussion:
The discussion in the study highlights the relevance of the antioxidant properties of Madhuca indica. It outlines how these properties could play a role in preventing diseases such as cancer, emphasizing the importance of further research and understanding of medicinal plants in modern science.
5) Flavonoid:
Flavonoids are a class of polyphenolic compounds known for their antioxidant properties. The bark of Madhuca indica contains various phytochemicals, including flavonoids, which contribute to its medicinal uses in combating oxidative stress and inflammation associated with diseases like cancer.
6) Medicine:
Medicine is the science and practice aimed at maintaining or restoring health. The study showcases Madhuca indica's potential as a medicinal plant due to its significant antioxidant activity, which can help manage conditions like cancer and other disorders caused by oxidative stress.
7) Swelling:
Swelling is a common symptom associated with inflammation and various medical conditions. In folk medicine, extracts from Madhuca indica are used to alleviate swelling, illustrating the traditional knowledge of medicinal plants in treating ailments effectively.
8) Itching:
Itching is an unpleasant sensation that can be symptomatic of skin conditions or other ailments. The bark of Madhuca indica has been traditionally used to relieve itching, supporting its role in herbal medicine and demonstrating its therapeutic properties against various skin irritations.
9) Science (Scientific):
Science refers to the systematic study of the structure and behavior of the physical and natural world. The research focused on Madhuca indica exemplifies the application of scientific methods to uncover the antioxidant and potential medicinal properties of this plant, contributing to our understanding of natural products in medicine.
10) Cancer:
Cancer is a leading cause of death, often linked to oxidative stress and inflammation. The antioxidant activity of Madhuca indica suggests that its extracts may play a role in fighting cancer by combating free radicals and providing protective effects against oxidative damage.
11) Botany:
Botany is the scientific study of plants. The research on Madhuca indica involves understanding its botanical aspects, including its phytochemical constituents and their roles in traditional medicine, thereby enriching the field of botany with practical applications in healthcare.
12) Water:
[see source text or glossary: #Water#]
13) Sugar:
[see source text or glossary: #Sugar#]
14) Ulcer:
Ulcers are sores that can form on the skin or mucous membranes, often requiring medical treatment. The traditional use of Madhuca indica includes applications for ulcers, illustrating its historical and ongoing relevance in medicinal practices for promoting healing and reducing symptoms in various conditions.
15) Salt (Salty):
[see source text or glossary: #Salt#]
Other Science Concepts:
Discover the significance of concepts within the article: �Antioxidant potential and phenolic content of Madhuca indica bark extract.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Madhuca indica, Antioxidant activity, Lipid peroxidation, Free radical scavenging activity, Total phenolic content, IC50 value, Nitric oxide radical, Soxhlet Apparatus, DPPH radical, Hydroxyl radical, Superoxide anion radical.