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Study on "Bala compound's" immunoglobulin effect in infants

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Journal name: Ancient Science of Life
Original article title: Clinical study of the Immunoglobululin Enhancing effect of “Bala compound� on Infants
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

Dr. Rao R. Appaji, Dr. R.D. Sharma, G. P. Katiyar, Dr. Prasad A.J.V. Sai


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Clinical study of the Immunoglobululin Enhancing effect of “Bala compound� on Infants

Year: 2009

Copyright (license): CC BY-NC-SA


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Summary of article contents:

Introduction

The study investigates the role of immunoglobulins—specifically IgG, IgM, and IgA—in enhancing the immunity of infants, particularly focusing on the 'Bala compound' derived from various Ayurvedic herbs. Infants are particularly vulnerable to infections due to their immature immune systems, making the exploration of traditional remedies crucial, especially in developing countries where infant mortality rates are significantly higher. The research aims to evaluate the efficacy of the 'Bala compound' in bolstering immunoglobulin levels in infants compared to conventional multivitamin drops.

The Concept of Vyadhikshamatva and Ojas

A critical concept discussed is 'vyadhikshamatva,' which refers to the resistance against disease and is closely aligned with the modern understanding of immunology. In Ayurvedic terms, 'Ojas' represents the inherent vitality and immunity of the body, which can be diminished by various factors. The study elucidates how the 'Bala compound,' containing several medicinal herbs known for their rejuvenating properties, can enhance both Ojas and Bala (strength), thereby potentially improving the overall immunity of infants. The evaluation of IgG, IgM, and IgA levels in infants receiving the 'Bala compound' showed a significant increase after six months of administration, reinforcing the traditional belief in the compound’s effectiveness.

Conclusion

The findings of this study underscore the potential of integrating Ayurvedic remedies with modern immunological understanding in the pursuit of improving infant health. The significant increase in immunoglobulin levels among infants treated with the 'Bala compound' highlights its role in enhancing immunity and addressing the high infant mortality rates attributed to infections in developing countries. Future clinical trials with larger sample sizes will be essential to further establish the safety and efficacy of the 'Bala compound' as a valuable intervention in neonatal healthcare, particularly for those vulnerable to infectious diseases.

FAQ section (important questions/answers):

What is the purpose of the 'Bala compound' in infants?

The 'Bala compound' aims to enhance immunoglobulin levels in infants, particularly aiding their immune system, which is not fully functional at birth. This can potentially reduce susceptibility to infections and the overall infant mortality rate in developing countries.

How does maternal immunoglobulin affect infants at birth?

Maternal immunoglobulin, especially IgG, crosses the placenta and is present in umbilical cord blood. This provides initial immune protection to the newborn, which is crucial given their immature immune system, leading to higher vulnerability to infections.

What were the main findings of the clinical study?

The study indicated that the 'Bala compound' significantly increased serum levels of immunoglobulins IgG, IgM, and IgA in infants compared to conventional multivitamin drops, suggesting its effectiveness in enhancing immune responses in neonates.

What immunoglobulin levels were monitored in this study?

The study monitored immunoglobulin levels of IgG, IgM, and IgA at baseline and after six months of administration of 'Bala compound', revealing significant enhancements, which play a critical role in the infant's resistance to infections.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study on "Bala compound's" immunoglobulin effect in infants�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Bala:
Bala, meaning 'infant' or 'child,' represents the vulnerable stage of human life where immunity is underdeveloped. In Ayurveda, it emphasizes the importance of nurturing and strengthening children to combat potential diseases and environmental challenges. 'Bala' is intrinsic to the Ayurvedic concept of protecting and enhancing children's health.

2) Blood:
Blood serves as a vital component in the study of immunoglobulins, specifically maternal and neonatal blood. It carries immunoglobulins like IgG, IgM, and IgA, crucial for immunity. In the context of the clinical study, blood samples offer critical data for assessing the efficacy of 'Bala compound' in enhancing immunological defenses in infants.

3) Drug:
In this study, 'Bala compound' is the focus as a medicinal preparation aimed at enhancing immunity in infants through a mix of Ayurvedic herbs. The classification of 'Bala' as a drug aligns with Ayurvedic principles where herbal formulations are used to strengthen health and combat diseases during critical periods of life.

4) Sharman (Sarma, Sharma, Sarman):
Sharma likely refers to one of the authors or experts involved in the study. In the context of Ayurveda, individuals with the surname Sharma are often scholars or practitioners. Their involvement adds credibility to the research, representing a tradition of knowledge in Ayurveda and its application in modern health challenges.

5) Science (Scientific):
Science in this context refers to the systematic study and evaluation of the 'Bala compound' and its effects on immunoglobulin levels in infants. It embodies a blend of traditional Ayurvedic wisdom and modern scientific methodologies aimed at verifying the effectiveness and safety of herbal treatments in health care.

6) Ojas:
Ojas is a key concept in Ayurveda representing vitality and immunity. It is believed to be a result of proper digestion and a balanced lifestyle. In the context of infant health, enhancing Ojas is essential for resistance to diseases, making it a critical component in nurturing children's immunity.

7) Samhita:
Samhita refers to classical texts in Ayurveda that compile medical knowledge, treatments, and philosophies. It signifies the traditional foundation supporting Ayurvedic medicine. In the study, references to Samhitas imply the research is rooted in traditional texts, employing centuries-old wisdom to address contemporary health issues in infants.

8) Vidanga (Vidamga):
Vidanga (Embelia ribes) is one of the herbs included in the 'Bala compound.' It is known for its medicinal properties, particularly in digestion and detoxification. Its inclusion in the formulation suggests its role in enhancing overall health and contributing to the strengthening of the immune system in newborns.

9) Tantra (Tamtra, Tantrism):
In this context, tantra refers to the branches of Ayurvedic knowledge or specific disciplines within Ayurveda. It suggests a focused approach on practices aimed at achieving health objectives. The study's grounding in tantra signifies the application of specialized Ayurvedic principles in understanding and promoting infant health.

10) Tinospora cordifolia:
Tinospora cordifolia, commonly known as Guduchi, is included in the 'Bala compound' for its reputed immunomodulatory effects. It is valued in Ayurveda for boosting immunity and acting against pathogens. Its incorporation in the study signifies the emphasis on using traditional herbs to enhance children's health and resilience.

11) Emblica officinalis:
Emblica officinalis, or Amalaki, is a key herb in Ayurveda widely recognized for its high vitamin C content and role in enhancing immunity. Its presence in 'Bala compound' not only provides antioxidant properties but also supports overall health in infants, aligning with the study's aim to improve immunological responses.

12) Glycyrrhiza glabra:
Glycyrrhiza glabra, known as Yashtimadhu, is included for its soothing and anti-inflammatory properties. In Ayurvedic practices, it helps in enhancing the overall health and well-being of infants. Its role in 'Bala compound' signifies the holistic approach of Ayurveda in promoting immunity and nurturing children's health.

13) Piper longum:
Piper longum, or Pippali, is known for its ability to enhance digestion and respiratory function. In the formulation of 'Bala compound,' Pippali's inclusion suggests its potential to improve nutrient absorption, thereby indirectly supporting the immune system of infants and promoting robust health during early stages of life.

14) Acorus calamus:
Acorus calamus, also known as Vacha, is recognized in Ayurveda for its cognitive benefits and ability to enhance digestive fire. Its addition to 'Bala compound' aligns with the study's goal of providing comprehensive health support to infants, including their cognitive and digestive capacities alongside immunological enhancement.

15) Ativisa (Ativisha):
Ativisha (Aconitum heterophyllum) is known for its powerful medicinal properties in Ayurveda, particularly in treating various ailments and improving digestion. Its use in 'Bala compound' suggests a focus on fortifying health and enhancing immune responses in infants, crucial for their development and resistance against infections.

16) Rasayana (Rasa-ayana):
Rasayana refers to rejuvenating therapies in Ayurveda aimed at restoring health and vitality. The inclusion of Rasayana herbs like those in 'Bala compound' underscores the goal of fostering long-term health and immunity in infants, cultivating a robust foundation for their growth and development.

17) Amalaki:
Amalaki, or Emblica officinalis, is renowned for its health benefits, including enhancing immunity and acting as an antioxidant. Its significant presence in 'Bala compound' emphasizes the intention to fortify the immune systems of infants, assuring better health outcomes during vulnerable developmental stages.

18) Atibala:
Atibala (Abutilon indicum) is recognized in Ayurvedic practices for its health-enhancing qualities, particularly in promoting strength and vitality. Its inclusion in the 'Bala compound' reflects the holistic Ayurvedic approach to enhancing children's health, focusing on building resilience against diseases from an early age.

19) Pippali (Pippalin):
Pippali (Piper longum) serves to enhance digestion and boost metabolism. Its incorporation in 'Bala compound' suggests a dual role in improving overall nutrient utilization while supporting the immune system, signifying a comprehensive approach to health enhancement in infants under modern clinical scrutiny.

20) Vyadhin (Vyadhi):
Vyadhi translates to 'disease' in Ayurveda and encompasses various disorders. The focus of the study is on the prevention of disease in infants through the enhancement of immunological factors. Understanding vyadhi is crucial for Ayurvedic practitioners in addressing and mitigating health challenges faced by neonates.

21) Musta (Mushta):
Musta (Cyperus rotundus) is included for its medicinal benefits, particularly in digestion and detoxification. Its role in the 'Bala compound' underscores the importance of a holistic approach in Ayurveda to boost infant health, focusing on both immunity and digestive strength, essential for overall well-being.

22) Vaca:
Vacha (Acorus calamus) is used for its cognitive enhancing abilities and digestive benefits in Ayurveda. Its inclusion in 'Bala compound' highlights the objective of not only boosting immunity but also supporting cognitive development in infants, crucial during their formative years.

23) Roga:
Roga refers to 'disease' or 'ailment' in Ayurveda. The study emphasizes combating roga through the enhancement of immune functions in infants, addressing the high infant mortality rate related to infections. Understanding roga aids practitioners in devising effective treatments for protecting neonatal health.

24) Cyperus rotundus:
Cyperus rotundus, known as Musta, is an important herb in Ayurveda recognized for its therapeutic properties, particularly in digestion and respiratory health. Its contribution to the 'Bala compound' reinforces the emphasis on promoting holistic health, essential for developing a robust immune system in infants.

25) Kashyapasamhita (Kasyapasamhita, Kashyapa-samhita):
Kashyapa-samhita is an ancient Ayurvedic text focusing on the health of infants and children. Its relevance to the study indicates a commitment to integrating traditional Ayurvedic knowledge with modern clinical practices, valuing long-standing wisdom in addressing pediatric health issues and enhancing immunity.

26) Sushruta-samhita (Susruta-samhita):
Susruta-samhita is a foundational text in Ayurveda, outlining surgical techniques and treatments. Its mention underscores the depth of Ayurvedic knowledge that informs the research, combining various aspects of traditional medicine for enhancing health outcomes, particularly concerning infant mortality rates.

27) Kaumarabhritya (Kaumarabhrtya, Kaumara-bhritya):
Kaumara-bhritya is the branch of Ayurveda specializing in pediatrics and child health. It is directly relevant to the study's focus, aimed at improving the health of infants through enhanced immunity and wellness products, reflecting the significance of specialized knowledge in addressing children's health care.

28) Vyadhikshamatva (Vyadhiksamatva):
Vyadhikshamatva refers to the concept of disease resistance or the ability to withstand illnesses. The study's focus on enhancing vyadhikshamatva through 'Bala compound' signifies the goal of improving overall health and immunity in infants, reducing susceptibility to infections.

29) Shankhapushpi (Sankhapuspi, Samkhapuspi):
Shankhapushpi (Convolvulus pluricaulis) is valued in Ayurveda for its cognitive-enhancing properties and its role in nurturing intellect. Its inclusion in 'Bala compound' signifies the holistic approach of the formulation, supporting cognitive functions alongside immune enhancement in early childhood development.

30) Embelia ribes:
Embelia ribes, or Vidanga, is a key ingredient in the 'Bala compound' known for its potential to assist digestion and elimination of toxins. Its contribution aligns with Ayurveda's holistic view of health, emphasizing the importance of digestive well-being for fostering robust immunity in infants.

31) Yashtimadhu (Yastimadhu, Yashti-madhu):
Yashtimadhu (Glycyrrhiza glabra) is recognized for its soothing and anti-inflammatory effects. In the context of 'Bala compound', its presence suggests an intention to enhance comfort and overall health in infants, supporting immune function and providing relief from various ailments encountered during early life.

32) Dravyaguna (Dravya-guna):
Dravya-guna refers to the study of herbal properties and effects in Ayurveda. This concept underlines the formulation of the 'Bala compound', reflecting the importance of understanding the characteristics of individual herbs used to create effective remedies for enhancing immunity in infants.

33) Discussion:
Discussion refers to the section of the research where results are interpreted and implications are drawn regarding the effectiveness of 'Bala compound'. This portion of the study highlights the relationship between the herbal formulation and the observed increases in immunoglobulin levels in infants.

34) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating from India, focusing on holistic health through natural remedies and lifestyle practices. The study draws from Ayurvedic principles to understand how traditional wisdom can contribute to modern health issues, particularly in improving immunity in infants.

35) Kashyapa (Kasyapa, Kashya-pa, Kashyapanamdana):
Kashyapa is a revered sage in Ayurveda, often credited with knowledge about children's health. His teachings, reflected in texts like Kashyapa-samhita, emphasize the importance of nurturing and protecting infants, aligning with the study's focus on enhancing immunological health in neonates.

36) Medicine:
Medicine here refers to the field combining various disciplines to promote health and cure diseases. The clinical study bridges traditional Ayurvedic practices with modern medical research, aiming to provide insights on effective treatments for enhancing immunity and reducing infant mortality rates.

37) Activity:
Activity in this context refers to the functional and therapeutic properties of the medicinal herbs encompassed in 'Bala compound'. It encompasses their actions on the immune system and overall health enhancement, highlighting the dynamic role traditional formulations play in modern health interventions.

38) Hridaya (Hrdaya):
Hridaya generally refers to the heart or core in Ayurvedic literature. In this context, it symbolizes the essential principles underlying health and wellness in individuals. It suggests an intrinsic connection between the holistic nature of Ayurveda and the studies conducted around enhancing health and immunity.

39) Dravya:
Dravya signifies material substances used in Ayurvedic formulations, primarily herbs, minerals, or animal products. It highlights the importance of understanding the properties of various dravyas in the composition of ‘Bala compound�, essential for the efficacy and safety of treatments aimed at infant health.

40) Ambika:
Ambika may refer to an Ayurvedic commentator or scholar, contributing to the depth of knowledge within the field. The acknowledgement of figures like Ambika indicates a connection between contemporary research and the historical scholarship that shapes Ayurvedic practice and its understanding of health.

41) Medhya:
Medhya refers to substances that are believed to enhance cognitive functions. In the context of 'Bala compound', Medhya indicates efforts not only to boost immunity but also to support intellectual development in infants, emphasizing the comprehensive approach of Ayurveda to health.

42) Dosha (Dosa):
Dosha represents the three fundamental energies in Ayurveda that govern physiological processes in the body. Addressing imbalances in dosha is crucial for maintaining health. In terms of the study, understanding doshas informs the Ayurvedic perspective on enhancing health and mitigating diseases in infants.

43) Gupta:
Gupta typically signifies a surname often associated with scholars in Ayurveda. Its appearance suggests collaboration between various knowledgeable practitioners and researchers, reflecting a collective effort in advancing Ayurvedic understanding and application in enhancing infant health and immunity.

44) Mishra (Misra):
Misra likely refers to a contributor or researcher in the field of Ayurveda whose work helps shape modern understanding of traditional medicine. Their involvement symbolizes the interplay between established Ayurvedic knowledge and contemporary health needs, particularly in infant care and immunology.

45) Balya:
Balya relates to something conducive to strength or vigor in Ayurveda, especially concerning children and infants. It emphasizes the significance of formulations that fortify young bodies, highlighting the overarching aim of 'Bala compound' to enhance resistance and promote overall health in infants.

46) Guru:
Guru refers to a teacher or mentor in the Ayurveda context, symbolizing the transmission of knowledge across generations. They play a critical role in educating practitioners about traditional approaches to health, emphasizing the value of mentorship in the continued development and application of Ayurveda.

47) Shri (Sri, Sr):
Shri is an honorific title often used in Indian culture to denote respect. Its use in the text highlights the reverence given to scholars and practitioners in Ayurveda, underlining the importance of respect for knowledge and tradition in facilitating health and wellness.

48) Guna:
Guna signifies qualities or attributes of substances in Ayurveda that determine their therapeutic effects. Understanding guna is essential for formulating effective remedies like 'Bala compound', ensuring that the intended benefits improve health and immunity in infants, resonating with Ayurvedic principles and practices.

Other Science Concepts:

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Discover the significance of concepts within the article: �Study on "Bala compound's" immunoglobulin effect in infants�. Further sources in the context of Science might help you critically compare this page with similair documents:

Dosha, Oja, Infant mortality rate, Clinical study, Trial Drug, Group A and group B, Ayurvedic text, Multicentric studies, Immunological status, Serum level, Healthy infant, Antibody production, Study subject.

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